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<!DOCTYPE html>
<html lang="en">
<head>
<title>Sensoryomics</title>
<meta charset="utf-8">
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<section class="picture-display">
<div class="container px-4 py-5 features">
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<h2 class="featurette-heading">Mapping Human Nociceptors
</h2>
<p class="lead text-justify">Nociceptors are specialized sensory neurons that detect damaging or potentially
damaging stimuli and are found in the dorsal root ganglia (DRG) and trigeminal ganglia. These neurons are
critical for the generation of neuronal signals that ultimately create the perception of pain. We sought to
generate information for human nociceptors with the goal of identifying transcriptomic signatures of
nociceptors, identifying species differences and potential drug targets.</p>
<p class="text-justify" style=”line-height: 100%” <em <font size=3><b>Citation:</b> Diana Tavares-Ferreira,
Stephanie Shiers, Pradipta R Ray, Andi Wangzhou, Vivekanand Jeevakumar, Ishwarya Sankaranarayanan, Anna M
Cervantes, Jeffrey C Reese, Alexander Chamessian, Bryan A Copits, Patrick M Dougherty, Robert W Gereau 4th,
Michael D Burton, Gregory Dussor, Theodore J Price, Spatial transcriptomics of dorsal root ganglia
identifies molecular signatures of human nociceptors.Sci. Transl. Med.14,eabj8186(2022).
DOI:10.1126/scitranslmed.abj8186 <a href=https://pubmed.ncbi.nlm.nih.gov/35171654 />(Article link)</a>
</font></em></p>
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<img src="style/NPP.webp" class="image-sm-hidden" alt="pic 1" width="100%" height="470" style="border: none;">
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<div class="col-md-7" style=" padding-left: 15px; padding-right: 15px;">
<h2 class="featurette-heading"> Thoracic vertebrectomy pain DRG bulk RNA sequencing
</h2>
<p class="lead text-justify">Neuropathic pain is a leading cause of high-impact pain, is often disabling and
is poorly managed by current therapeutics. Here we focused on a unique group of neuropathic pain patients
undergoing thoracic vertebrectomy where the dorsal root ganglia is removed as part of the surgery.
Our findings give direct support for sex differences in underlying mechanisms of neuropathic pain in patient
populations.</p>
<p class="text-justify" style=”line-height: 100%” <em <font size=3><b>Citation:</b> Pradipta R Ray, Stephanie
Shiers, James P Caruso, Diana Tavares-Ferreira, Ishwarya Sankaranarayanan, Megan L Uhelski, Yan Li, Robert Y
North, Claudio Tatsui, Gregory Dussor, Michael D Burton, Patrick M Dougherty, Theodore J Price, RNA
profiling of human dorsal root ganglia reveals sex differences in mechanisms promoting neuropathic pain,
Brain, Volume 146, Issue 2, February 2023, Pages 749–766 <a
href=https://doi.org/10.1093/brain/awac266>(Journal article link)</a></font></em></p>
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<h2 class="featurette-heading"> Human and Mouse DRG Transcriptome Profiles
</h2>
<p class="lead text-justify">We present our work as an online, searchable repository creating a valuable
resource for the community. Our analyses provide insight into DRG biology for guiding development of novel
therapeutics and a blueprint for cross-species transcriptomic analyses.</p>
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<a href=https://paincenter.utdallas.edu/sensoryomics/ style="color:white">Explore Data</a>
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<h2 class="featurette-heading"> Legacy Site
</h2>
<p class="lead">We are currently working on migrating all our datasets to one inclusive R shiny site. If you
would like to view the original legacy site you can visit the below site.</p>
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<a href=https://apps.utdallas.edu/bbs/painneurosciencelab/sensoryomics/ style="color:white">Legacy Site</a>
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