ts-cv.obo

[Term]
id: TS:0000001
name: Non conformity
def: "Monitored parameter out of range"
is_a: MS:1000547 ! Object attribute

[Term]
id: TS:0000002
name: Cause 
def: "Cause that generates a problem."
is_a: MS:1000547 ! Object attribute

[Term]
id: TS:0000003 
name: Decrease of MS1 signal
def: "The intensity of the signal in MS1 is lower than expected"
is_a: TS:0000024 ! Instrument Problem
part_of: TS00000065 MS1 problems

[Term]
id: TS:0000004
name: Sample carry over
def: "Part of the analyte present in a sample appears to be presest in the next or following samples."
is_a: TS:0000002 ! Cause
part_of: TS:0000003 ! Loss of MS1 signal
part_of: TS:0000011 The intensity of the signal in MS1 fluctuates
part_of: TS: 0000019 ! No signal in MS1
part_of: TS: 0000020 ! Bad chromatography

[Term]
id: TS:0000005
name: Air bubble in QC sample vial
def: "Air bubbles are present in the QC sample vial."
is_a: TS:0000002 ! Cause
part_of: TS:0000003 ! Loss of MS1 signal

[Term]
id: TS:0000006 
name: Bad QC sample
def: "QC sample is not correct."
is_a: TS:0000002 ! Cause
part_of: TS:0000003 ! Loss of MS1 signal

[Term]
id: TS:0000007
name: Empty solvents
def: "Bottles from LC solvents are empty."
is_a: TS:0000002 ! Cause
part_of: TS:0000003 ! Loss of MS1 signal 
part_of: TS: 0000019 ! No signal in MS1

[Term]
id: TS:0000008
name: Air in the chromatographic path
def: "Air bubbles in the chromatographic path."
is_a: TS:0000002 ! Cause
part_of: TS:0000003 ! Loss of MS1 signal
part_of: TS:0000020 ! Bad chromatography

[Term]
id: TS:0000009
name: Deteriorated column
def: "Chromatographic column is deteriorated."
is_a: TS:0000002 ! Cause
part_of: TS:0000003 ! Loss of MS1 signal 
part_of: TS: 0000014 ! Loss of MS1 signal in the central part of the chromatogram
part_of: TS:0000020 ! Bad chromatography

[Term]
id: TS:0000010
name: Column overpressure
def: "The column pressure is above the set limits"
is_a: TS:0000002 ! Cause
part_of: TS:0000003 ! Loss of MS1 signal

[Term]
id: TS:0000011 
name: MS1 signal fluctuation
def: "The intensity of the signal in MS1 is sometimes lower than expected and sometimes inside the thresholds of acceptance."
is_a: TS:0000024 ! Instrument Problem
part_of: TS00000065 MS1 problems

[Term]
id: TS:0000012
name: Dirty column emitter
def: "The emitter of the column is dirty"
is_a: TS:0000002 ! Cause
part_of: TS:0000011 The intensity of the signal in MS1 fluctuates
part_of: TS: 0000019 ! No signal in MS1

[Term]
id: TS:0000013
name: Dirty ion transfer tube
def: "The ion transfer tube is dirty"
is_a: TS:0000002 ! Cause
part_of: TS:0000011 The intensity of the signal in MS1 fluctuates
part_of: TS: 0000019 ! No signal in MS1

[Term]
id: TS:0000014
name: Loss of MS1 signal in the central part of the chromatogram
def: "The intensity of the signal in MS1 for complex samples is lower than expected only in the central part of the chromatogram"
is_a: TS:0000024 ! Instrument Problem
part_of: TS00000065 MS1 problems

[Term]
id: TS:0000015
name: Dirty ion path
def: "The ion path is dirty"
is_a: TS:0000002 ! Cause
part_of: TS:0000014 Loss of MS1 signal in the central part of the chromatogram

