diff --git a/src/prompt_toolkit/application/application.py b/src/prompt_toolkit/application/application.py
index 726fc0a06..c07ea4e94 100644
--- a/src/prompt_toolkit/application/application.py
+++ b/src/prompt_toolkit/application/application.py
@@ -960,7 +960,8 @@ def run_in_thread() -> None:
         def _called_from_ipython() -> bool:
             try:
                 return (
-                    "IPython/terminal/interactiveshell.py"
+                    sys.modules["IPython"].version_info < (8, 18, 0, "")
+                    and "IPython/terminal/interactiveshell.py"
                     in sys._getframe(3).f_code.co_filename
                 )
             except BaseException: