11_multiplex_enrichment.ipynb

{
 "cells": [
  {
   "cell_type": "code",
   "execution_count": 1,
   "metadata": {},
   "outputs": [],
   "source": [
    "import gseapy as gp\n",
    "import pandas as pd"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "# Information on Multiplex Analysis \n",
    "\n",
    "In this notebook you will find code to check the enrichment of each group of genes identified in the multiplex analysis part.\n",
    "\n",
    "##  Main function\n",
    "\n",
    "This function will be run for each group:"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 2,
   "metadata": {},
   "outputs": [],
   "source": [
    "def print_lists_to_enrich(lists_to_enrich):\n",
    "    # Making the column width big enough so it's possible to see the enriched terms.\n",
    "    pd.set_option('display.max_colwidth', None)\n",
    "    pd.set_option('display.width', 5000)\n",
    "\n",
    "    for ind, list_enr in enumerate(lists_to_enrich):\n",
    "        enr = gp.enrichr(gene_list=list_enr,\n",
    "                                 organism='human',\n",
    "                                 description=\"multiplex_all_tissues_\" + str(ind),\n",
    "                                 gene_sets='Reactome_2016',\n",
    "                                 cutoff=0.05,\n",
    "                                 no_plot=True, # skip plotting, because we don't need these figures\n",
    "                                 outdir='results/EnrichClass')\n",
    "        filtered_df = enr.results[enr.results['Adjusted P-value'] < 0.05].loc[:, ['Adjusted P-value', 'Term']]\n",
    "        \n",
    "        print(f'{\" - \".join(list_enr)}:')\n",
    "        if filtered_df.shape[0] == 0:\n",
    "            print('No enrichment below adjusted p-value $< 0.05$.')\n",
    "        else:\n",
    "            display(filtered_df)\n",
    "        print('\\n')\n",
    "    pd.reset_option('display.width')\n",
    "    pd.reset_option('display.max_colwidth')"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### All tissues"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 4,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "PRM1 - PRM2:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "PWP2 - C21orf33:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "HBA1 - HBA2:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n"
     ]
    }
   ],
   "source": [
    "all_tissues_to_enrich= [\n",
    "    ['PRM1', 'PRM2'],\n",
    "    ['PWP2', 'C21orf33'],\n",
    "    ['HBA1', 'HBA2']\n",
    "]\n",
    "\n",
    "print_lists_to_enrich(all_tissues_to_enrich)"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Brain tissues"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 10,
   "metadata": {
    "scrolled": true
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "GP2 - PNLIPRP1 - CTRB1 - PLA2G1B - CPB1 - SPINK1 - PNLIP - CTRC - CTRB2 - CLPS - CELA3A - CELA2A - CPA1 - REG1B - PRSS1 - REG1A - SYCN - CELA3B:\n"
     ]
    },
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       "      <th></th>\n",
       "      <th>Adjusted P-value</th>\n",
       "      <th>Term</th>\n",
       "    </tr>\n",
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       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0.000004</td>\n",
       "      <td>Metabolism of vitamins and cofactors Homo sapiens R-HSA-196854</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>0.000002</td>\n",
       "      <td>Cobalamin (Cbl, vitamin B12) transport and metabolism Homo sapiens R-HSA-196741</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>0.000211</td>\n",
       "      <td>Digestion of dietary lipid Homo sapiens R-HSA-192456</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>0.000602</td>\n",
       "      <td>Metabolism of water-soluble vitamins and cofactors Homo sapiens R-HSA-196849</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>0.000914</td>\n",
       "      <td>Activation of Matrix Metalloproteinases Homo sapiens R-HSA-1592389</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>5</th>\n",
       "      <td>0.008586</td>\n",
       "      <td>Lipid digestion, mobilization, and transport Homo sapiens R-HSA-73923</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>0.024355</td>\n",
       "      <td>Degradation of the extracellular matrix Homo sapiens R-HSA-1474228</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7</th>\n",
       "      <td>0.023552</td>\n",
       "      <td>Metabolism Homo sapiens R-HSA-1430728</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
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      ],
      "text/plain": [
       "   Adjusted P-value                                                                             Term\n",
       "0          0.000004                   Metabolism of vitamins and cofactors Homo sapiens R-HSA-196854\n",
       "1          0.000002  Cobalamin (Cbl, vitamin B12) transport and metabolism Homo sapiens R-HSA-196741\n",
       "2          0.000211                             Digestion of dietary lipid Homo sapiens R-HSA-192456\n",
       "3          0.000602     Metabolism of water-soluble vitamins and cofactors Homo sapiens R-HSA-196849\n",
       "4          0.000914               Activation of Matrix Metalloproteinases Homo sapiens R-HSA-1592389\n",
       "5          0.008586            Lipid digestion, mobilization, and transport Homo sapiens R-HSA-73923\n",
       "6          0.024355               Degradation of the extracellular matrix Homo sapiens R-HSA-1474228\n",
       "7          0.023552                                            Metabolism Homo sapiens R-HSA-1430728"
      ]
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     "text": [
      "\n",
      "\n",
      "HBA2 - ALAS2 - HBD - HBB - HBA1:\n"
     ]
    },
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       "      <th>Adjusted P-value</th>\n",
       "      <th>Term</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0.002141</td>\n",
       "      <td>Erythrocytes take up oxygen and release carbon dioxide Homo sapiens R-HSA-1247673</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>0.002522</td>\n",
       "      <td>Erythrocytes take up carbon dioxide and release oxygen Homo sapiens R-HSA-1237044</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>0.001681</td>\n",
       "      <td>O2/CO2 exchange in erythrocytes Homo sapiens R-HSA-1480926</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>0.019707</td>\n",
       "      <td>Scavenging of heme from plasma Homo sapiens R-HSA-2168880</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>0.041029</td>\n",
       "      <td>Binding and Uptake of Ligands by Scavenger Receptors Homo sapiens R-HSA-2173782</td>\n",
       "    </tr>\n",
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      ],
      "text/plain": [
       "   Adjusted P-value                                                                               Term\n",
       "0          0.002141  Erythrocytes take up oxygen and release carbon dioxide Homo sapiens R-HSA-1247673\n",
       "1          0.002522  Erythrocytes take up carbon dioxide and release oxygen Homo sapiens R-HSA-1237044\n",
       "2          0.001681                         O2/CO2 exchange in erythrocytes Homo sapiens R-HSA-1480926\n",
       "3          0.019707                          Scavenging of heme from plasma Homo sapiens R-HSA-2168880\n",
       "4          0.041029    Binding and Uptake of Ligands by Scavenger Receptors Homo sapiens R-HSA-2173782"
      ]
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     "output_type": "stream",
     "text": [
      "\n",
      "\n",
      "CD74 - HLA.DRA:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "KDM5C - ZFX - DDX3X:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "RPS15A - RPL35A - RPS27:\n"
     ]
    },
    {
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       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>Adjusted P-value</th>\n",
       "      <th>Term</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0.000109</td>\n",
       "      <td>Viral mRNA Translation Homo sapiens R-HSA-192823</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>0.000055</td>\n",
       "      <td>Peptide chain elongation Homo sapiens R-HSA-156902</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>0.000041</td>\n",
       "      <td>Selenocysteine synthesis Homo sapiens R-HSA-2408557</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>0.000030</td>\n",
       "      <td>Eukaryotic Translation Termination Homo sapiens R-HSA-72764</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>0.000026</td>\n",
       "      <td>Eukaryotic Translation Elongation Homo sapiens R-HSA-156842</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>5</th>\n",
       "      <td>0.000022</td>\n",
       "      <td>Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Homo sapiens R-HSA-975956</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>0.000023</td>\n",
       "      <td>Formation of a pool of free 40S subunits Homo sapiens R-HSA-72689</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7</th>\n",
       "      <td>0.000028</td>\n",
       "      <td>Nonsense-Mediated Decay (NMD) Homo sapiens R-HSA-927802</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8</th>\n",
       "      <td>0.000025</td>\n",
       "      <td>Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Homo sapiens R-HSA-975957</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>9</th>\n",
       "      <td>0.000022</td>\n",
       "      <td>L13a-mediated translational silencing of Ceruloplasmin expression Homo sapiens R-HSA-156827</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>10</th>\n",
       "      <td>0.000020</td>\n",
       "      <td>3' -UTR-mediated translational regulation Homo sapiens R-HSA-157279</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>11</th>\n",
       "      <td>0.000019</td>\n",
       "      <td>SRP-dependent cotranslational protein targeting to membrane Homo sapiens R-HSA-1799339</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>12</th>\n",
       "      <td>0.000018</td>\n",
       "      <td>GTP hydrolysis and joining of the 60S ribosomal subunit Homo sapiens R-HSA-72706</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13</th>\n",
       "      <td>0.000018</td>\n",
       "      <td>Selenoamino acid metabolism Homo sapiens R-HSA-2408522</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>14</th>\n",
       "      <td>0.000018</td>\n",
       "      <td>Cap-dependent Translation Initiation Homo sapiens R-HSA-72737</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>15</th>\n",
       "      <td>0.000017</td>\n",
       "      <td>Eukaryotic Translation Initiation Homo sapiens R-HSA-72613</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>16</th>\n",
       "      <td>0.000023</td>\n",
       "      <td>Influenza Viral RNA Transcription and Replication Homo sapiens R-HSA-168273</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>17</th>\n",
       "      <td>0.000026</td>\n",
       "      <td>Influenza Life Cycle Homo sapiens R-HSA-168255</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>18</th>\n",
       "      <td>0.000031</td>\n",
       "      <td>Influenza Infection Homo sapiens R-HSA-168254</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>19</th>\n",
       "      <td>0.000032</td>\n",
       "      <td>Translation Homo sapiens R-HSA-72766</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>20</th>\n",
       "      <td>0.000041</td>\n",
       "      <td>Major pathway of rRNA processing in the nucleolus Homo sapiens R-HSA-6791226</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>21</th>\n",
       "      <td>0.000050</td>\n",
       "      <td>rRNA processing Homo sapiens R-HSA-72312</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>22</th>\n",
       "      <td>0.000310</td>\n",
       "      <td>Metabolism of amino acids and derivatives Homo sapiens R-HSA-71291</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>23</th>\n",
       "      <td>0.000333</td>\n",
       "      <td>Infectious disease Homo sapiens R-HSA-5663205</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>24</th>\n",
       "      <td>0.001123</td>\n",
       "      <td>Formation of the ternary complex, and subsequently, the 43S complex Homo sapiens R-HSA-72695</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>25</th>\n",
       "      <td>0.001406</td>\n",
       "      <td>Ribosomal scanning and start codon recognition Homo sapiens R-HSA-72702</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>26</th>\n",
       "      <td>0.001354</td>\n",
       "      <td>Translation initiation complex formation Homo sapiens R-HSA-72649</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>27</th>\n",
       "      <td>0.001352</td>\n",
       "      <td>Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Homo sapiens R-HSA-72662</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>28</th>\n",
       "      <td>0.002503</td>\n",
       "      <td>Disease Homo sapiens R-HSA-1643685</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>29</th>\n",
       "      <td>0.007876</td>\n",
       "      <td>Metabolism of proteins Homo sapiens R-HSA-392499</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>30</th>\n",
       "      <td>0.026721</td>\n",
       "      <td>Gene Expression Homo sapiens R-HSA-74160</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>31</th>\n",
       "      <td>0.041453</td>\n",
       "      <td>Metabolism Homo sapiens R-HSA-1430728</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
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      ],
      "text/plain": [
       "    Adjusted P-value                                                                                                                             Term\n",
       "0           0.000109                                                                                 Viral mRNA Translation Homo sapiens R-HSA-192823\n",
       "1           0.000055                                                                               Peptide chain elongation Homo sapiens R-HSA-156902\n",
       "2           0.000041                                                                              Selenocysteine synthesis Homo sapiens R-HSA-2408557\n",
       "3           0.000030                                                                      Eukaryotic Translation Termination Homo sapiens R-HSA-72764\n",
       "4           0.000026                                                                      Eukaryotic Translation Elongation Homo sapiens R-HSA-156842\n",
       "5           0.000022                           Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Homo sapiens R-HSA-975956\n",
       "6           0.000023                                                                Formation of a pool of free 40S subunits Homo sapiens R-HSA-72689\n",
       "7           0.000028                                                                          Nonsense-Mediated Decay (NMD) Homo sapiens R-HSA-927802\n",
       "8           0.000025                              Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Homo sapiens R-HSA-975957\n",
       "9           0.000022                                      L13a-mediated translational silencing of Ceruloplasmin expression Homo sapiens R-HSA-156827\n",
       "10          0.000020                                                              3' -UTR-mediated translational regulation Homo sapiens R-HSA-157279\n",
       "11          0.000019                                           SRP-dependent cotranslational protein targeting to membrane Homo sapiens R-HSA-1799339\n",
       "12          0.000018                                                 GTP hydrolysis and joining of the 60S ribosomal subunit Homo sapiens R-HSA-72706\n",
       "13          0.000018                                                                           Selenoamino acid metabolism Homo sapiens R-HSA-2408522\n",
       "14          0.000018                                                                    Cap-dependent Translation Initiation Homo sapiens R-HSA-72737\n",
       "15          0.000017                                                                       Eukaryotic Translation Initiation Homo sapiens R-HSA-72613\n",
       "16          0.000023                                                      Influenza Viral RNA Transcription and Replication Homo sapiens R-HSA-168273\n",
       "17          0.000026                                                                                   Influenza Life Cycle Homo sapiens R-HSA-168255\n",
       "18          0.000031                                                                                    Influenza Infection Homo sapiens R-HSA-168254\n",
       "19          0.000032                                                                                             Translation Homo sapiens R-HSA-72766\n",
       "20          0.000041                                                     Major pathway of rRNA processing in the nucleolus Homo sapiens R-HSA-6791226\n",
       "21          0.000050                                                                                         rRNA processing Homo sapiens R-HSA-72312\n",
       "22          0.000310                                                               Metabolism of amino acids and derivatives Homo sapiens R-HSA-71291\n",
       "23          0.000333                                                                                    Infectious disease Homo sapiens R-HSA-5663205\n",
       "24          0.001123                                     Formation of the ternary complex, and subsequently, the 43S complex Homo sapiens R-HSA-72695\n",
       "25          0.001406                                                          Ribosomal scanning and start codon recognition Homo sapiens R-HSA-72702\n",
       "26          0.001354                                                                Translation initiation complex formation Homo sapiens R-HSA-72649\n",
       "27          0.001352  Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Homo sapiens R-HSA-72662\n",
       "28          0.002503                                                                                               Disease Homo sapiens R-HSA-1643685\n",
       "29          0.007876                                                                                 Metabolism of proteins Homo sapiens R-HSA-392499\n",
       "30          0.026721                                                                                         Gene Expression Homo sapiens R-HSA-74160\n",
       "31          0.041453                                                                                            Metabolism Homo sapiens R-HSA-1430728"
      ]
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     "output_type": "stream",
     "text": [
      "\n",
      "\n",
      "RPS12 - RPL32 - RPL26 - RPL23 - RPL11 - RPL37A - RPL31 - RPL30 - RPL36A - RPL21 - RPL13A - RPS21 - RPS3A - RPS16 - RPS29 - RPL27A - RPL38:\n"
     ]
    },
    {
     "data": {
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       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>Adjusted P-value</th>\n",
       "      <th>Term</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>1.063434e-38</td>\n",
       "      <td>Viral mRNA Translation Homo sapiens R-HSA-192823</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>5.317171e-39</td>\n",
       "      <td>Peptide chain elongation Homo sapiens R-HSA-156902</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>6.864293e-39</td>\n",
       "      <td>Selenocysteine synthesis Homo sapiens R-HSA-2408557</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>5.148220e-39</td>\n",
       "      <td>Eukaryotic Translation Termination Homo sapiens R-HSA-72764</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>6.310234e-39</td>\n",
       "      <td>Eukaryotic Translation Elongation Homo sapiens R-HSA-156842</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>5</th>\n",
       "      <td>5.258529e-39</td>\n",
       "      <td>Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Homo sapiens R-HSA-975956</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>1.853563e-38</td>\n",
       "      <td>Formation of a pool of free 40S subunits Homo sapiens R-HSA-72689</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7</th>\n",
       "      <td>1.016131e-37</td>\n",
       "      <td>Nonsense-Mediated Decay (NMD) Homo sapiens R-HSA-927802</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8</th>\n",
       "      <td>9.032274e-38</td>\n",
       "      <td>Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Homo sapiens R-HSA-975957</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>9</th>\n",
       "      <td>8.129047e-38</td>\n",
       "      <td>L13a-mediated translational silencing of Ceruloplasmin expression Homo sapiens R-HSA-156827</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>10</th>\n",
       "      <td>7.390042e-38</td>\n",
       "      <td>3' -UTR-mediated translational regulation Homo sapiens R-HSA-157279</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>11</th>\n",
       "      <td>8.053898e-38</td>\n",
       "      <td>SRP-dependent cotranslational protein targeting to membrane Homo sapiens R-HSA-1799339</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>12</th>\n",
       "      <td>7.434367e-38</td>\n",
       "      <td>GTP hydrolysis and joining of the 60S ribosomal subunit Homo sapiens R-HSA-72706</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13</th>\n",
       "      <td>1.355846e-37</td>\n",
       "      <td>Selenoamino acid metabolism Homo sapiens R-HSA-2408522</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>14</th>\n",
       "      <td>2.063954e-37</td>\n",
       "      <td>Cap-dependent Translation Initiation Homo sapiens R-HSA-72737</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>15</th>\n",
       "      <td>1.934957e-37</td>\n",
       "      <td>Eukaryotic Translation Initiation Homo sapiens R-HSA-72613</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>16</th>\n",
       "      <td>1.506743e-36</td>\n",
       "      <td>Influenza Viral RNA Transcription and Replication Homo sapiens R-HSA-168273</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>17</th>\n",
       "      <td>4.270615e-36</td>\n",
       "      <td>Influenza Life Cycle Homo sapiens R-HSA-168255</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>18</th>\n",
       "      <td>1.646512e-35</td>\n",
       "      <td>Influenza Infection Homo sapiens R-HSA-168254</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>19</th>\n",
       "      <td>2.535245e-35</td>\n",
       "      <td>Translation Homo sapiens R-HSA-72766</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>20</th>\n",
       "      <td>1.318658e-34</td>\n",
       "      <td>Major pathway of rRNA processing in the nucleolus Homo sapiens R-HSA-6791226</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>21</th>\n",
       "      <td>5.337596e-34</td>\n",
       "      <td>rRNA processing Homo sapiens R-HSA-72312</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>22</th>\n",
       "      <td>2.843663e-29</td>\n",
       "      <td>Metabolism of amino acids and derivatives Homo sapiens R-HSA-71291</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>23</th>\n",
       "      <td>5.288175e-29</td>\n",
       "      <td>Infectious disease Homo sapiens R-HSA-5663205</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>24</th>\n",
       "      <td>1.641292e-23</td>\n",
       "      <td>Disease Homo sapiens R-HSA-1643685</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>25</th>\n",
       "      <td>1.337958e-20</td>\n",
       "      <td>Metabolism of proteins Homo sapiens R-HSA-392499</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>26</th>\n",
       "      <td>1.635971e-17</td>\n",
       "      <td>Gene Expression Homo sapiens R-HSA-74160</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>27</th>\n",
       "      <td>2.298437e-16</td>\n",
       "      <td>Metabolism Homo sapiens R-HSA-1430728</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>28</th>\n",
       "      <td>2.536855e-08</td>\n",
       "      <td>Formation of the ternary complex, and subsequently, the 43S complex Homo sapiens R-HSA-72695</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>29</th>\n",
       "      <td>4.829338e-08</td>\n",
       "      <td>Ribosomal scanning and start codon recognition Homo sapiens R-HSA-72702</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>30</th>\n",
       "      <td>4.673553e-08</td>\n",
       "      <td>Translation initiation complex formation Homo sapiens R-HSA-72649</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>31</th>\n",
       "      <td>4.952155e-08</td>\n",
       "      <td>Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Homo sapiens R-HSA-72662</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "    Adjusted P-value                                                                                                                             Term\n",
       "0       1.063434e-38                                                                                 Viral mRNA Translation Homo sapiens R-HSA-192823\n",
       "1       5.317171e-39                                                                               Peptide chain elongation Homo sapiens R-HSA-156902\n",
       "2       6.864293e-39                                                                              Selenocysteine synthesis Homo sapiens R-HSA-2408557\n",
       "3       5.148220e-39                                                                      Eukaryotic Translation Termination Homo sapiens R-HSA-72764\n",
       "4       6.310234e-39                                                                      Eukaryotic Translation Elongation Homo sapiens R-HSA-156842\n",
       "5       5.258529e-39                           Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Homo sapiens R-HSA-975956\n",
       "6       1.853563e-38                                                                Formation of a pool of free 40S subunits Homo sapiens R-HSA-72689\n",
       "7       1.016131e-37                                                                          Nonsense-Mediated Decay (NMD) Homo sapiens R-HSA-927802\n",
       "8       9.032274e-38                              Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Homo sapiens R-HSA-975957\n",
       "9       8.129047e-38                                      L13a-mediated translational silencing of Ceruloplasmin expression Homo sapiens R-HSA-156827\n",
       "10      7.390042e-38                                                              3' -UTR-mediated translational regulation Homo sapiens R-HSA-157279\n",
       "11      8.053898e-38                                           SRP-dependent cotranslational protein targeting to membrane Homo sapiens R-HSA-1799339\n",
       "12      7.434367e-38                                                 GTP hydrolysis and joining of the 60S ribosomal subunit Homo sapiens R-HSA-72706\n",
       "13      1.355846e-37                                                                           Selenoamino acid metabolism Homo sapiens R-HSA-2408522\n",
       "14      2.063954e-37                                                                    Cap-dependent Translation Initiation Homo sapiens R-HSA-72737\n",
       "15      1.934957e-37                                                                       Eukaryotic Translation Initiation Homo sapiens R-HSA-72613\n",
       "16      1.506743e-36                                                      Influenza Viral RNA Transcription and Replication Homo sapiens R-HSA-168273\n",
       "17      4.270615e-36                                                                                   Influenza Life Cycle Homo sapiens R-HSA-168255\n",
       "18      1.646512e-35                                                                                    Influenza Infection Homo sapiens R-HSA-168254\n",
       "19      2.535245e-35                                                                                             Translation Homo sapiens R-HSA-72766\n",
       "20      1.318658e-34                                                     Major pathway of rRNA processing in the nucleolus Homo sapiens R-HSA-6791226\n",
       "21      5.337596e-34                                                                                         rRNA processing Homo sapiens R-HSA-72312\n",
       "22      2.843663e-29                                                               Metabolism of amino acids and derivatives Homo sapiens R-HSA-71291\n",
       "23      5.288175e-29                                                                                    Infectious disease Homo sapiens R-HSA-5663205\n",
       "24      1.641292e-23                                                                                               Disease Homo sapiens R-HSA-1643685\n",
       "25      1.337958e-20                                                                                 Metabolism of proteins Homo sapiens R-HSA-392499\n",
       "26      1.635971e-17                                                                                         Gene Expression Homo sapiens R-HSA-74160\n",
       "27      2.298437e-16                                                                                            Metabolism Homo sapiens R-HSA-1430728\n",
       "28      2.536855e-08                                     Formation of the ternary complex, and subsequently, the 43S complex Homo sapiens R-HSA-72695\n",
       "29      4.829338e-08                                                          Ribosomal scanning and start codon recognition Homo sapiens R-HSA-72702\n",
       "30      4.673553e-08                                                                Translation initiation complex formation Homo sapiens R-HSA-72649\n",
       "31      4.952155e-08  Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Homo sapiens R-HSA-72662"
      ]
     },
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    },
    {
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     "output_type": "stream",
     "text": [
      "\n",
      "\n",
      "TMEM160 - C4orf48 - PRR7 - CCDC85B - PCSK1N - ZNF771 - TPGS1 - PDXP:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "MYH2 - MB - TNNT3 - MYL1 - MYL2 - CKM - TNNI1 - MYH1 - ACTA1:\n"
     ]
    },
    {
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       "      <th></th>\n",
       "      <th>Adjusted P-value</th>\n",
       "      <th>Term</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0.000001</td>\n",
       "      <td>Striated Muscle Contraction Homo sapiens R-HSA-390522</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>0.000830</td>\n",
       "      <td>Muscle contraction Homo sapiens R-HSA-397014</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "   Adjusted P-value                                                   Term\n",
       "0          0.000001  Striated Muscle Contraction Homo sapiens R-HSA-390522\n",
       "1          0.000830           Muscle contraction Homo sapiens R-HSA-397014"
      ]
     },
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    },
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     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\n",
      "\n",
      "SFTPB - SFTPA1:\n"
     ]
    },
    {
     "data": {
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       "<table border=\"1\" class=\"dataframe\">\n",
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       "      <th>Adjusted P-value</th>\n",
       "      <th>Term</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0.000076</td>\n",
       "      <td>Defective ABCA3 causes pulmonary surfactant metabolism dysfunction type 3 (SMDP3) Homo sapiens R-HSA-5683678</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>0.000107</td>\n",
       "      <td>Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) Homo sapiens R-HSA-5688849</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>0.000071</td>\n",
       "      <td>Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) Homo sapiens R-HSA-5688890</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>0.000054</td>\n",
       "      <td>ABC transporter disorders Homo sapiens R-HSA-5619084</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>0.000069</td>\n",
       "      <td>Diseases associated with surfactant metabolism Homo sapiens R-HSA-5687613</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>5</th>\n",
       "      <td>0.000134</td>\n",
       "      <td>Disorders of transmembrane transporters Homo sapiens R-HSA-5619115</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>0.000444</td>\n",
       "      <td>Surfactant metabolism Homo sapiens R-HSA-5683826</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7</th>\n",
       "      <td>0.000947</td>\n",
       "      <td>Diseases of metabolism Homo sapiens R-HSA-5668914</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "   Adjusted P-value                                                                                                          Term\n",
       "0          0.000076  Defective ABCA3 causes pulmonary surfactant metabolism dysfunction type 3 (SMDP3) Homo sapiens R-HSA-5683678\n",
       "1          0.000107      Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) Homo sapiens R-HSA-5688849\n",
       "2          0.000071      Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) Homo sapiens R-HSA-5688890\n",
       "3          0.000054                                                          ABC transporter disorders Homo sapiens R-HSA-5619084\n",
       "4          0.000069                                     Diseases associated with surfactant metabolism Homo sapiens R-HSA-5687613\n",
       "5          0.000134                                            Disorders of transmembrane transporters Homo sapiens R-HSA-5619115\n",
       "6          0.000444                                                              Surfactant metabolism Homo sapiens R-HSA-5683826\n",
       "7          0.000947                                                             Diseases of metabolism Homo sapiens R-HSA-5668914"
      ]
     },
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    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\n",
      "\n",
      "FGA - FGB - ORM1:\n"
     ]
    },
    {
     "data": {
      "text/html": [
       "<div>\n",
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       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>Adjusted P-value</th>\n",
       "      <th>Term</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0.000215</td>\n",
       "      <td>Platelet degranulation Homo sapiens R-HSA-114608</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>0.000124</td>\n",
       "      <td>Response to elevated platelet cytosolic Ca2+ Homo sapiens R-HSA-76005</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>0.000803</td>\n",
       "      <td>GRB2:SOS provides linkage to MAPK signaling for Integrins Homo sapiens R-HSA-354194</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>0.000602</td>\n",
       "      <td>p130Cas linkage to MAPK signaling for integrins Homo sapiens R-HSA-372708</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>0.000612</td>\n",
       "      <td>Platelet activation, signaling and aggregation Homo sapiens R-HSA-76002</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>62</th>\n",
       "      <td>0.027555</td>\n",
       "      <td>Signaling by Interleukins Homo sapiens R-HSA-449147</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>63</th>\n",
       "      <td>0.027539</td>\n",
       "      <td>Fc epsilon receptor (FCERI) signaling Homo sapiens R-HSA-2454202</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>64</th>\n",
       "      <td>0.032400</td>\n",
       "      <td>Gastrin-CREB signalling pathway via PKC and MAPK Homo sapiens R-HSA-881907</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>65</th>\n",
       "      <td>0.034606</td>\n",
       "      <td>Signalling by NGF Homo sapiens R-HSA-166520</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>66</th>\n",
       "      <td>0.044563</td>\n",
       "      <td>Axon guidance Homo sapiens R-HSA-422475</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>67 rows × 2 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "    Adjusted P-value                                                                                 Term\n",
       "0           0.000215                                     Platelet degranulation Homo sapiens R-HSA-114608\n",
       "1           0.000124                Response to elevated platelet cytosolic Ca2+ Homo sapiens R-HSA-76005\n",
       "2           0.000803  GRB2:SOS provides linkage to MAPK signaling for Integrins Homo sapiens R-HSA-354194\n",