[Term]
id: TS:0000016
name: Sample injection step does not finish
def: "Sample injection process get stacked in the loading sample step"
is_a: TS:0000024 ! Instrument Problem
part_of: TS00000069 Chromatographic problems

[Term]
id: TS:0000017
name: Sample too concentrated
def: "The amount of injected sample is too high"
is_a: TS:0000002 ! Cause
part_of: TS:0000016 Sample injection step does not finish


[Term]
id: TS:0000018
name: Dirty sample
def: "Sample is contaminated with non peptidic compounds"
is_a: TS:0000002 ! Cause
part_of: TS:0000016 Sample injection step does not finish

[Term]
id: TS:0000019
name: No signal in MS1
def: "There is no signal in MS1"
is_a: TS:0000024 ! Instrument Problem
part_of: TS00000065 MS1 problems

[Term]
id: TS:0000020
name: Bad chromatography
def: "The shape, intensity or retention times of the chromatographic profile do not correspond with the expected"
is_a: TS:0000024 ! Instrument Problem
part_of: TS00000069 Chromatographic problems

[Term]
id: TS:0000021
name: Leak in the chromatographic system
def: "There is a leak of solvent in the chromatographic system"
is_a: TS:0000002 ! Cause
part_of: TS: 0000020 ! Bad chromatography

[Term]
id: TS:0000022
name: Uncalibrated masses
def: "The mass accuracy of the measured peptides is out of specifications"
is_a: TS:0000024 ! Instrument Problem
part_of: TS00000065 MS1 problems

[Term]
id: TS:0000023
name: Communication error
def: "The acquisition computer cannot connect with the instrument"
is_a: TS:0000024 ! Instrument Problem

[Term]
id: TS:0000024
name: Instrument Problem
def: "Instrument indicia that are associated with a performance out of the limits of acceptance."
is_a: MS:1000547 ! Object attribute

[Term]
id: TS:0000025
name: Action
def: "Action Taken to solve a problem"
is_a: MS:1000547 ! Object attribute

[Term]
id: TS:0000026
name: Test 
def: "Action taken to diagnose a problem"
is_a: MS:1000547 ! Object attribute 

[Term]
id: TS:0000027
name: Problem solved
def: "The problem has been solved and the instrument is ready to use"
is_a: TS:0000024 ! Instrument Problem

[Term]
id: TS:0000028
name: Column changed
def: "The chromatographic column has been changed"
is_a: TS:0000025 ! Action

[Term]
id: TS:0000029
name: Pre-column changed
def: "The chromatographic pre-column has been changed"
is_a: TS:0000025 ! Action

[Term]
id: TS:0000030
name: MS cleaned
def: "The mass spectrometer has been cleaned"
is_a: TS:0000025 ! Action

[Term]
id: TS:0000031
name: Ion transfer tube changed
def: "The ion transfer tube has been changed"
is_a: TS:0000025 ! Action
part_of: TS:0000035 MS mainteinance

[Term]
id: TS:0000032
name: Rotor seal changed
def: "The rotor seal has been changed"
is_a: TS:0000025 ! Action
part_of: TS:0000034 LC mainteinance

[Term]
id: TS:0000033
name: Piston seal changed
def: "The piston seal has been changed"
is_a: TS:0000025 ! Action
part_of: TS:0000034 LC mainteinance

[Term]
id: TS:0000034
name: LC maintenance
def: "Replacement or cleaning of parts of the LC has been done"
is_a: TS:0000025 ! Action

[Term]
id: TS:0000035
name: MS maintenance
def: "Replacement or cleaning of parts of the MS has been done"
is_a: TS:0000025 ! Action

[Term]
id: TS:0000036
name: LC cleaned
def: "The chromatographic path of the LC system has been cleaned"
is_a: TS:0000025 ! Action

[Term]
id: TS:0000037
name: QC aliquote changed
def: "The QC aliquote has been changed"
is_a: TS:0000025 ! Action

