Kh2_nmodl.mod

COMMENT

   **************************************************
   File generated by: neuroConstruct v1.6.0 
   **************************************************

   This file holds the implementation in NEURON of the Cell Mechanism:
   Kh2_nmodl (Type: Channel mechanism, Model: File Based Membrane Mechanism)

   with parameters: 
   Max Conductance Density = 3.0E-9 mS um^-2 

ENDCOMMENT

TITLE Anomalous rectifier
 
COMMENT
  from "An Active Membrane Model of the Cerebellar Purkinje Cell
        1. Simulation of Current Clamp in Slice"
  
  "Anomalous Rectification in Neurons from Cat Sensorimotor Cortex
    In Vitro" W.J.SPAIN, P.C.SCHWINDT, and W.E.CRILL
           JOURNAL OF NEUROPHYSIOLOGY Vol 57, No.5

Taken from De Schutter model conversion from GENESIS by Jenny Davie, Arnd Roth,
   Volker Steuber, Erik De Schutter & Michael Hausser 28.8.2004

ENDCOMMENT
 
UNITS {
        (mA) = (milliamp)
        (mV) = (millivolt)
}
 
NEURON {
        SUFFIX Kh2_nmodl
        USEION k READ ek WRITE ik        :////PG///  Note!!! originally no 'READ ek' here, so it used -30 (below), ignoring external ek
        RANGE  gmax, gk, minf, nexp, ik
} 
 
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
 
PARAMETER {
        v (mV)
        celsius = 37 (degC)
        dt (ms)
        gmax   = 3.0E-4 (mho/cm2)
        ek      = -30 (mV)

}
 
STATE {
        m 
}
 
ASSIGNED {
        ik (mA/cm2)
        gk minf nexp
}
 
BREAKPOINT {
        SOLVE states
        gk = gmax *m
        ik = gk* (v-ek)
}
 
UNITSOFF
 
INITIAL {
        rates(v)
        m = minf
}

PROCEDURE states() {  :Computes state variables m, 
        rates(v)      :             at the current v and dt.
        m = m + nexp*(minf-m)
}

PROCEDURE rates(v) {  :Computes rate and other constants at current v.
                      :Call once from HOC to initialize inf at resting v.
        LOCAL  q10, tinc
        TABLE minf,nexp DEPEND dt, celsius FROM -100 TO 100 WITH 200
        q10 = 3^((celsius - 37)/10)
        tinc = -dt * q10
                :"m" potassium activation system
        minf = 0.2/(1+exp((v+82)/7))
        nexp = 1 - exp(tinc/36.8)
}

 
UNITSON