       "3           0.000602            p130Cas linkage to MAPK signaling for integrins Homo sapiens R-HSA-372708\n",
       "4           0.000612              Platelet activation, signaling and aggregation Homo sapiens R-HSA-76002\n",
       "..               ...                                                                                  ...\n",
       "62          0.027555                                  Signaling by Interleukins Homo sapiens R-HSA-449147\n",
       "63          0.027539                     Fc epsilon receptor (FCERI) signaling Homo sapiens R-HSA-2454202\n",
       "64          0.032400           Gastrin-CREB signalling pathway via PKC and MAPK Homo sapiens R-HSA-881907\n",
       "65          0.034606                                          Signalling by NGF Homo sapiens R-HSA-166520\n",
       "66          0.044563                                              Axon guidance Homo sapiens R-HSA-422475\n",
       "\n",
       "[67 rows x 2 columns]"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\n",
      "\n",
      "HSPA1A - HSPA1B:\n"
     ]
    },
    {
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       "      <th></th>\n",
       "      <th>Adjusted P-value</th>\n",
       "      <th>Term</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0.002486</td>\n",
       "      <td>Attenuation phase Homo sapiens R-HSA-3371568</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>0.001553</td>\n",
       "      <td>HSF1 activation Homo sapiens R-HSA-3371511</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>0.001431</td>\n",
       "      <td>HSF1-dependent transactivation Homo sapiens R-HSA-3371571</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>0.006043</td>\n",
       "      <td>Regulation of HSF1-mediated heat shock response Homo sapiens R-HSA-3371453</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>0.006977</td>\n",
       "      <td>Cellular response to heat stress Homo sapiens R-HSA-3371556</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "   Adjusted P-value                                                                        Term\n",
       "0          0.002486                                Attenuation phase Homo sapiens R-HSA-3371568\n",
       "1          0.001553                                  HSF1 activation Homo sapiens R-HSA-3371511\n",
       "2          0.001431                   HSF1-dependent transactivation Homo sapiens R-HSA-3371571\n",
       "3          0.006043  Regulation of HSF1-mediated heat shock response Homo sapiens R-HSA-3371453\n",
       "4          0.006977                 Cellular response to heat stress Homo sapiens R-HSA-3371556"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\n",
      "\n",
      "LIPF - PGC:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "PRM2 - PRM1:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "COL4A2 - COL4A1:\n"
     ]
    },
    {
     "data": {
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       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>Adjusted P-value</th>\n",
       "      <th>Term</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0.001308</td>\n",
       "      <td>Scavenging by Class A Receptors Homo sapiens R-HSA-3000480</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>0.002547</td>\n",
       "      <td>NCAM1 interactions Homo sapiens R-HSA-419037</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>0.003649</td>\n",
       "      <td>Assembly of collagen fibrils and other multimeric structures Homo sapiens R-HSA-2022090</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>0.003735</td>\n",
       "      <td>Collagen biosynthesis and modifying enzymes Homo sapiens R-HSA-1650814</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>0.003383</td>\n",
       "      <td>Integrin cell surface interactions Homo sapiens R-HSA-216083</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>5</th>\n",
       "      <td>0.003444</td>\n",
       "      <td>Binding and Uptake of Ligands by Scavenger Receptors Homo sapiens R-HSA-2173782</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>0.003901</td>\n",
       "      <td>Collagen formation Homo sapiens R-HSA-1474290</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7</th>\n",
       "      <td>0.033704</td>\n",
       "      <td>NCAM signaling for neurite out-growth Homo sapiens R-HSA-375165</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8</th>\n",
       "      <td>0.033918</td>\n",
       "      <td>Extracellular matrix organization Homo sapiens R-HSA-1474244</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "   Adjusted P-value                                                                                     Term\n",
       "0          0.001308                               Scavenging by Class A Receptors Homo sapiens R-HSA-3000480\n",
       "1          0.002547                                             NCAM1 interactions Homo sapiens R-HSA-419037\n",
       "2          0.003649  Assembly of collagen fibrils and other multimeric structures Homo sapiens R-HSA-2022090\n",
       "3          0.003735                   Collagen biosynthesis and modifying enzymes Homo sapiens R-HSA-1650814\n",
       "4          0.003383                             Integrin cell surface interactions Homo sapiens R-HSA-216083\n",
       "5          0.003444          Binding and Uptake of Ligands by Scavenger Receptors Homo sapiens R-HSA-2173782\n",
       "6          0.003901                                            Collagen formation Homo sapiens R-HSA-1474290\n",
       "7          0.033704                          NCAM signaling for neurite out-growth Homo sapiens R-HSA-375165\n",
       "8          0.033918                             Extracellular matrix organization Homo sapiens R-HSA-1474244"
      ]
     },
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     "output_type": "display_data"
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\n",
      "\n",
      "OAS2 - IFI44L - IFI44 - OAS1:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "ACTA2 - MYH11 - MYL9:\n"
     ]
    },
    {
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       "      <th></th>\n",
       "      <th>Adjusted P-value</th>\n",
       "      <th>Term</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0.000006</td>\n",
       "      <td>Smooth Muscle Contraction Homo sapiens R-HSA-445355</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>0.000709</td>\n",
       "      <td>Muscle contraction Homo sapiens R-HSA-397014</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>0.000918</td>\n",
       "      <td>RHO GTPases activate CIT Homo sapiens R-HSA-5625900</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>0.000780</td>\n",
       "      <td>RHO GTPases Activate ROCKs Homo sapiens R-HSA-5627117</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>0.000963</td>\n",
       "      <td>RHO GTPases activate PAKs Homo sapiens R-HSA-5627123</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>5</th>\n",
       "      <td>0.001055</td>\n",
       "      <td>Sema4D induced cell migration and growth-cone collapse Homo sapiens R-HSA-416572</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>0.001150</td>\n",
       "      <td>Sema4D in semaphorin signaling Homo sapiens R-HSA-400685</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7</th>\n",
       "      <td>0.001608</td>\n",
       "      <td>EPHA-mediated growth cone collapse Homo sapiens R-HSA-3928663</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8</th>\n",
       "      <td>0.004505</td>\n",
       "      <td>RHO GTPases activate PKNs Homo sapiens R-HSA-5625740</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>9</th>\n",
       "      <td>0.005063</td>\n",
       "      <td>Semaphorin interactions Homo sapiens R-HSA-373755</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>10</th>\n",
       "      <td>0.009287</td>\n",
       "      <td>EPH-Ephrin signaling Homo sapiens R-HSA-2682334</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "    Adjusted P-value                                                                              Term\n",
       "0           0.000006                               Smooth Muscle Contraction Homo sapiens R-HSA-445355\n",
       "1           0.000709                                      Muscle contraction Homo sapiens R-HSA-397014\n",
       "2           0.000918                               RHO GTPases activate CIT Homo sapiens R-HSA-5625900\n",
       "3           0.000780                             RHO GTPases Activate ROCKs Homo sapiens R-HSA-5627117\n",
       "4           0.000963                              RHO GTPases activate PAKs Homo sapiens R-HSA-5627123\n",
       "5           0.001055  Sema4D induced cell migration and growth-cone collapse Homo sapiens R-HSA-416572\n",
       "6           0.001150                          Sema4D in semaphorin signaling Homo sapiens R-HSA-400685\n",
       "7           0.001608                     EPHA-mediated growth cone collapse Homo sapiens R-HSA-3928663\n",
       "8           0.004505                              RHO GTPases activate PKNs Homo sapiens R-HSA-5625740\n",
       "9           0.005063                                 Semaphorin interactions Homo sapiens R-HSA-373755\n",
       "10          0.009287                                   EPH-Ephrin signaling Homo sapiens R-HSA-2682334"
      ]
     },
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    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\n",
      "\n",
      "FCGR3B - CXCR1:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "C1QA - C1QB - C1QC:\n"
     ]
    },
    {
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       "      <th>Adjusted P-value</th>\n",
       "      <th>Term</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0.000014</td>\n",
       "      <td>Classical antibody-mediated complement activation Homo sapiens R-HSA-173623</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>0.000011</td>\n",
       "      <td>Creation of C4 and C2 activators Homo sapiens R-HSA-166786</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>0.000012</td>\n",
       "      <td>Initial triggering of complement Homo sapiens R-HSA-166663</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>0.000024</td>\n",
       "      <td>Complement cascade Homo sapiens R-HSA-166658</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>0.020030</td>\n",
       "      <td>Innate Immune System Homo sapiens R-HSA-168249</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "   Adjusted P-value                                                                         Term\n",
       "0          0.000014  Classical antibody-mediated complement activation Homo sapiens R-HSA-173623\n",
       "1          0.000011                   Creation of C4 and C2 activators Homo sapiens R-HSA-166786\n",
       "2          0.000012                   Initial triggering of complement Homo sapiens R-HSA-166663\n",
       "3          0.000024                                 Complement cascade Homo sapiens R-HSA-166658\n",
       "4          0.020030                               Innate Immune System Homo sapiens R-HSA-168249"
      ]
     },
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    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\n",
      "\n",
      "CASP14 - KRT2 - CALML5 - KRT1:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "MOBP - MBP:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "FOS - DUSP1:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "C21orf33 - PWP2:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "SPRR3 - KRT6A - CRNN - KRT13 - KRT4:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "S100A8 - S100A9:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "GH1 - PRL:\n"
     ]
    },
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       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0.000803</td>\n",
       "      <td>Prolactin receptor signaling Homo sapiens R-HSA-1170546</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>0.001056</td>\n",
       "      <td>Growth hormone receptor signaling Homo sapiens R-HSA-982772</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>0.001890</td>\n",
       "      <td>Nuclear signaling by ERBB4 Homo sapiens R-HSA-1251985</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
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      ],
      "text/plain": [
       "   Adjusted P-value                                                         Term\n",
       "0          0.000803      Prolactin receptor signaling Homo sapiens R-HSA-1170546\n",
       "1          0.001056  Growth hormone receptor signaling Homo sapiens R-HSA-982772\n",
       "2          0.001890        Nuclear signaling by ERBB4 Homo sapiens R-HSA-1251985"
      ]
     },
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    },
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     "name": "stdout",
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     "text": [
      "\n",
      "\n"
     ]
    }
   ],
   "source": [
    "all_brain = [\n",
    "    ['GP2', 'PNLIPRP1', 'CTRB1', 'PLA2G1B', 'CPB1', 'SPINK1', 'PNLIP', 'CTRC', 'CTRB2', 'CLPS', 'CELA3A', 'CELA2A', 'CPA1', 'REG1B', 'PRSS1', 'REG1A', 'SYCN', 'CELA3B'],\n",
    "    ['HBA2', 'ALAS2', 'HBD', 'HBB', 'HBA1'],\n",
    "    ['CD74', 'HLA.DRA'],\n",
    "    ['KDM5C', 'ZFX', 'DDX3X'],\n",
    "    ['RPS15A', 'RPL35A', 'RPS27'],\n",
    "    ['RPS12', 'RPL32', 'RPL26', 'RPL23', 'RPL11', 'RPL37A', 'RPL31', 'RPL30', 'RPL36A', 'RPL21', 'RPL13A', 'RPS21', 'RPS3A', 'RPS16', 'RPS29', 'RPL27A', 'RPL38'],\n",
    "    ['TMEM160', 'C4orf48', 'PRR7', 'CCDC85B', 'PCSK1N', 'ZNF771', 'TPGS1', 'PDXP'],\n",
    "    ['MYH2', 'MB', 'TNNT3', 'MYL1', 'MYL2', 'CKM', 'TNNI1', 'MYH1', 'ACTA1'],\n",
    "    ['SFTPB', 'SFTPA1'],\n",
    "    ['FGA', 'FGB', 'ORM1'],\n",
    "    ['HSPA1A', 'HSPA1B'],\n",
    "    ['LIPF', 'PGC'],\n",
    "    ['PRM2', 'PRM1'],\n",
    "    ['COL4A2', 'COL4A1'],\n",
    "    ['OAS2', 'IFI44L', 'IFI44', 'OAS1'],\n",
    "    ['ACTA2', 'MYH11', 'MYL9'],\n",
    "    ['FCGR3B', 'CXCR1'],\n",
    "    ['C1QA', 'C1QB', 'C1QC'],\n",
    "    ['CASP14', 'KRT2', 'CALML5', 'KRT1'],\n",
    "    ['MOBP', 'MBP'],\n",
    "    ['FOS', 'DUSP1'],\n",
    "    ['C21orf33', 'PWP2'],\n",
    "    ['SPRR3', 'KRT6A', 'CRNN', 'KRT13', 'KRT4'],\n",
    "    ['S100A8', 'S100A9'],\n",
    "    ['GH1', 'PRL']\n",
    "]\n",
    "\n",
    "print_lists_to_enrich(all_brain)"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Brain and Gastrointestinal Tissues"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 11,
   "metadata": {
    "scrolled": true
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "PLA2G1B - CELA3A - CPA1 - CTRC - CTRB2 - PNLIPRP1 - PNLIP - CLPS - CTRB1 - CELA3B - CPB1 - SYCN - CELA2A - PRSS1:\n"
     ]
    },
    {
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       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>Adjusted P-value</th>\n",
       "      <th>Term</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>6.487620e-07</td>\n",
       "      <td>Metabolism of vitamins and cofactors Homo sapiens R-HSA-196854</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>6.828671e-07</td>\n",
       "      <td>Cobalamin (Cbl, vitamin B12) transport and metabolism Homo sapiens R-HSA-196741</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>9.413429e-05</td>\n",
       "      <td>Digestion of dietary lipid Homo sapiens R-HSA-192456</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>1.998342e-04</td>\n",
       "      <td>Metabolism of water-soluble vitamins and cofactors Homo sapiens R-HSA-196849</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>4.094443e-04</td>\n",
       "      <td>Activation of Matrix Metalloproteinases Homo sapiens R-HSA-1592389</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>5</th>\n",
       "      <td>3.057548e-03</td>\n",
       "      <td>Metabolism Homo sapiens R-HSA-1430728</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>3.316334e-03</td>\n",
       "      <td>Lipid digestion, mobilization, and transport Homo sapiens R-HSA-73923</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7</th>\n",
       "      <td>9.654184e-03</td>\n",
       "      <td>Degradation of the extracellular matrix Homo sapiens R-HSA-1474228</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "   Adjusted P-value                                                                             Term\n",
       "0      6.487620e-07                   Metabolism of vitamins and cofactors Homo sapiens R-HSA-196854\n",
       "1      6.828671e-07  Cobalamin (Cbl, vitamin B12) transport and metabolism Homo sapiens R-HSA-196741\n",
       "2      9.413429e-05                             Digestion of dietary lipid Homo sapiens R-HSA-192456\n",
       "3      1.998342e-04     Metabolism of water-soluble vitamins and cofactors Homo sapiens R-HSA-196849\n",
       "4      4.094443e-04               Activation of Matrix Metalloproteinases Homo sapiens R-HSA-1592389\n",
       "5      3.057548e-03                                            Metabolism Homo sapiens R-HSA-1430728\n",
       "6      3.316334e-03            Lipid digestion, mobilization, and transport Homo sapiens R-HSA-73923\n",
       "7      9.654184e-03               Degradation of the extracellular matrix Homo sapiens R-HSA-1474228"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\n",
      "\n",
      "MYL1 - ACTA1 - MYL2 - CKM:\n"
     ]
    },
    {
     "data": {
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       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>Adjusted P-value</th>\n",
       "      <th>Term</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0.025695</td>\n",
       "      <td>Striated Muscle Contraction Homo sapiens R-HSA-390522</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "   Adjusted P-value                                                   Term\n",
       "0          0.025695  Striated Muscle Contraction Homo sapiens R-HSA-390522"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\n",
      "\n",
      "CD74 - HLA.DRA:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "RPS29 - RPL32 - RPL30 - RPL11 - RPL37A - RPL31 - RPL26 - RPL36A - RPL23 - RPL38 - RPS21 - RPL13A:\n"
     ]
    },
    {
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       "  <thead>\n",
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       "      <th></th>\n",
       "      <th>Adjusted P-value</th>\n",
       "      <th>Term</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>2.024125e-26</td>\n",
       "      <td>Viral mRNA Translation Homo sapiens R-HSA-192823</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>1.012063e-26</td>\n",
       "      <td>Peptide chain elongation Homo sapiens R-HSA-156902</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>1.059130e-26</td>\n",
       "      <td>Selenocysteine synthesis Homo sapiens R-HSA-2408557</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>7.943475e-27</td>\n",
       "      <td>Eukaryotic Translation Termination Homo sapiens R-HSA-72764</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>8.505050e-27</td>\n",
       "      <td>Eukaryotic Translation Elongation Homo sapiens R-HSA-156842</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>5</th>\n",
       "      <td>7.087541e-27</td>\n",
       "      <td>Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Homo sapiens R-HSA-975956</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>1.598764e-26</td>\n",
       "      <td>Formation of a pool of free 40S subunits Homo sapiens R-HSA-72689</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7</th>\n",
       "      <td>4.928950e-26</td>\n",
       "      <td>Nonsense-Mediated Decay (NMD) Homo sapiens R-HSA-927802</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8</th>\n",
       "      <td>4.381288e-26</td>\n",
       "      <td>Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Homo sapiens R-HSA-975957</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>9</th>\n",
       "      <td>3.943160e-26</td>\n",
       "      <td>L13a-mediated translational silencing of Ceruloplasmin expression Homo sapiens R-HSA-156827</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>10</th>\n",
       "      <td>3.584691e-26</td>\n",
       "      <td>3' -UTR-mediated translational regulation Homo sapiens R-HSA-157279</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>11</th>\n",
       "      <td>3.701062e-26</td>\n",
       "      <td>SRP-dependent cotranslational protein targeting to membrane Homo sapiens R-HSA-1799339</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>12</th>\n",
       "      <td>3.416365e-26</td>\n",
       "      <td>GTP hydrolysis and joining of the 60S ribosomal subunit Homo sapiens R-HSA-72706</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13</th>\n",
       "      <td>5.047234e-26</td>\n",
       "      <td>Selenoamino acid metabolism Homo sapiens R-HSA-2408522</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>14</th>\n",
       "      <td>6.597490e-26</td>\n",
       "      <td>Cap-dependent Translation Initiation Homo sapiens R-HSA-72737</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>15</th>\n",
       "      <td>6.185147e-26</td>\n",
       "      <td>Eukaryotic Translation Initiation Homo sapiens R-HSA-72613</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>16</th>\n",
       "      <td>2.500944e-25</td>\n",
       "      <td>Influenza Viral RNA Transcription and Replication Homo sapiens R-HSA-168273</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>17</th>\n",
       "      <td>5.049390e-25</td>\n",
       "      <td>Influenza Life Cycle Homo sapiens R-HSA-168255</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>18</th>\n",
       "      <td>1.264171e-24</td>\n",
       "      <td>Influenza Infection Homo sapiens R-HSA-168254</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>19</th>\n",
       "      <td>1.678419e-24</td>\n",
       "      <td>Translation Homo sapiens R-HSA-72766</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>20</th>\n",
       "      <td>5.192133e-24</td>\n",
       "      <td>Major pathway of rRNA processing in the nucleolus Homo sapiens R-HSA-6791226</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>21</th>\n",
       "      <td>1.352686e-23</td>\n",
       "      <td>rRNA processing Homo sapiens R-HSA-72312</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>22</th>\n",
       "      <td>2.663872e-20</td>\n",
       "      <td>Metabolism of amino acids and derivatives Homo sapiens R-HSA-71291</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>23</th>\n",
       "      <td>4.061838e-20</td>\n",
       "      <td>Infectious disease Homo sapiens R-HSA-5663205</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>24</th>\n",
       "      <td>2.882736e-16</td>\n",
       "      <td>Disease Homo sapiens R-HSA-1643685</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>25</th>\n",
       "      <td>3.190089e-14</td>\n",
       "      <td>Metabolism of proteins Homo sapiens R-HSA-392499</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>26</th>\n",
       "      <td>4.721123e-12</td>\n",
       "      <td>Gene Expression Homo sapiens R-HSA-74160</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>27</th>\n",
       "      <td>3.008356e-11</td>\n",
       "      <td>Metabolism Homo sapiens R-HSA-1430728</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>28</th>\n",
       "      <td>2.098952e-02</td>\n",
       "      <td>Formation of the ternary complex, and subsequently, the 43S complex Homo sapiens R-HSA-72695</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>29</th>\n",
       "      <td>2.637323e-02</td>\n",
       "      <td>Ribosomal scanning and start codon recognition Homo sapiens R-HSA-72702</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>30</th>\n",
       "      <td>2.552248e-02</td>\n",
       "      <td>Translation initiation complex formation Homo sapiens R-HSA-72649</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>31</th>\n",
       "      <td>2.559941e-02</td>\n",
       "      <td>Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Homo sapiens R-HSA-72662</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "    Adjusted P-value                                                                                                                             Term\n",
       "0       2.024125e-26                                                                                 Viral mRNA Translation Homo sapiens R-HSA-192823\n",
       "1       1.012063e-26                                                                               Peptide chain elongation Homo sapiens R-HSA-156902\n",
       "2       1.059130e-26                                                                              Selenocysteine synthesis Homo sapiens R-HSA-2408557\n",
       "3       7.943475e-27                                                                      Eukaryotic Translation Termination Homo sapiens R-HSA-72764\n",
       "4       8.505050e-27                                                                      Eukaryotic Translation Elongation Homo sapiens R-HSA-156842\n",
       "5       7.087541e-27                           Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Homo sapiens R-HSA-975956\n",
       "6       1.598764e-26                                                                Formation of a pool of free 40S subunits Homo sapiens R-HSA-72689\n",
       "7       4.928950e-26                                                                          Nonsense-Mediated Decay (NMD) Homo sapiens R-HSA-927802\n",
       "8       4.381288e-26                              Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Homo sapiens R-HSA-975957\n",
       "9       3.943160e-26                                      L13a-mediated translational silencing of Ceruloplasmin expression Homo sapiens R-HSA-156827\n",
       "10      3.584691e-26                                                              3' -UTR-mediated translational regulation Homo sapiens R-HSA-157279\n",
       "11      3.701062e-26                                           SRP-dependent cotranslational protein targeting to membrane Homo sapiens R-HSA-1799339\n",
       "12      3.416365e-26                                                 GTP hydrolysis and joining of the 60S ribosomal subunit Homo sapiens R-HSA-72706\n",
       "13      5.047234e-26                                                                           Selenoamino acid metabolism Homo sapiens R-HSA-2408522\n",
       "14      6.597490e-26                                                                    Cap-dependent Translation Initiation Homo sapiens R-HSA-72737\n",
       "15      6.185147e-26                                                                       Eukaryotic Translation Initiation Homo sapiens R-HSA-72613\n",
       "16      2.500944e-25                                                      Influenza Viral RNA Transcription and Replication Homo sapiens R-HSA-168273\n",
       "17      5.049390e-25                                                                                   Influenza Life Cycle Homo sapiens R-HSA-168255\n",
       "18      1.264171e-24                                                                                    Influenza Infection Homo sapiens R-HSA-168254\n",
       "19      1.678419e-24                                                                                             Translation Homo sapiens R-HSA-72766\n",
       "20      5.192133e-24                                                     Major pathway of rRNA processing in the nucleolus Homo sapiens R-HSA-6791226\n",
       "21      1.352686e-23                                                                                         rRNA processing Homo sapiens R-HSA-72312\n",
       "22      2.663872e-20                                                               Metabolism of amino acids and derivatives Homo sapiens R-HSA-71291\n",
       "23      4.061838e-20                                                                                    Infectious disease Homo sapiens R-HSA-5663205\n",
       "24      2.882736e-16                                                                                               Disease Homo sapiens R-HSA-1643685\n",
       "25      3.190089e-14                                                                                 Metabolism of proteins Homo sapiens R-HSA-392499\n",
       "26      4.721123e-12                                                                                         Gene Expression Homo sapiens R-HSA-74160\n",
       "27      3.008356e-11                                                                                            Metabolism Homo sapiens R-HSA-1430728\n",
       "28      2.098952e-02                                     Formation of the ternary complex, and subsequently, the 43S complex Homo sapiens R-HSA-72695\n",
       "29      2.637323e-02                                                          Ribosomal scanning and start codon recognition Homo sapiens R-HSA-72702\n",
       "30      2.552248e-02                                                                Translation initiation complex formation Homo sapiens R-HSA-72649\n",
       "31      2.559941e-02  Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Homo sapiens R-HSA-72662"
      ]
     },
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     "output_type": "stream",
     "text": [
      "\n",
      "\n",
      "SPRR3 - KRT4 - KRT13 - KRT6A - CRNN:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "GH1 - PRL:\n"
     ]
    },
    {
     "data": {
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       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>Adjusted P-value</th>\n",
       "      <th>Term</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0.000803</td>\n",
       "      <td>Prolactin receptor signaling Homo sapiens R-HSA-1170546</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>0.001056</td>\n",
       "      <td>Growth hormone receptor signaling Homo sapiens R-HSA-982772</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>0.001890</td>\n",
       "      <td>Nuclear signaling by ERBB4 Homo sapiens R-HSA-1251985</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "   Adjusted P-value                                                         Term\n",
       "0          0.000803      Prolactin receptor signaling Homo sapiens R-HSA-1170546\n",
       "1          0.001056  Growth hormone receptor signaling Homo sapiens R-HSA-982772\n",
       "2          0.001890        Nuclear signaling by ERBB4 Homo sapiens R-HSA-1251985"
      ]
     },
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    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\n",
      "\n",
      "LIPF - PGC:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "ORM1 - FGA - FGB:\n"
     ]
    },
    {
     "data": {
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       "      <th>Adjusted P-value</th>\n",
       "      <th>Term</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0.000215</td>\n",
       "      <td>Platelet degranulation Homo sapiens R-HSA-114608</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>0.000124</td>\n",
       "      <td>Response to elevated platelet cytosolic Ca2+ Homo sapiens R-HSA-76005</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>0.000803</td>\n",
       "      <td>GRB2:SOS provides linkage to MAPK signaling for Integrins Homo sapiens R-HSA-354194</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>0.000602</td>\n",
       "      <td>p130Cas linkage to MAPK signaling for integrins Homo sapiens R-HSA-372708</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>0.000612</td>\n",
       "      <td>Platelet activation, signaling and aggregation Homo sapiens R-HSA-76002</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>62</th>\n",
       "      <td>0.027555</td>\n",
       "      <td>Signaling by Interleukins Homo sapiens R-HSA-449147</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>63</th>\n",
       "      <td>0.027539</td>\n",
       "      <td>Fc epsilon receptor (FCERI) signaling Homo sapiens R-HSA-2454202</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>64</th>\n",
       "      <td>0.032400</td>\n",
       "      <td>Gastrin-CREB signalling pathway via PKC and MAPK Homo sapiens R-HSA-881907</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>65</th>\n",
       "      <td>0.034606</td>\n",
       "      <td>Signalling by NGF Homo sapiens R-HSA-166520</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>66</th>\n",
       "      <td>0.044563</td>\n",
       "      <td>Axon guidance Homo sapiens R-HSA-422475</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>67 rows × 2 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "    Adjusted P-value                                                                                 Term\n",
       "0           0.000215                                     Platelet degranulation Homo sapiens R-HSA-114608\n",
       "1           0.000124                Response to elevated platelet cytosolic Ca2+ Homo sapiens R-HSA-76005\n",
       "2           0.000803  GRB2:SOS provides linkage to MAPK signaling for Integrins Homo sapiens R-HSA-354194\n",
       "3           0.000602            p130Cas linkage to MAPK signaling for integrins Homo sapiens R-HSA-372708\n",
       "4           0.000612              Platelet activation, signaling and aggregation Homo sapiens R-HSA-76002\n",
       "..               ...                                                                                  ...\n",
       "62          0.027555                                  Signaling by Interleukins Homo sapiens R-HSA-449147\n",
       "63          0.027539                     Fc epsilon receptor (FCERI) signaling Homo sapiens R-HSA-2454202\n",
       "64          0.032400           Gastrin-CREB signalling pathway via PKC and MAPK Homo sapiens R-HSA-881907\n",
       "65          0.034606                                          Signalling by NGF Homo sapiens R-HSA-166520\n",
       "66          0.044563                                              Axon guidance Homo sapiens R-HSA-422475\n",
       "\n",
       "[67 rows x 2 columns]"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\n",
      "\n",
      "KDM5C - ZFX - DDX3X:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "RPS27 - RPL35A - RPS15A:\n"
     ]
    },
    {
     "data": {
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       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>Adjusted P-value</th>\n",
       "      <th>Term</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0.000109</td>\n",
       "      <td>Viral mRNA Translation Homo sapiens R-HSA-192823</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>0.000055</td>\n",
       "      <td>Peptide chain elongation Homo sapiens R-HSA-156902</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>0.000041</td>\n",
       "      <td>Selenocysteine synthesis Homo sapiens R-HSA-2408557</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>0.000030</td>\n",
       "      <td>Eukaryotic Translation Termination Homo sapiens R-HSA-72764</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>0.000026</td>\n",
       "      <td>Eukaryotic Translation Elongation Homo sapiens R-HSA-156842</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>5</th>\n",
       "      <td>0.000022</td>\n",
       "      <td>Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Homo sapiens R-HSA-975956</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>0.000023</td>\n",
       "      <td>Formation of a pool of free 40S subunits Homo sapiens R-HSA-72689</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7</th>\n",
       "      <td>0.000028</td>\n",
       "      <td>Nonsense-Mediated Decay (NMD) Homo sapiens R-HSA-927802</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8</th>\n",
       "      <td>0.000025</td>\n",
       "      <td>Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Homo sapiens R-HSA-975957</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>9</th>\n",
       "      <td>0.000022</td>\n",
       "      <td>L13a-mediated translational silencing of Ceruloplasmin expression Homo sapiens R-HSA-156827</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>10</th>\n",
       "      <td>0.000020</td>\n",
       "      <td>3' -UTR-mediated translational regulation Homo sapiens R-HSA-157279</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>11</th>\n",
       "      <td>0.000019</td>\n",
       "      <td>SRP-dependent cotranslational protein targeting to membrane Homo sapiens R-HSA-1799339</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>12</th>\n",
       "      <td>0.000018</td>\n",
       "      <td>GTP hydrolysis and joining of the 60S ribosomal subunit Homo sapiens R-HSA-72706</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13</th>\n",
       "      <td>0.000018</td>\n",
       "      <td>Selenoamino acid metabolism Homo sapiens R-HSA-2408522</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>14</th>\n",
       "      <td>0.000018</td>\n",
       "      <td>Cap-dependent Translation Initiation Homo sapiens R-HSA-72737</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>15</th>\n",
       "      <td>0.000017</td>\n",
       "      <td>Eukaryotic Translation Initiation Homo sapiens R-HSA-72613</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>16</th>\n",
       "      <td>0.000023</td>\n",
       "      <td>Influenza Viral RNA Transcription and Replication Homo sapiens R-HSA-168273</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>17</th>\n",
       "      <td>0.000026</td>\n",
       "      <td>Influenza Life Cycle Homo sapiens R-HSA-168255</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>18</th>\n",
       "      <td>0.000031</td>\n",
       "      <td>Influenza Infection Homo sapiens R-HSA-168254</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>19</th>\n",
       "      <td>0.000032</td>\n",
       "      <td>Translation Homo sapiens R-HSA-72766</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>20</th>\n",
       "      <td>0.000041</td>\n",
       "      <td>Major pathway of rRNA processing in the nucleolus Homo sapiens R-HSA-6791226</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>21</th>\n",
       "      <td>0.000050</td>\n",
       "      <td>rRNA processing Homo sapiens R-HSA-72312</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>22</th>\n",
       "      <td>0.000310</td>\n",
       "      <td>Metabolism of amino acids and derivatives Homo sapiens R-HSA-71291</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>23</th>\n",
       "      <td>0.000333</td>\n",
       "      <td>Infectious disease Homo sapiens R-HSA-5663205</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>24</th>\n",
       "      <td>0.001123</td>\n",
       "      <td>Formation of the ternary complex, and subsequently, the 43S complex Homo sapiens R-HSA-72695</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>25</th>\n",
       "      <td>0.001406</td>\n",
       "      <td>Ribosomal scanning and start codon recognition Homo sapiens R-HSA-72702</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>26</th>\n",
       "      <td>0.001354</td>\n",
       "      <td>Translation initiation complex formation Homo sapiens R-HSA-72649</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>27</th>\n",
       "      <td>0.001352</td>\n",
       "      <td>Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Homo sapiens R-HSA-72662</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>28</th>\n",
       "      <td>0.002503</td>\n",
       "      <td>Disease Homo sapiens R-HSA-1643685</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>29</th>\n",
       "      <td>0.007876</td>\n",
       "      <td>Metabolism of proteins Homo sapiens R-HSA-392499</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>30</th>\n",
       "      <td>0.026721</td>\n",
       "      <td>Gene Expression Homo sapiens R-HSA-74160</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>31</th>\n",
       "      <td>0.041453</td>\n",
       "      <td>Metabolism Homo sapiens R-HSA-1430728</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "    Adjusted P-value                                                                                                                             Term\n",
       "0           0.000109                                                                                 Viral mRNA Translation Homo sapiens R-HSA-192823\n",
       "1           0.000055                                                                               Peptide chain elongation Homo sapiens R-HSA-156902\n",
       "2           0.000041                                                                              Selenocysteine synthesis Homo sapiens R-HSA-2408557\n",
       "3           0.000030                                                                      Eukaryotic Translation Termination Homo sapiens R-HSA-72764\n",
       "4           0.000026                                                                      Eukaryotic Translation Elongation Homo sapiens R-HSA-156842\n",
       "5           0.000022                           Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Homo sapiens R-HSA-975956\n",
       "6           0.000023                                                                Formation of a pool of free 40S subunits Homo sapiens R-HSA-72689\n",
       "7           0.000028                                                                          Nonsense-Mediated Decay (NMD) Homo sapiens R-HSA-927802\n",
       "8           0.000025                              Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Homo sapiens R-HSA-975957\n",
       "9           0.000022                                      L13a-mediated translational silencing of Ceruloplasmin expression Homo sapiens R-HSA-156827\n",
       "10          0.000020                                                              3' -UTR-mediated translational regulation Homo sapiens R-HSA-157279\n",
       "11          0.000019                                           SRP-dependent cotranslational protein targeting to membrane Homo sapiens R-HSA-1799339\n",
       "12          0.000018                                                 GTP hydrolysis and joining of the 60S ribosomal subunit Homo sapiens R-HSA-72706\n",
       "13          0.000018                                                                           Selenoamino acid metabolism Homo sapiens R-HSA-2408522\n",
       "14          0.000018                                                                    Cap-dependent Translation Initiation Homo sapiens R-HSA-72737\n",
       "15          0.000017                                                                       Eukaryotic Translation Initiation Homo sapiens R-HSA-72613\n",
       "16          0.000023                                                      Influenza Viral RNA Transcription and Replication Homo sapiens R-HSA-168273\n",
       "17          0.000026                                                                                   Influenza Life Cycle Homo sapiens R-HSA-168255\n",
       "18          0.000031                                                                                    Influenza Infection Homo sapiens R-HSA-168254\n",
       "19          0.000032                                                                                             Translation Homo sapiens R-HSA-72766\n",
       "20          0.000041                                                     Major pathway of rRNA processing in the nucleolus Homo sapiens R-HSA-6791226\n",
       "21          0.000050                                                                                         rRNA processing Homo sapiens R-HSA-72312\n",
       "22          0.000310                                                               Metabolism of amino acids and derivatives Homo sapiens R-HSA-71291\n",
       "23          0.000333                                                                                    Infectious disease Homo sapiens R-HSA-5663205\n",
       "24          0.001123                                     Formation of the ternary complex, and subsequently, the 43S complex Homo sapiens R-HSA-72695\n",
       "25          0.001406                                                          Ribosomal scanning and start codon recognition Homo sapiens R-HSA-72702\n",
       "26          0.001354                                                                Translation initiation complex formation Homo sapiens R-HSA-72649\n",
       "27          0.001352  Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Homo sapiens R-HSA-72662\n",
       "28          0.002503                                                                                               Disease Homo sapiens R-HSA-1643685\n",
       "29          0.007876                                                                                 Metabolism of proteins Homo sapiens R-HSA-392499\n",
       "30          0.026721                                                                                         Gene Expression Homo sapiens R-HSA-74160\n",
       "31          0.041453                                                                                            Metabolism Homo sapiens R-HSA-1430728"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\n",
      "\n",
      "S100A8 - S100A9:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "FCGR3B - CXCR1:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "KRT2 - KRT1 - CASP14 - CALML5:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "MYH1 - MYH2:\n"
     ]
    },
    {
     "data": {
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       "      <th>Adjusted P-value</th>\n",
       "      <th>Term</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0.01354</td>\n",
       "      <td>Translocation of GLUT4 to the plasma membrane Homo sapiens R-HSA-1445148</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "   Adjusted P-value                                                                      Term\n",
       "0           0.01354  Translocation of GLUT4 to the plasma membrane Homo sapiens R-HSA-1445148"
      ]
     },
     "metadata": {},
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    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\n",
      "\n",
      "SFTPA1 - SFTPB:\n"
     ]
    },
    {
     "data": {
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       "<table border=\"1\" class=\"dataframe\">\n",
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       "      <th>Adjusted P-value</th>\n",
       "      <th>Term</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0.000076</td>\n",
       "      <td>Defective ABCA3 causes pulmonary surfactant metabolism dysfunction type 3 (SMDP3) Homo sapiens R-HSA-5683678</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>0.000107</td>\n",
       "      <td>Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) Homo sapiens R-HSA-5688849</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>0.000071</td>\n",
       "      <td>Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) Homo sapiens R-HSA-5688890</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>0.000054</td>\n",
       "      <td>ABC transporter disorders Homo sapiens R-HSA-5619084</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>0.000069</td>\n",
       "      <td>Diseases associated with surfactant metabolism Homo sapiens R-HSA-5687613</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>5</th>\n",
       "      <td>0.000134</td>\n",
       "      <td>Disorders of transmembrane transporters Homo sapiens R-HSA-5619115</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>0.000444</td>\n",
       "      <td>Surfactant metabolism Homo sapiens R-HSA-5683826</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7</th>\n",
       "      <td>0.000947</td>\n",
       "      <td>Diseases of metabolism Homo sapiens R-HSA-5668914</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "   Adjusted P-value                                                                                                          Term\n",
       "0          0.000076  Defective ABCA3 causes pulmonary surfactant metabolism dysfunction type 3 (SMDP3) Homo sapiens R-HSA-5683678\n",
       "1          0.000107      Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) Homo sapiens R-HSA-5688849\n",
       "2          0.000071      Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) Homo sapiens R-HSA-5688890\n",
       "3          0.000054                                                          ABC transporter disorders Homo sapiens R-HSA-5619084\n",
       "4          0.000069                                     Diseases associated with surfactant metabolism Homo sapiens R-HSA-5687613\n",
       "5          0.000134                                            Disorders of transmembrane transporters Homo sapiens R-HSA-5619115\n",
       "6          0.000444                                                              Surfactant metabolism Homo sapiens R-HSA-5683826\n",
       "7          0.000947                                                             Diseases of metabolism Homo sapiens R-HSA-5668914"
      ]
     },
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    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\n",
      "\n",
      "PRM2 - PRM1:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "REG1B - REG1A:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "DUSP1 - FOS:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "HBA1 - HBB - HBA2:\n"
     ]
    },
    {
     "data": {
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       "      <th>Adjusted P-value</th>\n",
       "      <th>Term</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0.000642</td>\n",
       "      <td>Erythrocytes take up oxygen and release carbon dioxide Homo sapiens R-HSA-1247673</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>0.000757</td>\n",
       "      <td>Erythrocytes take up carbon dioxide and release oxygen Homo sapiens R-HSA-1237044</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>0.000505</td>\n",
       "      <td>O2/CO2 exchange in erythrocytes Homo sapiens R-HSA-1480926</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>0.005930</td>\n",
       "      <td>Scavenging of heme from plasma Homo sapiens R-HSA-2168880</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>0.012368</td>\n",
       "      <td>Binding and Uptake of Ligands by Scavenger Receptors Homo sapiens R-HSA-2173782</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "   Adjusted P-value                                                                               Term\n",
       "0          0.000642  Erythrocytes take up oxygen and release carbon dioxide Homo sapiens R-HSA-1247673\n",
       "1          0.000757  Erythrocytes take up carbon dioxide and release oxygen Homo sapiens R-HSA-1237044\n",
       "2          0.000505                         O2/CO2 exchange in erythrocytes Homo sapiens R-HSA-1480926\n",
       "3          0.005930                          Scavenging of heme from plasma Homo sapiens R-HSA-2168880\n",
       "4          0.012368    Binding and Uptake of Ligands by Scavenger Receptors Homo sapiens R-HSA-2173782"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\n",
      "\n",
      "C21orf33 - PWP2:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "TMEM160 - TPGS1:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "IFI44L - IFI44:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "C1QB - C1QC - C1QA:\n"
     ]
    },
    {
     "data": {
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       "      <th></th>\n",
       "      <th>Adjusted P-value</th>\n",
       "      <th>Term</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0.000014</td>\n",
       "      <td>Classical antibody-mediated complement activation Homo sapiens R-HSA-173623</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>0.000011</td>\n",
       "      <td>Creation of C4 and C2 activators Homo sapiens R-HSA-166786</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>0.000012</td>\n",
       "      <td>Initial triggering of complement Homo sapiens R-HSA-166663</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>0.000024</td>\n",
       "      <td>Complement cascade Homo sapiens R-HSA-166658</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>0.020030</td>\n",
       "      <td>Innate Immune System Homo sapiens R-HSA-168249</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "   Adjusted P-value                                                                         Term\n",
       "0          0.000014  Classical antibody-mediated complement activation Homo sapiens R-HSA-173623\n",
       "1          0.000011                   Creation of C4 and C2 activators Homo sapiens R-HSA-166786\n",
       "2          0.000012                   Initial triggering of complement Homo sapiens R-HSA-166663\n",
       "3          0.000024                                 Complement cascade Homo sapiens R-HSA-166658\n",
       "4          0.020030                               Innate Immune System Homo sapiens R-HSA-168249"
      ]
     },
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    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\n",
      "\n",
      "HSPA1B - HSPA1A:\n"
     ]
    },
    {
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       "      <th></th>\n",
       "      <th>Adjusted P-value</th>\n",
       "      <th>Term</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0.002486</td>\n",
       "      <td>Attenuation phase Homo sapiens R-HSA-3371568</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>0.001553</td>\n",
       "      <td>HSF1 activation Homo sapiens R-HSA-3371511</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>0.001431</td>\n",
       "      <td>HSF1-dependent transactivation Homo sapiens R-HSA-3371571</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>0.006043</td>\n",
       "      <td>Regulation of HSF1-mediated heat shock response Homo sapiens R-HSA-3371453</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>0.006977</td>\n",
       "      <td>Cellular response to heat stress Homo sapiens R-HSA-3371556</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "   Adjusted P-value                                                                        Term\n",
       "0          0.002486                                Attenuation phase Homo sapiens R-HSA-3371568\n",
       "1          0.001553                                  HSF1 activation Homo sapiens R-HSA-3371511\n",
       "2          0.001431                   HSF1-dependent transactivation Homo sapiens R-HSA-3371571\n",
       "3          0.006043  Regulation of HSF1-mediated heat shock response Homo sapiens R-HSA-3371453\n",
       "4          0.006977                 Cellular response to heat stress Homo sapiens R-HSA-3371556"
      ]
     },
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    },
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     "output_type": "stream",
     "text": [
      "\n",
      "\n"
     ]
    }
   ],
   "source": [
    "brain_intestines = [\n",
    "    ['PLA2G1B', 'CELA3A', 'CPA1', 'CTRC', 'CTRB2', 'PNLIPRP1', 'PNLIP', 'CLPS', 'CTRB1', 'CELA3B', 'CPB1', 'SYCN', 'CELA2A', 'PRSS1'],\n",
    "    ['MYL1', 'ACTA1', 'MYL2', 'CKM'],\n",
    "    ['CD74', 'HLA.DRA'],\n",
    "    ['RPS29', 'RPL32', 'RPL30', 'RPL11', 'RPL37A', 'RPL31', 'RPL26', 'RPL36A', 'RPL23', 'RPL38', 'RPS21', 'RPL13A'],\n",
    "    ['SPRR3', 'KRT4', 'KRT13', 'KRT6A', 'CRNN'],\n",
    "    ['GH1', 'PRL'],\n",
    "    ['LIPF', 'PGC'],\n",
    "    ['ORM1', 'FGA', 'FGB'],\n",
    "    ['KDM5C', 'ZFX', 'DDX3X'],\n",
    "    ['RPS27', 'RPL35A', 'RPS15A'],\n",
    "    ['S100A8', 'S100A9'],\n",
    "    ['FCGR3B', 'CXCR1'],\n",
    "    ['KRT2', 'KRT1', 'CASP14', 'CALML5'],\n",
    "    ['MYH1', 'MYH2'],\n",
    "    ['SFTPA1', 'SFTPB'],\n",
    "    ['PRM2', 'PRM1'],\n",
    "    ['REG1B', 'REG1A'],\n",
    "    ['DUSP1', 'FOS'],\n",
    "    ['HBA1', 'HBB', 'HBA2'],\n",
    "    ['C21orf33', 'PWP2'],\n",
    "    ['TMEM160', 'TPGS1'],\n",
    "    ['IFI44L', 'IFI44'],\n",
    "    ['C1QB', 'C1QC', 'C1QA'],\n",
    "    ['HSPA1B', 'HSPA1A']\n",
    "]\n",
    "\n",
    "print_lists_to_enrich(brain_intestines)"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Brain Tissues and Whole Blood"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 3,
   "metadata": {
    "scrolled": true
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "RPL38 - RPL13A - RPL37A - RPL27A:\n"
     ]
    },
    {
     "data": {
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       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>Adjusted P-value</th>\n",
       "      <th>Term</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>4.428515e-07</td>\n",
       "      <td>Viral mRNA Translation Homo sapiens R-HSA-192823</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>2.214257e-07</td>\n",
       "      <td>Peptide chain elongation Homo sapiens R-HSA-156902</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>1.702934e-07</td>\n",
       "      <td>Selenocysteine synthesis Homo sapiens R-HSA-2408557</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>1.277200e-07</td>\n",
       "      <td>Eukaryotic Translation Termination Homo sapiens R-HSA-72764</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>1.120790e-07</td>\n",
       "      <td>Eukaryotic Translation Elongation Homo sapiens R-HSA-156842</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>5</th>\n",
       "      <td>9.339919e-08</td>\n",
       "      <td>Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Homo sapiens R-HSA-975956</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>1.089217e-07</td>\n",
       "      <td>Formation of a pool of free 40S subunits Homo sapiens R-HSA-72689</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7</th>\n",
       "      <td>1.425233e-07</td>\n",
       "      <td>Nonsense-Mediated Decay (NMD) Homo sapiens R-HSA-927802</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8</th>\n",
       "      <td>1.266874e-07</td>\n",
       "      <td>Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Homo sapiens R-HSA-975957</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>9</th>\n",
       "      <td>1.140187e-07</td>\n",
       "      <td>L13a-mediated translational silencing of Ceruloplasmin expression Homo sapiens R-HSA-156827</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>10</th>\n",
       "      <td>1.036533e-07</td>\n",
       "      <td>3' -UTR-mediated translational regulation Homo sapiens R-HSA-157279</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>11</th>\n",
       "      <td>9.870556e-08</td>\n",
       "      <td>SRP-dependent cotranslational protein targeting to membrane Homo sapiens R-HSA-1799339</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>12</th>\n",
       "      <td>9.111283e-08</td>\n",
       "      <td>GTP hydrolysis and joining of the 60S ribosomal subunit Homo sapiens R-HSA-72706</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13</th>\n",
       "      <td>9.818605e-08</td>\n",
       "      <td>Selenoamino acid metabolism Homo sapiens R-HSA-2408522</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>14</th>\n",
       "      <td>1.021047e-07</td>\n",
       "      <td>Cap-dependent Translation Initiation Homo sapiens R-HSA-72737</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>15</th>\n",
       "      <td>9.572318e-08</td>\n",
       "      <td>Eukaryotic Translation Initiation Homo sapiens R-HSA-72613</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>16</th>\n",
       "      <td>1.440330e-07</td>\n",
       "      <td>Influenza Viral RNA Transcription and Replication Homo sapiens R-HSA-168273</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>17</th>\n",
       "      <td>1.738503e-07</td>\n",
       "      <td>Influenza Life Cycle Homo sapiens R-HSA-168255</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>18</th>\n",
       "      <td>2.255633e-07</td>\n",
       "      <td>Influenza Infection Homo sapiens R-HSA-168254</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>19</th>\n",
       "      <td>2.388408e-07</td>\n",
       "      <td>Translation Homo sapiens R-HSA-72766</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>20</th>\n",
       "      <td>3.334491e-07</td>\n",
       "      <td>Major pathway of rRNA processing in the nucleolus Homo sapiens R-HSA-6791226</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>21</th>\n",
       "      <td>4.412900e-07</td>\n",
       "      <td>rRNA processing Homo sapiens R-HSA-72312</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>22</th>\n",
       "      <td>5.143894e-06</td>\n",
       "      <td>Metabolism of amino acids and derivatives Homo sapiens R-HSA-71291</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>23</th>\n",
       "      <td>5.744337e-06</td>\n",
       "      <td>Infectious disease Homo sapiens R-HSA-5663205</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>24</th>\n",
       "      <td>1.048280e-04</td>\n",
       "      <td>Disease Homo sapiens R-HSA-1643685</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>25</th>\n",
       "      <td>4.867302e-04</td>\n",
       "      <td>Metabolism of proteins Homo sapiens R-HSA-392499</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>26</th>\n",
       "      <td>2.497665e-03</td>\n",
       "      <td>Gene Expression Homo sapiens R-HSA-74160</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>27</th>\n",
       "      <td>4.513073e-03</td>\n",
       "      <td>Metabolism Homo sapiens R-HSA-1430728</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "    Adjusted P-value                                                                                                    Term\n",
       "0       4.428515e-07                                                        Viral mRNA Translation Homo sapiens R-HSA-192823\n",
       "1       2.214257e-07                                                      Peptide chain elongation Homo sapiens R-HSA-156902\n",
       "2       1.702934e-07                                                     Selenocysteine synthesis Homo sapiens R-HSA-2408557\n",
       "3       1.277200e-07                                             Eukaryotic Translation Termination Homo sapiens R-HSA-72764\n",
       "4       1.120790e-07                                             Eukaryotic Translation Elongation Homo sapiens R-HSA-156842\n",
       "5       9.339919e-08  Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Homo sapiens R-HSA-975956\n",
       "6       1.089217e-07                                       Formation of a pool of free 40S subunits Homo sapiens R-HSA-72689\n",
       "7       1.425233e-07                                                 Nonsense-Mediated Decay (NMD) Homo sapiens R-HSA-927802\n",
       "8       1.266874e-07     Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Homo sapiens R-HSA-975957\n",
       "9       1.140187e-07             L13a-mediated translational silencing of Ceruloplasmin expression Homo sapiens R-HSA-156827\n",
       "10      1.036533e-07                                     3' -UTR-mediated translational regulation Homo sapiens R-HSA-157279\n",
       "11      9.870556e-08                  SRP-dependent cotranslational protein targeting to membrane Homo sapiens R-HSA-1799339\n",
       "12      9.111283e-08                        GTP hydrolysis and joining of the 60S ribosomal subunit Homo sapiens R-HSA-72706\n",
       "13      9.818605e-08                                                  Selenoamino acid metabolism Homo sapiens R-HSA-2408522\n",
       "14      1.021047e-07                                           Cap-dependent Translation Initiation Homo sapiens R-HSA-72737\n",
       "15      9.572318e-08                                              Eukaryotic Translation Initiation Homo sapiens R-HSA-72613\n",
       "16      1.440330e-07                             Influenza Viral RNA Transcription and Replication Homo sapiens R-HSA-168273\n",
       "17      1.738503e-07                                                          Influenza Life Cycle Homo sapiens R-HSA-168255\n",
       "18      2.255633e-07                                                           Influenza Infection Homo sapiens R-HSA-168254\n",
       "19      2.388408e-07                                                                    Translation Homo sapiens R-HSA-72766\n",
       "20      3.334491e-07                            Major pathway of rRNA processing in the nucleolus Homo sapiens R-HSA-6791226\n",
       "21      4.412900e-07                                                                rRNA processing Homo sapiens R-HSA-72312\n",
       "22      5.143894e-06                                      Metabolism of amino acids and derivatives Homo sapiens R-HSA-71291\n",
       "23      5.744337e-06                                                           Infectious disease Homo sapiens R-HSA-5663205\n",
       "24      1.048280e-04                                                                      Disease Homo sapiens R-HSA-1643685\n",
       "25      4.867302e-04                                                        Metabolism of proteins Homo sapiens R-HSA-392499\n",
       "26      2.497665e-03                                                                Gene Expression Homo sapiens R-HSA-74160\n",
       "27      4.513073e-03                                                                   Metabolism Homo sapiens R-HSA-1430728"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\n",
      "\n",
      "REG1A - SYCN - PLA2G1B - CELA2A - CTRB2 - CTRB1 - CELA3B - CELA3A - CPB1 - PNLIP - PRSS1 - REG1B - CPA1 - GP2 - PNLIPRP1 - CLPS:\n"
     ]
    },
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       "      <th>Adjusted P-value</th>\n",
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       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0.000130</td>\n",
       "      <td>Metabolism of vitamins and cofactors Homo sapiens R-HSA-196854</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>0.000217</td>\n",
       "      <td>Digestion of dietary lipid Homo sapiens R-HSA-192456</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>0.000282</td>\n",
       "      <td>Cobalamin (Cbl, vitamin B12) transport and metabolism Homo sapiens R-HSA-196741</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>0.000786</td>\n",
       "      <td>Activation of Matrix Metalloproteinases Homo sapiens R-HSA-1592389</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>0.007107</td>\n",
       "      <td>Lipid digestion, mobilization, and transport Homo sapiens R-HSA-73923</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>5</th>\n",
       "      <td>0.015553</td>\n",
       "      <td>Metabolism of water-soluble vitamins and cofactors Homo sapiens R-HSA-196849</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>0.016844</td>\n",
       "      <td>Degradation of the extracellular matrix Homo sapiens R-HSA-1474228</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "   Adjusted P-value                                                                             Term\n",
       "0          0.000130                   Metabolism of vitamins and cofactors Homo sapiens R-HSA-196854\n",
       "1          0.000217                             Digestion of dietary lipid Homo sapiens R-HSA-192456\n",
       "2          0.000282  Cobalamin (Cbl, vitamin B12) transport and metabolism Homo sapiens R-HSA-196741\n",
       "3          0.000786               Activation of Matrix Metalloproteinases Homo sapiens R-HSA-1592389\n",
       "4          0.007107            Lipid digestion, mobilization, and transport Homo sapiens R-HSA-73923\n",
       "5          0.015553     Metabolism of water-soluble vitamins and cofactors Homo sapiens R-HSA-196849\n",
       "6          0.016844               Degradation of the extracellular matrix Homo sapiens R-HSA-1474228"
      ]
     },
     "metadata": {},
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    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\n",
      "\n",
      "PWP2 - C21orf33:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "CKM - MYL2 - ACTA1 - MYH2 - TNNI1 - MB - MYL1:\n"
     ]
    },
    {
     "data": {
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       "  <thead>\n",
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       "      <th></th>\n",
       "      <th>Adjusted P-value</th>\n",
       "      <th>Term</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0.000239</td>\n",
       "      <td>Striated Muscle Contraction Homo sapiens R-HSA-390522</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>0.024108</td>\n",
       "      <td>Muscle contraction Homo sapiens R-HSA-397014</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "   Adjusted P-value                                                   Term\n",
       "0          0.000239  Striated Muscle Contraction Homo sapiens R-HSA-390522\n",
       "1          0.024108           Muscle contraction Homo sapiens R-HSA-397014"
      ]
     },
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    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\n",
      "\n",
      "C1QB - C1QA - C1QC:\n"
     ]
    },
    {
     "data": {
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       "      <th></th>\n",
       "      <th>Adjusted P-value</th>\n",
       "      <th>Term</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0.000014</td>\n",
       "      <td>Classical antibody-mediated complement activation Homo sapiens R-HSA-173623</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>0.000011</td>\n",
       "      <td>Creation of C4 and C2 activators Homo sapiens R-HSA-166786</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>0.000012</td>\n",
       "      <td>Initial triggering of complement Homo sapiens R-HSA-166663</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>0.000024</td>\n",
       "      <td>Complement cascade Homo sapiens R-HSA-166658</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>0.020030</td>\n",
       "      <td>Innate Immune System Homo sapiens R-HSA-168249</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "   Adjusted P-value                                                                         Term\n",
       "0          0.000014  Classical antibody-mediated complement activation Homo sapiens R-HSA-173623\n",
       "1          0.000011                   Creation of C4 and C2 activators Homo sapiens R-HSA-166786\n",
       "2          0.000012                   Initial triggering of complement Homo sapiens R-HSA-166663\n",
       "3          0.000024                                 Complement cascade Homo sapiens R-HSA-166658\n",
       "4          0.020030                               Innate Immune System Homo sapiens R-HSA-168249"
      ]
     },
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     "output_type": "display_data"
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\n",
      "\n",
      "KRT13 - KRT4 - CRNN - SPRR3:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "RPS3A - RPL31 - RPL32 - RPL23 - RPS29 - RPL30 - RPS21:\n"
     ]
    },
    {
     "data": {
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       "  <thead>\n",
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       "      <th></th>\n",
       "      <th>Adjusted P-value</th>\n",
       "      <th>Term</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>2.729590e-14</td>\n",
       "      <td>Viral mRNA Translation Homo sapiens R-HSA-192823</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>1.364795e-14</td>\n",
       "      <td>Peptide chain elongation Homo sapiens R-HSA-156902</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>1.173830e-14</td>\n",
       "      <td>Selenocysteine synthesis Homo sapiens R-HSA-2408557</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>8.803725e-15</td>\n",
       "      <td>Eukaryotic Translation Termination Homo sapiens R-HSA-72764</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>8.304871e-15</td>\n",
       "      <td>Eukaryotic Translation Elongation Homo sapiens R-HSA-156842</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>5</th>\n",
       "      <td>6.920726e-15</td>\n",
       "      <td>Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Homo sapiens R-HSA-975956</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>1.026181e-14</td>\n",
       "      <td>Formation of a pool of free 40S subunits Homo sapiens R-HSA-72689</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7</th>\n",
       "      <td>1.835917e-14</td>\n",
       "      <td>Nonsense-Mediated Decay (NMD) Homo sapiens R-HSA-927802</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8</th>\n",
       "      <td>1.631926e-14</td>\n",
       "      <td>Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Homo sapiens R-HSA-975957</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>9</th>\n",
       "      <td>1.468734e-14</td>\n",
       "      <td>L13a-mediated translational silencing of Ceruloplasmin expression Homo sapiens R-HSA-156827</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>10</th>\n",
       "      <td>1.335213e-14</td>\n",
       "      <td>3' -UTR-mediated translational regulation Homo sapiens R-HSA-157279</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>11</th>\n",
       "      <td>1.309624e-14</td>\n",
       "      <td>SRP-dependent cotranslational protein targeting to membrane Homo sapiens R-HSA-1799339</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>12</th>\n",
       "      <td>1.208884e-14</td>\n",
       "      <td>GTP hydrolysis and joining of the 60S ribosomal subunit Homo sapiens R-HSA-72706</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13</th>\n",
       "      <td>1.462102e-14</td>\n",
       "      <td>Selenoamino acid metabolism Homo sapiens R-HSA-2408522</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>14</th>\n",
