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DOI

Ryan E. Harvey, Heath L. Robinson, Can Liu, Azahara Oliva, & Antonio Fernandez-Ruiz

Traditionally considered a homogeneous cell type, hippocampal pyramidal cells have been recently shown to be highly diverse. However, how this cellular diversity relates to the different hippocampal network computations that support memory-guided behavior is not yet known. We discovered that the anatomical identity of pyramidal cells is a major organizing principle of CA1 assembly dynamics, the emergence of memory replay, and cortical projection patterns. Segregated pyramidal cell subpopulations encoded trajectory and choice-specific information or tracked changes in reward configuration respectively, and selectively routed these representations to different cortical targets. Furthermore, distinct hippocampo-cortical assemblies coordinated the reactivation of complementary memory representations. These findings reveal the existence of specialized hippocampo-cortical subcircuits and provide a cellular mechanism that supports the computational flexibility and memory capacities of these structures.

Installation

    $ git clone https://github.com/ryanharvey1/ripple_heterogeneity.git
    $ cd ripple_heterogeneity
    $ conda env create --name ripple_heterogeneity --file=environment.yml
    $ pip install -e .