setup.py

from distutils.core import setup
from distutils.extension import Extension
from Cython.Distutils import build_ext
from Cython.Build import cythonize
import numpy
import sys
import os
import glob

lib_folder = os.path.join(sys.prefix, 'lib')

# Find opencv libraries in lib_folder
cvlibs = list()
for file in glob.glob(os.path.join(lib_folder, 'libopencv_*')):
    cvlibs.append(file.split('.')[0])
cvlibs = list(set(cvlibs))
cvlibs = ['-L{}'.format(lib_folder)] + \
         ['opencv_{}'.format(lib.split(os.path.sep)[-1].split('libopencv_')[-1]) for lib in cvlibs]

setup(
    cmdclass={'build_ext': build_ext},
    ext_modules=cythonize(Extension("opencv_mat",
                                    sources=["opencv_mat.pyx"],
                                    language="c++",
                                    include_dirs=[numpy.get_include(),
                                                  os.path.join(sys.prefix, 'include', 'opencv2'),
                                                 ],
                                    library_dirs=[lib_folder],
                                    libraries=cvlibs,
                                    )
                          )
)