       "      <td>1.653255e-14</td>\n",
       "      <td>Cap-dependent Translation Initiation Homo sapiens R-HSA-72737</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>15</th>\n",
       "      <td>1.549926e-14</td>\n",
       "      <td>Eukaryotic Translation Initiation Homo sapiens R-HSA-72613</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>16</th>\n",
       "      <td>3.351260e-14</td>\n",
       "      <td>Influenza Viral RNA Transcription and Replication Homo sapiens R-HSA-168273</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>17</th>\n",
       "      <td>4.886835e-14</td>\n",
       "      <td>Influenza Life Cycle Homo sapiens R-HSA-168255</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>18</th>\n",
       "      <td>8.075717e-14</td>\n",
       "      <td>Influenza Infection Homo sapiens R-HSA-168254</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>19</th>\n",
       "      <td>9.294321e-14</td>\n",
       "      <td>Translation Homo sapiens R-HSA-72766</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>20</th>\n",
       "      <td>1.740074e-13</td>\n",
       "      <td>Major pathway of rRNA processing in the nucleolus Homo sapiens R-HSA-6791226</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>21</th>\n",
       "      <td>2.957378e-13</td>\n",
       "      <td>rRNA processing Homo sapiens R-HSA-72312</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>22</th>\n",
       "      <td>2.311802e-11</td>\n",
       "      <td>Metabolism of amino acids and derivatives Homo sapiens R-HSA-71291</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>23</th>\n",
       "      <td>2.898956e-11</td>\n",
       "      <td>Infectious disease Homo sapiens R-HSA-5663205</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>24</th>\n",
       "      <td>4.893666e-09</td>\n",
       "      <td>Disease Homo sapiens R-HSA-1643685</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>25</th>\n",
       "      <td>7.437008e-08</td>\n",
       "      <td>Metabolism of proteins Homo sapiens R-HSA-392499</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>26</th>\n",
       "      <td>1.343038e-06</td>\n",
       "      <td>Gene Expression Homo sapiens R-HSA-74160</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>27</th>\n",
       "      <td>3.890331e-06</td>\n",
       "      <td>Metabolism Homo sapiens R-HSA-1430728</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>28</th>\n",
       "      <td>2.695478e-05</td>\n",
       "      <td>Formation of the ternary complex, and subsequently, the 43S complex Homo sapiens R-HSA-72695</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>29</th>\n",
       "      <td>3.885763e-05</td>\n",
       "      <td>Ribosomal scanning and start codon recognition Homo sapiens R-HSA-72702</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>30</th>\n",
       "      <td>3.760416e-05</td>\n",
       "      <td>Translation initiation complex formation Homo sapiens R-HSA-72649</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>31</th>\n",
       "      <td>3.841032e-05</td>\n",
       "      <td>Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Homo sapiens R-HSA-72662</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "    Adjusted P-value                                                                                                                             Term\n",
       "0       2.729590e-14                                                                                 Viral mRNA Translation Homo sapiens R-HSA-192823\n",
       "1       1.364795e-14                                                                               Peptide chain elongation Homo sapiens R-HSA-156902\n",
       "2       1.173830e-14                                                                              Selenocysteine synthesis Homo sapiens R-HSA-2408557\n",
       "3       8.803725e-15                                                                      Eukaryotic Translation Termination Homo sapiens R-HSA-72764\n",
       "4       8.304871e-15                                                                      Eukaryotic Translation Elongation Homo sapiens R-HSA-156842\n",
       "5       6.920726e-15                           Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Homo sapiens R-HSA-975956\n",
       "6       1.026181e-14                                                                Formation of a pool of free 40S subunits Homo sapiens R-HSA-72689\n",
       "7       1.835917e-14                                                                          Nonsense-Mediated Decay (NMD) Homo sapiens R-HSA-927802\n",
       "8       1.631926e-14                              Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Homo sapiens R-HSA-975957\n",
       "9       1.468734e-14                                      L13a-mediated translational silencing of Ceruloplasmin expression Homo sapiens R-HSA-156827\n",
       "10      1.335213e-14                                                              3' -UTR-mediated translational regulation Homo sapiens R-HSA-157279\n",
       "11      1.309624e-14                                           SRP-dependent cotranslational protein targeting to membrane Homo sapiens R-HSA-1799339\n",
       "12      1.208884e-14                                                 GTP hydrolysis and joining of the 60S ribosomal subunit Homo sapiens R-HSA-72706\n",
       "13      1.462102e-14                                                                           Selenoamino acid metabolism Homo sapiens R-HSA-2408522\n",
       "14      1.653255e-14                                                                    Cap-dependent Translation Initiation Homo sapiens R-HSA-72737\n",
       "15      1.549926e-14                                                                       Eukaryotic Translation Initiation Homo sapiens R-HSA-72613\n",
       "16      3.351260e-14                                                      Influenza Viral RNA Transcription and Replication Homo sapiens R-HSA-168273\n",
       "17      4.886835e-14                                                                                   Influenza Life Cycle Homo sapiens R-HSA-168255\n",
       "18      8.075717e-14                                                                                    Influenza Infection Homo sapiens R-HSA-168254\n",
       "19      9.294321e-14                                                                                             Translation Homo sapiens R-HSA-72766\n",
       "20      1.740074e-13                                                     Major pathway of rRNA processing in the nucleolus Homo sapiens R-HSA-6791226\n",
       "21      2.957378e-13                                                                                         rRNA processing Homo sapiens R-HSA-72312\n",
       "22      2.311802e-11                                                               Metabolism of amino acids and derivatives Homo sapiens R-HSA-71291\n",
       "23      2.898956e-11                                                                                    Infectious disease Homo sapiens R-HSA-5663205\n",
       "24      4.893666e-09                                                                                               Disease Homo sapiens R-HSA-1643685\n",
       "25      7.437008e-08                                                                                 Metabolism of proteins Homo sapiens R-HSA-392499\n",
       "26      1.343038e-06                                                                                         Gene Expression Homo sapiens R-HSA-74160\n",
       "27      3.890331e-06                                                                                            Metabolism Homo sapiens R-HSA-1430728\n",
       "28      2.695478e-05                                     Formation of the ternary complex, and subsequently, the 43S complex Homo sapiens R-HSA-72695\n",
       "29      3.885763e-05                                                          Ribosomal scanning and start codon recognition Homo sapiens R-HSA-72702\n",
       "30      3.760416e-05                                                                Translation initiation complex formation Homo sapiens R-HSA-72649\n",
       "31      3.841032e-05  Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Homo sapiens R-HSA-72662"
      ]
     },
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    {
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     "text": [
      "\n",
      "\n",
      "CALML5 - KRT2 - CASP14:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "PRM2 - PRM1:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "RPS27 - RPS15A:\n"
     ]
    },
    {
     "data": {
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       "  <thead>\n",
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       "      <th></th>\n",
       "      <th>Adjusted P-value</th>\n",
       "      <th>Term</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0.009371</td>\n",
       "      <td>Formation of the ternary complex, and subsequently, the 43S complex Homo sapiens R-HSA-72695</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>0.006105</td>\n",
       "      <td>Ribosomal scanning and start codon recognition Homo sapiens R-HSA-72702</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>0.004070</td>\n",
       "      <td>Translation initiation complex formation Homo sapiens R-HSA-72649</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>0.003161</td>\n",
       "      <td>Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Homo sapiens R-HSA-72662</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>0.005334</td>\n",
       "      <td>Viral mRNA Translation Homo sapiens R-HSA-192823</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>5</th>\n",
       "      <td>0.004445</td>\n",
       "      <td>Peptide chain elongation Homo sapiens R-HSA-156902</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>0.004088</td>\n",
       "      <td>Selenocysteine synthesis Homo sapiens R-HSA-2408557</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7</th>\n",
       "      <td>0.003577</td>\n",
       "      <td>Eukaryotic Translation Termination Homo sapiens R-HSA-72764</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8</th>\n",
       "      <td>0.003329</td>\n",
       "      <td>Eukaryotic Translation Elongation Homo sapiens R-HSA-156842</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>9</th>\n",
       "      <td>0.002996</td>\n",
       "      <td>Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Homo sapiens R-HSA-975956</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>10</th>\n",
       "      <td>0.003171</td>\n",
       "      <td>Formation of a pool of free 40S subunits Homo sapiens R-HSA-72689</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>11</th>\n",
       "      <td>0.003548</td>\n",
       "      <td>Nonsense-Mediated Decay (NMD) Homo sapiens R-HSA-927802</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>12</th>\n",
       "      <td>0.003275</td>\n",
       "      <td>Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Homo sapiens R-HSA-975957</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13</th>\n",
       "      <td>0.003041</td>\n",
       "      <td>L13a-mediated translational silencing of Ceruloplasmin expression Homo sapiens R-HSA-156827</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>14</th>\n",
       "      <td>0.002838</td>\n",
       "      <td>3' -UTR-mediated translational regulation Homo sapiens R-HSA-157279</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>15</th>\n",
       "      <td>0.002711</td>\n",
       "      <td>SRP-dependent cotranslational protein targeting to membrane Homo sapiens R-HSA-1799339</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>16</th>\n",
       "      <td>0.002552</td>\n",
       "      <td>GTP hydrolysis and joining of the 60S ribosomal subunit Homo sapiens R-HSA-72706</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>17</th>\n",
       "      <td>0.002595</td>\n",
       "      <td>Selenoamino acid metabolism Homo sapiens R-HSA-2408522</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>18</th>\n",
       "      <td>0.002593</td>\n",
       "      <td>Cap-dependent Translation Initiation Homo sapiens R-HSA-72737</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>19</th>\n",
       "      <td>0.002464</td>\n",
       "      <td>Eukaryotic Translation Initiation Homo sapiens R-HSA-72613</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>20</th>\n",
       "      <td>0.002961</td>\n",
       "      <td>Influenza Viral RNA Transcription and Replication Homo sapiens R-HSA-168273</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>21</th>\n",
       "      <td>0.003192</td>\n",
       "      <td>Influenza Life Cycle Homo sapiens R-HSA-168255</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>22</th>\n",
       "      <td>0.003569</td>\n",
       "      <td>Influenza Infection Homo sapiens R-HSA-168254</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>23</th>\n",
       "      <td>0.003610</td>\n",
       "      <td>Translation Homo sapiens R-HSA-72766</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>24</th>\n",
       "      <td>0.004191</td>\n",
       "      <td>Major pathway of rRNA processing in the nucleolus Homo sapiens R-HSA-6791226</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>25</th>\n",
       "      <td>0.004740</td>\n",
       "      <td>rRNA processing Homo sapiens R-HSA-72312</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>26</th>\n",
       "      <td>0.015851</td>\n",
       "      <td>Metabolism of amino acids and derivatives Homo sapiens R-HSA-71291</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>27</th>\n",
       "      <td>0.016496</td>\n",
       "      <td>Infectious disease Homo sapiens R-HSA-5663205</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "    Adjusted P-value                                                                                                                             Term\n",
       "0           0.009371                                     Formation of the ternary complex, and subsequently, the 43S complex Homo sapiens R-HSA-72695\n",
       "1           0.006105                                                          Ribosomal scanning and start codon recognition Homo sapiens R-HSA-72702\n",
       "2           0.004070                                                                Translation initiation complex formation Homo sapiens R-HSA-72649\n",
       "3           0.003161  Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Homo sapiens R-HSA-72662\n",
       "4           0.005334                                                                                 Viral mRNA Translation Homo sapiens R-HSA-192823\n",
       "5           0.004445                                                                               Peptide chain elongation Homo sapiens R-HSA-156902\n",
       "6           0.004088                                                                              Selenocysteine synthesis Homo sapiens R-HSA-2408557\n",
       "7           0.003577                                                                      Eukaryotic Translation Termination Homo sapiens R-HSA-72764\n",
       "8           0.003329                                                                      Eukaryotic Translation Elongation Homo sapiens R-HSA-156842\n",
       "9           0.002996                           Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Homo sapiens R-HSA-975956\n",
       "10          0.003171                                                                Formation of a pool of free 40S subunits Homo sapiens R-HSA-72689\n",
       "11          0.003548                                                                          Nonsense-Mediated Decay (NMD) Homo sapiens R-HSA-927802\n",
       "12          0.003275                              Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Homo sapiens R-HSA-975957\n",
       "13          0.003041                                      L13a-mediated translational silencing of Ceruloplasmin expression Homo sapiens R-HSA-156827\n",
       "14          0.002838                                                              3' -UTR-mediated translational regulation Homo sapiens R-HSA-157279\n",
       "15          0.002711                                           SRP-dependent cotranslational protein targeting to membrane Homo sapiens R-HSA-1799339\n",
       "16          0.002552                                                 GTP hydrolysis and joining of the 60S ribosomal subunit Homo sapiens R-HSA-72706\n",
       "17          0.002595                                                                           Selenoamino acid metabolism Homo sapiens R-HSA-2408522\n",
       "18          0.002593                                                                    Cap-dependent Translation Initiation Homo sapiens R-HSA-72737\n",
       "19          0.002464                                                                       Eukaryotic Translation Initiation Homo sapiens R-HSA-72613\n",
       "20          0.002961                                                      Influenza Viral RNA Transcription and Replication Homo sapiens R-HSA-168273\n",
       "21          0.003192                                                                                   Influenza Life Cycle Homo sapiens R-HSA-168255\n",
       "22          0.003569                                                                                    Influenza Infection Homo sapiens R-HSA-168254\n",
       "23          0.003610                                                                                             Translation Homo sapiens R-HSA-72766\n",
       "24          0.004191                                                     Major pathway of rRNA processing in the nucleolus Homo sapiens R-HSA-6791226\n",
       "25          0.004740                                                                                         rRNA processing Homo sapiens R-HSA-72312\n",
       "26          0.015851                                                               Metabolism of amino acids and derivatives Homo sapiens R-HSA-71291\n",
       "27          0.016496                                                                                    Infectious disease Homo sapiens R-HSA-5663205"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\n",
