diff --git a/gvsbuild/patches/gobject-introspection/002-remove-distutils-msvccompiler.patch b/gvsbuild/patches/gobject-introspection/002-remove-distutils-msvccompiler.patch
new file mode 100644
index 000000000..922512c4f
--- /dev/null
+++ b/gvsbuild/patches/gobject-introspection/002-remove-distutils-msvccompiler.patch
@@ -0,0 +1,81 @@
+diff --git a/giscanner/ccompiler.py b/giscanner/ccompiler.py
+index d0ed70a3c4a1a6b7f9029827e87920cb34841334..9a732cd5ee92a99e6c60d76dafd5788a933ad383 100644
+--- a/giscanner/ccompiler.py
++++ b/giscanner/ccompiler.py
+@@ -26,7 +26,6 @@ import tempfile
+ import sys
+ import distutils
+
+-from distutils.msvccompiler import MSVCCompiler
+ from distutils.unixccompiler import UnixCCompiler
+ from distutils.cygwinccompiler import Mingw32CCompiler
+ from distutils.sysconfig import get_config_vars
+@@ -167,7 +166,7 @@ class CCompiler(object):
+         # Now, create the distutils ccompiler instance based on the info we have.
+         if compiler_name == 'msvc':
+             # For MSVC, we need to create a instance of a subclass of distutil's
+-            # MSVC9Compiler class, as it does not provide a preprocess()
++            # MSVCCompiler class, as it does not provide a preprocess()
+             # implementation
+             from . import msvccompiler
+             self.compiler = msvccompiler.get_msvc_compiler()
+@@ -460,7 +459,7 @@ class CCompiler(object):
+             return self.compiler.linker_exe
+
+     def check_is_msvc(self):
+-        return isinstance(self.compiler, MSVCCompiler)
++        return self.compiler.compiler_type == "msvc"
+
+     # Private APIs
+     def _set_cpp_options(self, options):
+@@ -486,7 +485,7 @@ class CCompiler(object):
+                     # macros for compiling using distutils
+                     # get dropped for MSVC builds, so
+                     # escape the escape character.
+-                    if isinstance(self.compiler, MSVCCompiler):
++                    if self.check_is_msvc():
+                         macro_value = macro_value.replace('\"', '\\\"')
+                 macros.append((macro_name, macro_value))
+             elif option.startswith('-U'):
+diff --git a/giscanner/msvccompiler.py b/giscanner/msvccompiler.py
+index 0a543982007d0c813575b16c94709f5c342b4372..e333a80f548e17df8ca158627164ac6fb841cd99 100644
+--- a/giscanner/msvccompiler.py
++++ b/giscanner/msvccompiler.py
+@@ -19,30 +19,30 @@
+ #
+
+ import os
+-import distutils
++from typing import Type
+
+ from distutils.errors import DistutilsExecError, CompileError
+-from distutils.ccompiler import CCompiler, gen_preprocess_options
++from distutils.ccompiler import CCompiler, gen_preprocess_options, new_compiler
+ from distutils.dep_util import newer
+
+ # Distutil's MSVCCompiler does not provide a preprocess()
+ # Implementation, so do our own here.
+
+
++DistutilsMSVCCompiler: Type = type(new_compiler(compiler="msvc"))
++
++
+ def get_msvc_compiler():
+     return MSVCCompiler()
+
+
+-class MSVCCompiler(distutils.msvccompiler.MSVCCompiler):
++class MSVCCompiler(DistutilsMSVCCompiler):
+
+     def __init__(self, verbose=0, dry_run=0, force=0):
+-        super(distutils.msvccompiler.MSVCCompiler, self).__init__()
++        super(DistutilsMSVCCompiler, self).__init__()
+         CCompiler.__init__(self, verbose, dry_run, force)
+         self.__paths = []
+         self.__arch = None  # deprecated name
+-        if os.name == 'nt':
+-            if isinstance(self, distutils.msvc9compiler.MSVCCompiler):
+-                self.__version = distutils.msvc9compiler.VERSION
+         self.initialized = False
+         self.preprocess_options = None
+         if self.check_is_clang_cl():
diff --git a/gvsbuild/projects/gobject_introspection.py b/gvsbuild/projects/gobject_introspection.py
index 249032e24..9042685ce 100644
--- a/gvsbuild/projects/gobject_introspection.py
+++ b/gvsbuild/projects/gobject_introspection.py
@@ -43,6 +43,8 @@ def __init__(self):
             patches=[
                 # https://gitlab.gnome.org/GNOME/gobject-introspection/-/issues/427
                 "001-incorrect-giscanner-path.patch",
+                # https://gitlab.gnome.org/GNOME/gobject-introspection/-/merge_requests/490
+                "002-remove-distutils-msvccompiler.patch",
             ],
         )