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spisakt committed Nov 5, 2023
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title: Connectome-Based Attractor Dynamics Guide Brain Activity in Rest, Task, and Disease
title: Connectome-Based Attractor Dynamics Underly Brain Activity in Rest, Task, and Disease
subject: manuscript draft
#subtitle: Optional Subtitle
short_title: Manuscript
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**A** The distribution of time-frames on the fcHNN-projection separately for ASD patients and typically developing control (TDC) participants. <br></br>
**B** We quantified attractor state activations in the Autism Brain Imaging Data Exchange datasets ([study 7](tab-samples)) as the
individual-level mean activation of all time-frames belonging to the same attractor state. This analysis captured alterations similar to those previously associated to ASD-related perceptual atypicalities (visual, auditory and somatosensory cortices) as well as atypical integration of information about the “self” and the “other” (default mode network regions). All results are corrected for multiple comparisons across brain regions and attractor states (122*4 comparisons) with Bonferroni-correction. See {numref}`tab-clinical-results` and {numref}`Supplementary Figure %s <si_clinical_results_table>` for detailed results. <br></br>
**C** The comparison of data generated by fcHNNs initialized with ASD and TDC connectomes, respectively, revealed a characteristic pattern of differences in the system's dynamics, with increased pull towards (and potentially a higher separation between) the action and perception attractors attractors and a lower tendency of trajectories going towards the internal and external attractors. <br></br>
**C** The comparison of data generated by fcHNNs initialized with ASD and TDC connectomes, respectively, revealed a characteristic pattern of differences in the system's dynamics, with increased pull towards (and potentially a higher separation between) the action and perception attractors and a lower tendency of trajectories going towards the internal and external attractors. <br></br>
***Abbreviations**: MCC: middle cingulate cortex, ACC: anterior cingulate cortex, pg: perigenual, PFC: prefrontal cortex, dm: dorsomedial, dl: dorsolateral, STG: superior temporal gyrus, ITG: inferior temporal gyrus, Caud/Acc: caudate-accumbens, SM: sensorimotor, V1: primary visual, A1: primary auditory, SMA: supplementary motor cortex, ASD: autism spectrum disorder, TDC: typically developing control.*
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https://pni-lab.github.io/connattractor/

## Data availability
Study 1,2 and 4 is available at openneuro.org (ds002608, ds002608, ds000140). Data for study 3 is available upon request. Data for study 5-6 is available at the github page of the project: https://github.com/pni-lab/connattractor. Study 7 is available at https://fcon_1000.projects.nitrc.org/indi/abide/, preprocessed data is available at http://preprocessed-connectomes-project.org/.
Study 1, 2 and 4 is available at openneuro.org (ds002608, ds002608, ds000140). Data for study 3 is available upon request. Data for study 5-6 is available at the github page of the project: https://github.com/pni-lab/connattractor. Study 7 is available at https://fcon_1000.projects.nitrc.org/indi/abide/, preprocessed data is available at http://preprocessed-connectomes-project.org/.
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