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Kh2.mod
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Kh2.mod
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COMMENT
**************************************************
File generated by: neuroConstruct v1.6.0
**************************************************
This file holds the implementation in NEURON of the Cell Mechanism:
Kh2 (Type: Channel mechanism, Model: Template based ChannelML file)
with parameters:
/channelml/@units = Physiological Units
/channelml/notes = ChannelML file containing a single Channel from De Schutter and Bower 1998
/channelml/ion/@name = k
/channelml/ion/@charge = 1
/channelml/ion/@default_erev = -85
/channelml/channel_type/@name = Kh2
/channelml/channel_type/@density = yes
/channelml/channel_type/status/@value = stable
/channelml/channel_type/status/comment = Verified equivalence of NEURON and GENESIS mapping to orig NEURON mod impl at 0.02ms dt with current pulse
/channelml/channel_type/status/issue = Orig NEURON impl had to be 'fixed' to include READ ek for ion, otherwise was using the internally set value of -30!
/channelml/channel_type/status/contributor/name = Padraig Gleeson
/channelml/channel_type/notes = Anomalous rectifier current. Based on Roth et al's reimplementation of original GENESIS model in NEURON
/channelml/channel_type/authorList/modelAuthor[1]/name = De Schutter, E.
/channelml/channel_type/authorList/modelAuthor[2]/name = Bower, J.
/channelml/channel_type/authorList/modelTranslator[1]/name = Padraig Gleeson
/channelml/channel_type/authorList/modelTranslator[1]/institution = UCL
/channelml/channel_type/authorList/modelTranslator[1]/email = p.gleeson - at - ucl.ac.uk
/channelml/channel_type/authorList/modelTranslator[2]/name = Jenny Davie
/channelml/channel_type/authorList/modelTranslator[2]/institution = UCL
/channelml/channel_type/authorList/modelTranslator[2]/comment = Conversion of GENESIS model to NEURON
/channelml/channel_type/authorList/modelTranslator[3]/name = Arnd Roth
/channelml/channel_type/authorList/modelTranslator[3]/institution = UCL
/channelml/channel_type/authorList/modelTranslator[3]/comment = Conversion of GENESIS model to NEURON
/channelml/channel_type/authorList/modelTranslator[4]/name = Volker Steuber
/channelml/channel_type/authorList/modelTranslator[4]/institution = UCL
/channelml/channel_type/authorList/modelTranslator[4]/comment = Conversion of GENESIS model to NEURON
/channelml/channel_type/authorList/modelTranslator[5]/name = Michael Hausser
/channelml/channel_type/authorList/modelTranslator[5]/institution = UCL
/channelml/channel_type/authorList/modelTranslator[5]/comment = Conversion of GENESIS model to NEURON
/channelml/channel_type/publication/fullTitle = De Schutter, E., and Bower, J. M. (1994). An active membrane model of the cerebellar Purkinje cell. I. Simulation of current clamps in slice. J Neurop ...