[Term]
id: TS:0000038
name: MS calibration
def: "The mass spectrometer has been calibrated"
is_a: TS:0000025 ! Action

[Term]
id: TS:0000039
name: Service Visit
def: "Service engineers have come to check the instrument"
is_a: TS:0000025 ! Action

[Term]
id: TS:0000040
name: Decrease of MS2 signal
def: "The intensity of the signal in MS2 is lower than expected"
is_a: TS:0000024 ! Instrument Problem

[Term]
id: TS:0000041
name: Overpressure in the chromatographic system
def: "The pressure of the chromatographic system exceeds the maximum set value"
is_a: TS:0000024 ! Instrument Problem
part_of: TS00000069 Chromatographic problems

[Term]
id: TS:0000042 
name: Spray issues
def: "The sample is not properly sprayed in the ion source"
is_a: TS:0000024 ! Instrument Problem
part_of: TS00000076 Source problems

[Term]
id: TS:0000043
name: Ion source cleaning
def: "The ion source has been cleaned"
is_a: TS:0000025 ! Action
part_of: TS:0000030 MS cleaned

[Term]
id: TS:0000044
name: MS full cleaning
def: "The full ion path of the instrument has been cleaned"
is_a: TS:0000025 ! Action
part_of: TS:0000030 MS cleaned

[Term]
id: TS:0000045
name: Sample loop changed
def: "The sample loop has been changed"
is_a: TS:0000025 ! Action
part_of: TS:0000034 LC mainteinance


[Term]
id: TS:0000046
name: Sample needle changed
def: "The autosampler needle has been changed"
is_a: TS:0000025 ! Action
part_of: TS:0000034 LC mainteinance

[Term]
id: TS:0000047
name: Column-out changed
def: "The capillar that goes from Valve S to the column assembly's inlet has been changed"
is_a: TS:0000025 ! Action
part_of: TS:0000034 LC mainteinance

[Term]
id: TS:0000048
name: Waste-in changed
def: "The capillar that goes from the column assembly's inlet to valve W has been changed"
is_a: TS:0000025 ! Action
part_of: TS:0000034 LC mainteinance

[Term]
id: TS:0000049
name: Chromatographic path cleaned
def: "The chromatographic path of the LC system has been cleaned"
is_a: TS:0000025 ! Action
part_of: TS:0000034 LC mainteinance

[Term]
id: TS:0000050
name: Column cleaned
def: "The chromatographic column has been cleaned"
is_a: TS:0000025 ! Action
part_of: TS:0000034 LC mainteinance 
part_of: TS:0000049 Chromatographic path cleaned

[Term]
id: TS:0000051
name: Loop cleaned 
def: "The injection loop has been cleaned"
is_a: TS:0000025 ! Action
part_of: TS:0000034 LC mainteinance
part_of: TS:0000049 Chromatographic path cleaned

[Term]
id: TS:0000052
name: Solvents mainteinance
def: "The chromatographic solvents have been replaced, refilled or emptied "
is_a: TS:0000025 ! Action
part_of: TS:0000034 LC mainteinance

[Term]
id: TS:0000053
name: Solvent S Filled
def: "Solvent S has been filled"
is_a: TS:0000025 ! Action
part_of: TS:0000034 LC mainteinance
part_of: TS:0000052 Solvents mainteinance

[Term]
id: TS:0000054
name: Solvent S Changed
def: "Solvent S has been changed"
is_a: TS:0000025 ! Action
part_of: TS:0000034 LC mainteinance
part_of: TS:0000052 Solvents mainteinance

[Term]
id: TS:0000055
name: Solvent A Filled
def: "Solvent A has been filled"
is_a: TS:0000025 ! Action
part_of: TS:0000034 LC mainteinance
part_of: TS:0000052 Solvents mainteinance

[Term]
id: TS:0000056
name: Solvent A Changed
def: "Solvent A has been changed"
is_a: TS:0000025 ! Action
part_of: TS:0000034 LC mainteinance
part_of: TS:0000052 Solvents mainteinance