      "\n",
      "PGC - LIPF:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "TMEM160 - C4orf48:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "S100A9 - S100A8:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "HBD - HBB - HBA1 - HBA2:\n"
     ]
    },
    {
     "data": {
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       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>Adjusted P-value</th>\n",
       "      <th>Term</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0.001285</td>\n",
       "      <td>Erythrocytes take up oxygen and release carbon dioxide Homo sapiens R-HSA-1247673</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>0.001514</td>\n",
       "      <td>Erythrocytes take up carbon dioxide and release oxygen Homo sapiens R-HSA-1237044</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>0.001009</td>\n",
       "      <td>O2/CO2 exchange in erythrocytes Homo sapiens R-HSA-1480926</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>0.011842</td>\n",
       "      <td>Scavenging of heme from plasma Homo sapiens R-HSA-2168880</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>0.024676</td>\n",
       "      <td>Binding and Uptake of Ligands by Scavenger Receptors Homo sapiens R-HSA-2173782</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "   Adjusted P-value                                                                               Term\n",
       "0          0.001285  Erythrocytes take up oxygen and release carbon dioxide Homo sapiens R-HSA-1247673\n",
       "1          0.001514  Erythrocytes take up carbon dioxide and release oxygen Homo sapiens R-HSA-1237044\n",
       "2          0.001009                         O2/CO2 exchange in erythrocytes Homo sapiens R-HSA-1480926\n",
       "3          0.011842                          Scavenging of heme from plasma Homo sapiens R-HSA-2168880\n",
       "4          0.024676    Binding and Uptake of Ligands by Scavenger Receptors Homo sapiens R-HSA-2173782"
      ]
     },
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    },
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     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\n",
      "\n",
      "FGA - FGB:\n"
     ]
    },
    {
     "data": {
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       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>Adjusted P-value</th>\n",
       "      <th>Term</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0.000803</td>\n",
       "      <td>GRB2:SOS provides linkage to MAPK signaling for Integrins Homo sapiens R-HSA-354194</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>0.000402</td>\n",
       "      <td>p130Cas linkage to MAPK signaling for integrins Homo sapiens R-HSA-372708</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>0.000589</td>\n",
       "      <td>Common Pathway of Fibrin Clot Formation Homo sapiens R-HSA-140875</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>0.000671</td>\n",
       "      <td>Integrin alphaIIb beta3 signaling Homo sapiens R-HSA-354192</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>0.001019</td>\n",
       "      <td>Platelet Aggregation (Plug Formation) Homo sapiens R-HSA-76009</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>65</th>\n",
       "      <td>0.015342</td>\n",
       "      <td>Axon guidance Homo sapiens R-HSA-422475</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>66</th>\n",
       "      <td>0.017364</td>\n",
       "      <td>Hemostasis Homo sapiens R-HSA-109582</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>67</th>\n",
       "      <td>0.021588</td>\n",
       "      <td>Cytokine Signaling in Immune system Homo sapiens R-HSA-1280215</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>68</th>\n",
       "      <td>0.034205</td>\n",
       "      <td>Developmental Biology Homo sapiens R-HSA-1266738</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>69</th>\n",
       "      <td>0.035543</td>\n",
       "      <td>Innate Immune System Homo sapiens R-HSA-168249</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>70 rows × 2 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "    Adjusted P-value                                                                                 Term\n",
       "0           0.000803  GRB2:SOS provides linkage to MAPK signaling for Integrins Homo sapiens R-HSA-354194\n",
       "1           0.000402            p130Cas linkage to MAPK signaling for integrins Homo sapiens R-HSA-372708\n",
       "2           0.000589                    Common Pathway of Fibrin Clot Formation Homo sapiens R-HSA-140875\n",
       "3           0.000671                          Integrin alphaIIb beta3 signaling Homo sapiens R-HSA-354192\n",
       "4           0.001019                       Platelet Aggregation (Plug Formation) Homo sapiens R-HSA-76009\n",
       "..               ...                                                                                  ...\n",
       "65          0.015342                                              Axon guidance Homo sapiens R-HSA-422475\n",
       "66          0.017364                                                 Hemostasis Homo sapiens R-HSA-109582\n",
       "67          0.021588                       Cytokine Signaling in Immune system Homo sapiens R-HSA-1280215\n",
       "68          0.034205                                     Developmental Biology Homo sapiens R-HSA-1266738\n",
       "69          0.035543                                       Innate Immune System Homo sapiens R-HSA-168249\n",
       "\n",
       "[70 rows x 2 columns]"
      ]
     },
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    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\n",
      "\n",
      "RPL36A - RPL26:\n"
     ]
    },
    {
     "data": {
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       "  <thead>\n",
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       "      <th></th>\n",
       "      <th>Adjusted P-value</th>\n",
       "      <th>Term</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0.026668</td>\n",
       "      <td>Viral mRNA Translation Homo sapiens R-HSA-192823</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>0.013334</td>\n",
       "      <td>Peptide chain elongation Homo sapiens R-HSA-156902</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>0.009539</td>\n",
       "      <td>Selenocysteine synthesis Homo sapiens R-HSA-2408557</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>0.007155</td>\n",
       "      <td>Eukaryotic Translation Termination Homo sapiens R-HSA-72764</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>0.005991</td>\n",
       "      <td>Eukaryotic Translation Elongation Homo sapiens R-HSA-156842</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>5</th>\n",
       "      <td>0.004993</td>\n",
       "      <td>Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Homo sapiens R-HSA-975956</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>0.004983</td>\n",
       "      <td>Formation of a pool of free 40S subunits Homo sapiens R-HSA-72689</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7</th>\n",
       "      <td>0.005322</td>\n",
       "      <td>Nonsense-Mediated Decay (NMD) Homo sapiens R-HSA-927802</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8</th>\n",
       "      <td>0.004730</td>\n",
       "      <td>Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Homo sapiens R-HSA-975957</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>9</th>\n",
       "      <td>0.004257</td>\n",
       "      <td>L13a-mediated translational silencing of Ceruloplasmin expression Homo sapiens R-HSA-156827</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>10</th>\n",
       "      <td>0.003870</td>\n",
       "      <td>3' -UTR-mediated translational regulation Homo sapiens R-HSA-157279</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>11</th>\n",
       "      <td>0.003615</td>\n",
       "      <td>SRP-dependent cotranslational protein targeting to membrane Homo sapiens R-HSA-1799339</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>12</th>\n",
       "      <td>0.003337</td>\n",
       "      <td>GTP hydrolysis and joining of the 60S ribosomal subunit Homo sapiens R-HSA-72706</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13</th>\n",
       "      <td>0.003336</td>\n",
       "      <td>Selenoamino acid metabolism Homo sapiens R-HSA-2408522</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>14</th>\n",
       "      <td>0.003285</td>\n",
       "      <td>Cap-dependent Translation Initiation Homo sapiens R-HSA-72737</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>15</th>\n",
       "      <td>0.003080</td>\n",
       "      <td>Eukaryotic Translation Initiation Homo sapiens R-HSA-72613</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>16</th>\n",
       "      <td>0.003658</td>\n",
       "      <td>Influenza Viral RNA Transcription and Replication Homo sapiens R-HSA-168273</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>17</th>\n",
       "      <td>0.003902</td>\n",
       "      <td>Influenza Life Cycle Homo sapiens R-HSA-168255</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>18</th>\n",
       "      <td>0.004321</td>\n",
       "      <td>Influenza Infection Homo sapiens R-HSA-168254</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>19</th>\n",
       "      <td>0.004332</td>\n",
       "      <td>Translation Homo sapiens R-HSA-72766</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>20</th>\n",
       "      <td>0.004989</td>\n",
       "      <td>Major pathway of rRNA processing in the nucleolus Homo sapiens R-HSA-6791226</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>21</th>\n",
       "      <td>0.005602</td>\n",
       "      <td>rRNA processing Homo sapiens R-HSA-72312</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>22</th>\n",
       "      <td>0.018608</td>\n",
       "      <td>Metabolism of amino acids and derivatives Homo sapiens R-HSA-71291</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>23</th>\n",
       "      <td>0.019246</td>\n",
       "      <td>Infectious disease Homo sapiens R-HSA-5663205</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "    Adjusted P-value                                                                                                    Term\n",
       "0           0.026668                                                        Viral mRNA Translation Homo sapiens R-HSA-192823\n",
       "1           0.013334                                                      Peptide chain elongation Homo sapiens R-HSA-156902\n",
       "2           0.009539                                                     Selenocysteine synthesis Homo sapiens R-HSA-2408557\n",
       "3           0.007155                                             Eukaryotic Translation Termination Homo sapiens R-HSA-72764\n",
       "4           0.005991                                             Eukaryotic Translation Elongation Homo sapiens R-HSA-156842\n",
       "5           0.004993  Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Homo sapiens R-HSA-975956\n",
       "6           0.004983                                       Formation of a pool of free 40S subunits Homo sapiens R-HSA-72689\n",
       "7           0.005322                                                 Nonsense-Mediated Decay (NMD) Homo sapiens R-HSA-927802\n",
       "8           0.004730     Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Homo sapiens R-HSA-975957\n",
       "9           0.004257             L13a-mediated translational silencing of Ceruloplasmin expression Homo sapiens R-HSA-156827\n",
       "10          0.003870                                     3' -UTR-mediated translational regulation Homo sapiens R-HSA-157279\n",
       "11          0.003615                  SRP-dependent cotranslational protein targeting to membrane Homo sapiens R-HSA-1799339\n",
       "12          0.003337                        GTP hydrolysis and joining of the 60S ribosomal subunit Homo sapiens R-HSA-72706\n",
       "13          0.003336                                                  Selenoamino acid metabolism Homo sapiens R-HSA-2408522\n",
       "14          0.003285                                           Cap-dependent Translation Initiation Homo sapiens R-HSA-72737\n",
       "15          0.003080                                              Eukaryotic Translation Initiation Homo sapiens R-HSA-72613\n",
       "16          0.003658                             Influenza Viral RNA Transcription and Replication Homo sapiens R-HSA-168273\n",
       "17          0.003902                                                          Influenza Life Cycle Homo sapiens R-HSA-168255\n",
       "18          0.004321                                                           Influenza Infection Homo sapiens R-HSA-168254\n",
       "19          0.004332                                                                    Translation Homo sapiens R-HSA-72766\n",
       "20          0.004989                            Major pathway of rRNA processing in the nucleolus Homo sapiens R-HSA-6791226\n",
       "21          0.005602                                                                rRNA processing Homo sapiens R-HSA-72312\n",
       "22          0.018608                                      Metabolism of amino acids and derivatives Homo sapiens R-HSA-71291\n",
       "23          0.019246                                                           Infectious disease Homo sapiens R-HSA-5663205"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\n",
      "\n",
      "SFTPB - SFTPA1:\n"
     ]
    },
    {
     "data": {
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       "<div>\n",
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       "\n",
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       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>Adjusted P-value</th>\n",
       "      <th>Term</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>0.000076</td>\n",
       "      <td>Defective ABCA3 causes pulmonary surfactant metabolism dysfunction type 3 (SMDP3) Homo sapiens R-HSA-5683678</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>0.000107</td>\n",
       "      <td>Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) Homo sapiens R-HSA-5688849</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>0.000071</td>\n",
       "      <td>Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) Homo sapiens R-HSA-5688890</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>0.000054</td>\n",
       "      <td>ABC transporter disorders Homo sapiens R-HSA-5619084</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>0.000069</td>\n",
       "      <td>Diseases associated with surfactant metabolism Homo sapiens R-HSA-5687613</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>5</th>\n",
       "      <td>0.000134</td>\n",
       "      <td>Disorders of transmembrane transporters Homo sapiens R-HSA-5619115</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>0.000444</td>\n",
       "      <td>Surfactant metabolism Homo sapiens R-HSA-5683826</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7</th>\n",
       "      <td>0.000947</td>\n",
       "      <td>Diseases of metabolism Homo sapiens R-HSA-5668914</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "   Adjusted P-value                                                                                                          Term\n",
       "0          0.000076  Defective ABCA3 causes pulmonary surfactant metabolism dysfunction type 3 (SMDP3) Homo sapiens R-HSA-5683678\n",
       "1          0.000107      Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) Homo sapiens R-HSA-5688849\n",
       "2          0.000071      Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) Homo sapiens R-HSA-5688890\n",
       "3          0.000054                                                          ABC transporter disorders Homo sapiens R-HSA-5619084\n",
       "4          0.000069                                     Diseases associated with surfactant metabolism Homo sapiens R-HSA-5687613\n",
       "5          0.000134                                            Disorders of transmembrane transporters Homo sapiens R-HSA-5619115\n",
       "6          0.000444                                                              Surfactant metabolism Homo sapiens R-HSA-5683826\n",
       "7          0.000947                                                             Diseases of metabolism Homo sapiens R-HSA-5668914"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\n",
      "\n",
      "ZFX - KDM5C:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n"
     ]
    }
   ],
   "source": [
    "brain_wholeblood = [\n",
    "    ['RPL38', 'RPL13A', 'RPL37A', 'RPL27A'],\n",
    "    ['REG1A', 'SYCN', 'PLA2G1B', 'CELA2A', 'CTRB2', 'CTRB1', 'CELA3B', 'CELA3A', 'CPB1', 'PNLIP', 'PRSS1', 'REG1B', 'CPA1', 'GP2', 'PNLIPRP1', 'CLPS'],\n",
    "    ['PWP2', 'C21orf33'],\n",
    "    ['CKM', 'MYL2', 'ACTA1', 'MYH2', 'TNNI1', 'MB', 'MYL1'],\n",
    "    ['C1QB', 'C1QA', 'C1QC'],\n",
    "    ['KRT13', 'KRT4', 'CRNN', 'SPRR3'],\n",
    "    ['RPS3A', 'RPL31', 'RPL32', 'RPL23', 'RPS29', 'RPL30', 'RPS21'],\n",
    "    ['CALML5', 'KRT2', 'CASP14'],\n",
    "    ['PRM2', 'PRM1'],\n",
    "    ['RPS27', 'RPS15A'],\n",
    "    ['PGC', 'LIPF'],\n",
    "    ['TMEM160', 'C4orf48'],\n",
    "    ['S100A9', 'S100A8'],\n",
    "    ['HBD', 'HBB', 'HBA1', 'HBA2'],\n",
    "    ['FGA', 'FGB'],\n",
    "    ['RPL36A', 'RPL26'],\n",
    "    ['SFTPB', 'SFTPA1'],\n",
    "    ['ZFX', 'KDM5C']\n",
    "]\n",
    "\n",
    "print_lists_to_enrich(brain_wholeblood)"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Non-Brain Tissues"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 4,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "HBA1 - HBA2:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "PWP2 - C21orf33:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "TMEM176B - TMEM176A:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n",
      "PRM2 - PRM1:\n",
      "No enrichment below adjusted p-value $< 0.05$.\n",
      "\n",
      "\n"
     ]
    }
   ],
   "source": [
    "non_brain = [\n",
    "    ['HBA1', 'HBA2'],\n",
    "    ['PWP2', 'C21orf33'],\n",
    "    ['TMEM176B', 'TMEM176A'],\n",
    "    ['PRM2', 'PRM1']\n",
    "]\n",
    "\n",
    "print_lists_to_enrich(non_brain)"
   ]
  }
 ],
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