/channelml/channel_type/publication/pubmedRef = http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=7512629
/channelml/channel_type/neuronDBref/modelName = K channels
/channelml/channel_type/neuronDBref/uri = http://senselab.med.yale.edu/senselab/NeuronDB/channelGene2.htm#table3
/channelml/channel_type/current_voltage_relation/ohmic/@ion = k
/channelml/channel_type/current_voltage_relation/ohmic/conductance/@default_gmax = 0.3
/channelml/channel_type/current_voltage_relation/ohmic/conductance/rate_adjustments/q10_settings/@q10_factor = 3
/channelml/channel_type/current_voltage_relation/ohmic/conductance/rate_adjustments/q10_settings/@experimental_temp = 37
/channelml/channel_type/current_voltage_relation/ohmic/conductance/gate/@power = 1
/channelml/channel_type/current_voltage_relation/ohmic/conductance/gate/state/@name = m
/channelml/channel_type/current_voltage_relation/ohmic/conductance/gate/state/@fraction = 1
/channelml/channel_type/hh_gate/@state = m
/channelml/channel_type/hh_gate/transition/voltage_gate/tau/generic_equation_hh/@expr = 36.8
/channelml/channel_type/hh_gate/transition/voltage_gate/inf/parameterised_hh/@type = sigmoid
/channelml/channel_type/hh_gate/transition/voltage_gate/inf/parameterised_hh/@expr = A/(1 + exp(k*(v-d)))
/channelml/channel_type/hh_gate/transition/voltage_gate/inf/parameterised_hh/parameter[1]/@name = A
/channelml/channel_type/hh_gate/transition/voltage_gate/inf/parameterised_hh/parameter[1]/@value = 0.2
/channelml/channel_type/hh_gate/transition/voltage_gate/inf/parameterised_hh/parameter[2]/@name = k
/channelml/channel_type/hh_gate/transition/voltage_gate/inf/parameterised_hh/parameter[2]/@value = 0.142857142
/channelml/channel_type/hh_gate/transition/voltage_gate/inf/parameterised_hh/parameter[3]/@name = d
/channelml/channel_type/hh_gate/transition/voltage_gate/inf/parameterised_hh/parameter[3]/@value = -82
/channelml/channel_type/impl_prefs/comment = Note, Using the NEURON mod file impl settings to get a closer match
/channelml/channel_type/impl_prefs/table_settings/@max_v = 100
/channelml/channel_type/impl_prefs/table_settings/@min_v = -100
/channelml/channel_type/impl_prefs/table_settings/@table_divisions = 200
// File from which this was generated: /Users/hashmup/nC_projects/PurkinjeCell.ncx/cellMechanisms/Kh2/Kh2_Chan.xml
// XSL file with mapping to simulator: /Users/hashmup/nC_projects/PurkinjeCell.ncx/cellMechanisms/Kh2/ChannelML_v1.8.1_NEURONmod.xsl
ENDCOMMENT
? This is a NEURON mod file generated from a ChannelML file
? Unit system of original ChannelML file: Physiological Units
COMMENT
ChannelML file containing a single Channel from De Schutter and Bower 1998
ENDCOMMENT
TITLE Channel: Kh2
COMMENT
Anomalous rectifier current. Based on Roth et al's reimplementation of original GENESIS model in NEURON
ENDCOMMENT
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
(S) = (siemens)
(um) = (micrometer)
(molar) = (1/liter)
(mM) = (millimolar)
(l) = (liter)
}
NEURON {
SUFFIX Kh2
USEION k READ ek WRITE ik VALENCE 1 ? reversal potential of ion is read, outgoing current is written
RANGE gmax, gion
RANGE minf, mtau
}
PARAMETER {
gmax = 0.0003 (S/cm2) ? default value, should be overwritten when conductance placed on cell
}
ASSIGNED {
v (mV)
celsius (degC)
? Reversal potential of k
ek (mV)
? The outward flow of ion: k calculated by rate equations...
ik (mA/cm2)
gion (S/cm2)
minf
mtau (ms)
}
BREAKPOINT {
SOLVE states METHOD cnexp
gion = gmax*((1*m)^1)
ik = gion*(v - ek)
}
INITIAL {
ek = -85
rates(v)
m = minf
}
STATE {
m
}
DERIVATIVE states {
rates(v)
m' = (minf - m)/mtau
}
PROCEDURE rates(v(mV)) {
? Note: not all of these may be used, depending on the form of rate equations
LOCAL alpha, beta, tau, inf, gamma, zeta, temp_adj_m, A_tau_m, k_tau_m, d_tau_m, A_inf_m, k_inf_m, d_inf_m
TABLE minf, mtau
DEPEND celsius
FROM -100 TO 100 WITH 200
UNITSOFF
? There is a Q10 factor which will alter the tau of the gates
temp_adj_m = 3^((celsius - 37)/10)
? *** Adding rate equations for gate: m ***
? Found a generic form of the rate equation for tau, using expression: 36.8
tau = 36.8
mtau = tau/temp_adj_m
? Found a parameterised form of rate equation for inf, using expression: A / (1 + exp(k*(v-d)))
A_inf_m = 0.2
k_inf_m = 0.142857142
d_inf_m = -82
inf = A_inf_m / (exp((v - d_inf_m) * k_inf_m) + 1)
minf = inf
? *** Finished rate equations for gate: m ***
}
UNITSON