[Term]
id: TS:0000057
name: Solvent B Filled
def: "Solvent B has been filled"
is_a: TS:0000025 ! Action
part_of: TS:0000034 LC mainteinance
part_of: TS:0000052 Solvents mainteinance

[Term]
id: TS:0000058
name: Solvent B Changed 
def: "Solvent B has been changed"
is_a: TS:0000025 ! Action
part_of: TS:0000034 LC mainteinance 
part_of: TS:0000052 Solvents mainteinance

[Term]
id: TS:0000059
name: Solvent W (empty)
def: "Solvent W has been emptied"
is_a: TS:0000025 ! Action
part_of: TS:0000034 LC mainteinance
part_of: TS:0000052 Solvents mainteinance

[Term]
id: TS:0000060
name: QC01 aliquote changed
def: "The vial with the QC 01 sample has been replaced with a new one"
is_a: TS:0000025 ! Action
part_of: TS:0000034 LC mainteinance
part_of: TS:0000037 QC aliquote changed

[Term]
id: TS:0000061
name: QC02 aliquote changed
def: "The vial with the QC02 sample has been replaced with a new one"
is_a: TS:0000025 ! Action
part_of: TS:0000034 LC mainteinance
part_of: TS:0000037 QC aliquote changed

[Term]
id: TS:0000062
name: QC03 aliquote changed
def: "The vial with the QC sample has been replaced with a new one"
is_a: TS:0000025 ! Action
part_of: TS:0000034 LC mainteinance 
part_of: TS:0000037 QC aliquote changed

[Term]
id: TS:0000063
name: Check mass 
def: "The accuracy of the mass measurements has been checked"
is_a: TS:0000025 ! Action
part_of: TS:0000035 MS mainteinance
part_of: TS:0000038 MS calibration

[Term]
id: TS:0000064
name: Full calibration
def: "The MS instrument has been fully calibrated"
is_a: TS:0000025 ! Action
part_of: TS:0000035 MS mainteinance 
part_of: TS:0000038 MS calibration

[Term]
id: TS:0000065
name: MS1 problems
def: "The signal in MS1 is different than expected"
is_a: TS:0000024 ! Instrument Problem

[Term]
id: TS:0000066
name: MS2 problems
def: "The signal in MS2 is different than expected"
is_a: TS:0000024 ! Instrument Problem

[Term]
id: TS:0000067
name: Chromatographic problems
def: "An issue is detected in the chromatography"
is_a: TS:0000024 ! Instrument Problem

[Term]
id: TS:0000068
name: Carry over 
def: "Contamination which causes sample peaks to re-appear in later runs"
is_a: TS:0000024 ! Instrument Problem
part_of: TS00000069 Chromatographic problems

[Term]
id: TS:0000069
name: Clogged paths 
def: "Part of the chromatographic part ic clogged"
is_a: TS:0000024 ! Instrument Problem
part_of: TS00000069 Chromatographic problems

[Term]
id: TS:0000070
name: Column clogged
def: "Chromatographic column is clogged"
is_a: TS:0000024 ! Instrument Problem
part_of: TS00000069 Chromatographic problems

[Term]
id: TS:0000071
name: Column-out clogged
def: "The column-out tube is clogged"
is_a: TS:0000024 ! Instrument Problem
part_of: TS00000069 Chromatographic problems

[Term]
id: TS:0000072
name: Waste-in clogged
def: "The waste-in tube is clogged"
is_a: TS:0000024 ! Instrument Problem
part_of: TS00000069 Chromatographic problems

[Term]
id: TS:0000073
name: Loop clogged
def: "The injection loop is clogged"
is_a: TS:0000024 ! Instrument Problem
part_of: TS00000069 Chromatographic problems

[Term]
id: TS:0000074
name: Source Problems
def: "The ion source is not working properly"
is_a: TS:0000024 ! Instrument Problem