diff --git a/src/EventLoop/Internal/AbstractDriver.php b/src/EventLoop/Internal/AbstractDriver.php
index fc2e732..8a2e2cc 100644
--- a/src/EventLoop/Internal/AbstractDriver.php
+++ b/src/EventLoop/Internal/AbstractDriver.php
@@ -48,6 +48,7 @@ abstract class AbstractDriver implements Driver
 
     private readonly \Closure $interruptCallback;
     private readonly \Closure $queueCallback;
+    /** @var \Closure(): (?\Closure(): mixed) */
     private readonly \Closure $runCallback;
 
     private readonly \stdClass $internalSuspensionMarker;
@@ -87,13 +88,16 @@ public function __construct()
         /** @psalm-suppress InvalidArgument */
         $this->interruptCallback = $this->setInterrupt(...);
         $this->queueCallback = $this->queue(...);
-        $this->runCallback = function () {
-            if ($this->fiber->isTerminated()) {
-                $this->createLoopFiber();
-            }
+        $this->runCallback =
+            /** @return ?\Closure(): mixed */
+            function (): ?\Closure {
+                if ($this->fiber->isTerminated()) {
+                    $this->createLoopFiber();
+                }
 
-            return $this->fiber->isStarted() ? $this->fiber->resume() : $this->fiber->start();
-        };
+                // Returns a callback that returns the value of the {main} fiber, or null in case of deadlock.
+                return $this->fiber->isStarted() ? $this->fiber->resume() : $this->fiber->start();
+            };
     }
 
     public function run(): void
@@ -533,26 +537,32 @@ private function createLoopFiber(): void
     {
         $this->fiber = new \Fiber(function (): void {
             $this->stopped = false;
+            do {
+                // Invoke microtasks if we have some
+                $this->invokeCallbacks();
 
-            // Invoke microtasks if we have some
-            $this->invokeCallbacks();
-
-            /** @psalm-suppress RedundantCondition $this->stopped may be changed by $this->invokeCallbacks(). */
-            while (!$this->stopped) {
-                if ($this->interrupt) {
-                    $this->invokeInterrupt();
-                }
+                /** @psalm-suppress RedundantCondition $this->stopped may be changed by $this->invokeCallbacks(). */
+                while (!$this->stopped) {
+                    if ($this->interrupt) {
+                        $this->invokeInterrupt();
+                    }
 
-                if ($this->isEmpty()) {
-                    return;
-                }
+                    if ($this->isEmpty()) {
+                        while (\gc_collect_cycles());
+                        if (!$this->microtaskQueue->isEmpty() || !$this->callbackQueue->isEmpty() || $this->interrupt) {
+                            continue 2;
+                        }
+                        return;
+                    }
 
-                $previousIdle = $this->idle;
-                $this->idle = true;
+                    $previousIdle = $this->idle;
+                    $this->idle = true;
 
-                $this->tick($previousIdle);
-                $this->invokeCallbacks();
-            }
+                    $this->tick($previousIdle);
+                    $this->invokeCallbacks();
+                }
+                return;
+            } while (true);
         });
     }
 
diff --git a/src/EventLoop/Internal/DriverSuspension.php b/src/EventLoop/Internal/DriverSuspension.php
index a3a7e29..6999638 100644
--- a/src/EventLoop/Internal/DriverSuspension.php
+++ b/src/EventLoop/Internal/DriverSuspension.php
@@ -28,6 +28,7 @@ final class DriverSuspension implements Suspension
     private bool $deadMain = false;
 
     /**
+     * @param \Closure(): (?\Closure(): mixed) $run
      * @param \WeakMap<object, \WeakReference<DriverSuspension>> $suspensions
      */
     public function __construct(
@@ -145,6 +146,7 @@ public function suspend(): mixed
             throw new \Error('Event loop terminated without resuming the current suspension (the cause is either a fiber deadlock, or an incorrectly unreferenced/canceled watcher):' . $info);
         }
 
+        assert($result !== null);
         return $result();
     }
 
diff --git a/test/EventLoopTest.php b/test/EventLoopTest.php
index 8f334f2..9aacf59 100644
--- a/test/EventLoopTest.php
+++ b/test/EventLoopTest.php
@@ -9,6 +9,130 @@
 
 class EventLoopTest extends TestCase
 {
+    public function testSuspensionResumptionWithQueueInGarbageCollection(): void
+    {
+        $suspension = EventLoop::getSuspension();
+
+        $class = new class ($suspension) {
+            public function __construct(public Suspension $suspension)
+            {
+            }
+            public function __destruct()
+            {
+                $this->suspension->resume(true);
+            }
+        };
+        $cycle = [$class, &$cycle];
+        unset($class, $cycle);
+
+        $ended = $suspension->suspend();
+
+        $this->assertTrue($ended);
+    }
+
+    public function testEventLoopResumptionWithQueueInGarbageCollection(): void
+    {
+        $suspension = EventLoop::getSuspension();
+
+        $class = new class ($suspension) {
+            public function __construct(public Suspension $suspension)
+            {
+            }
+            public function __destruct()
+            {
+                EventLoop::queue($this->suspension->resume(...), true);
+            }
+        };
+        $cycle = [$class, &$cycle];
+        unset($class, $cycle);
+
+        $ended = $suspension->suspend();
+
+        $this->assertTrue($ended);
+    }
+
+
+    public function testSuspensionResumptionWithQueueInGarbageCollectionNested(): void
+    {
+        $suspension = EventLoop::getSuspension();
+
+        $resumer = new class ($suspension) {
+            public function __construct(public Suspension $suspension)
+            {
+            }
+            public function __destruct()
+            {
+                $this->suspension->resume(true);
+            }
+        };
+
+        $class = new class ($resumer) {
+            public static ?object $staticReference = null;
+            public function __construct(object $resumer)
+            {
+                self::$staticReference = $resumer;
+            }
+            public function __destruct()
+            {
+                EventLoop::queue(function () {
+                    $class = self::$staticReference;
+                    $cycle = [$class, &$cycle];
+                    unset($class, $cycle);
+
+                    self::$staticReference = null;
+                });
+            }
+        };
+        $cycle = [$class, &$cycle];
+        unset($class, $resumer, $cycle);
+
+
+        $ended = $suspension->suspend();
+
+        $this->assertTrue($ended);
+    }
+
+    public function testEventLoopResumptionWithQueueInGarbageCollectionNested(): void
+    {
+        $suspension = EventLoop::getSuspension();
+
+        $resumer = new class ($suspension) {
+            public function __construct(public Suspension $suspension)
+            {
+            }
+            public function __destruct()
+            {
+                EventLoop::queue($this->suspension->resume(...), true);
+            }
+        };
+
+        $class = new class ($resumer) {
+            public static ?object $staticReference = null;
+            public function __construct(object $resumer)
+            {
+                self::$staticReference = $resumer;
+            }
+            public function __destruct()
+            {
+                EventLoop::queue(function () {
+                    $class = self::$staticReference;
+                    $cycle = [$class, &$cycle];
+                    unset($class, $cycle);
+
+                    self::$staticReference = null;
+                });
+            }
+        };
+        $cycle = [$class, &$cycle];
+        unset($class, $resumer, $cycle);
+
+
+        $ended = $suspension->suspend();
+
+        $this->assertTrue($ended);
+    }
+
+
     public function testDelayWithNegativeDelay(): void
     {
         $this->expectException(\Error::class);