-
Notifications
You must be signed in to change notification settings - Fork 0
/
halides_selection_server.py
248 lines (221 loc) · 14.4 KB
/
halides_selection_server.py
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
from halides_selection import *
import umap
from sklearnex import patch_sklearn
patch_sklearn()
# def compute_umap_with_distmatrix_and_save(db_filepath, distmatrix_cache_filename='auto', output_filename='auto',
# fp_colname = 'fp_ECFP6_bv', memmap_mode=None, umap_params=None,
# limit_rows=None, change_dtypes_to_str=True):
# # extract the filepath without extension
# db_filepath_without_extension = db_filepath.split('.')[0]
# if distmatrix_cache_filename == 'auto':
# distmatrix_cache_filename = db_filepath_without_extension + '_distance_matrix.npy'
# if umap_params is None: # use default parameters
# umap_params = {'n_neighbors':15, 'n_components':2, 'metric':'precomputed'}
# if output_filename == 'auto':
# output_filename = db_filepath_without_extension + '_tsne.hdf'
# df = pd.read_pickle(db_filepath)
# if limit_rows is not None:
# df = df.iloc[:limit_rows]
# dist_matrix = distance_matrix(df, cache_filename=distmatrix_cache_filename, fp_colname=fp_colname,
# memmap_mode=memmap_mode)
# if limit_rows is not None:
# dist_matrix = dist_matrix[:limit_rows, :limit_rows]
# logging.info(f'Loaded distance matrix from {distmatrix_cache_filename}')
#
#
# reducer = umap.UMAP(**umap_params)
# z = reducer.fit_transform(dist_matrix)
# df["x"] = z[:, 0]
# df["y"] = z[:, 1]
#
# # drop these columns because they are objects and cannot be saved to hdf without pickle, but pickle
# # has compatibitily issues betweeb versions of python/pickle/pandas
# if 'fp_ECFP6_bv' in df.columns:
# df = df.drop(columns=['fp_ECFP6_bv', 'fp_ECFP6'])
# if 'fp_MAP4_bv' in df.columns:
# df = df.drop(columns=['fp_MAP4_bv', 'fp_MAP4'])
# # change drypes to string
# if change_dtypes_to_str:
# df['smiles'] = df['smiles'].astype(str)
# df['id'] = df['id'].astype(str)
# df['class'] = df['class'].astype(str)
# pickle.HIGHEST_PROTOCOL = 4
# df.to_hdf(output_filename, 'df')
#
# logging.info(f'Saved umap embedding to {output_filename}')
#### OPERATIONS AFTER CUSTOM POLYKETIDES ADDED MANUALLY BY ANTONIO
######### FOR ALL DNP
######### nondecimated_dataset
# ECFP 4
# df = pd.read_pickle('data/DNP_FULL_2016_with_polyketides_fingerprints_fixed.pickle')
# distance_matrix(df, cache_filename=f'data/DNP_FULL_2016_with_polyketides_fingerprints_fixed_distance_matrix.npy',
# force_recalculate=True, algo='loop', fp_colname='fp_ECFP6_bv')
# MAP4
# compute_fingerprints_for_df(db_filepath='data/DNP_FULL_2016_with_polyketides_fingerprints_fixed2.pickle',
# force_recalculate=True, fp_colname='fp_MAP4', N_PROC=70)
# df = pd.read_pickle('data/DNP_FULL_2016_with_polyketides_fingerprints_fixed2_map4fingerprints.pickle')
# distmat = distance_matrix(df, cache_filename=f'data/DNP_FULL_2016_with_polyketides_fingerprints_fixed_map4fingerprints_distance_matrix.npy',
# force_recalculate=True, algo='loop', fp_colname='fp_MAP4_bv')
# print(distmat.shape)
# tsne_params = {'n_components': 2, 'verbose': 2, 'random_state': 137,
# 'metric': 'precomputed',
# 'early_exaggeration': 1, 'perplexity': 300, 'init': 'random',
# 'n_iter': 5000, 'learning_rate': 70000,
# 'n_iter_without_progress': 10000, 'method': 'barnes_hut',
# 'n_jobs': 1}
#
# for perplexity in [3000]:
# for learning_rate in [70000]:
# logging.info(f'learning_rate={learning_rate}, perplexity={perplexity}')
# db_filepath = 'data/DNP_FULL_2016_with_polyketides_fingerprints_fixed2_map4fingerprints.pickle'
# tsne_params['learning_rate'] = int(round(learning_rate / 283 * 300))
# tsne_params['perplexity'] = int(round(perplexity / 283 * 300))
# filepath_without_extension = db_filepath.split('.')[0]
# distmatrix_cache_filename = f'data/DNP_FULL_2016_with_polyketides_fingerprints_fixed_map4fingerprints_distance_matrix.npy'
# compute_tsne_with_distmatrix_and_save(db_filepath=db_filepath,
# distmatrix_cache_filename=distmatrix_cache_filename,
# output_filename=f'{filepath_without_extension}_tsne_px{tsne_params["perplexity"]}_lr{tsne_params["learning_rate"]}.hdf',
# memmap_mode='r', tsne_params=tsne_params)
# ################## UMAP WITH MAP4
# db_filepath = 'data/DNP_FULL_2016_with_polyketides_fingerprints_fixed2_map4fingerprints.pickle'
# umap_params = {'n_neighbors': 1000, 'n_components': 2, 'metric': 'precomputed', 'verbose': True, 'min_dist': 0.1,}
#
# for n_neighbours in [1000]:
# for min_dist in [0.01, 0.05, 0.2, 0.5, 1]:
# umap_params['n_neighbors'] = n_neighbours
# umap_params['min_dist'] = min_dist
# logging.info(f'UMAP with n_neighbors={n_neighbours}')
# filepath_without_extension = db_filepath.split('.')[0]
# distmatrix_cache_filename = f'data/DNP_FULL_2016_with_polyketides_fingerprints_fixed_map4fingerprints_distance_matrix.npy'
# compute_umap_with_distmatrix_and_save(db_filepath=db_filepath,
# distmatrix_cache_filename=distmatrix_cache_filename,
# output_filename=f'{filepath_without_extension}_umap_nn{umap_params["n_neighbors"]}_md{umap_params["min_dist"]}.hdf',
# memmap_mode='r', umap_params=umap_params,
# change_dtypes_to_str=False)
# df = pd.read_pickle('data/DNP_FULL_2016_with_polyketides_fingerprints_len100k.pickle')
# distance_matrix(df, cache_filename=f'data/DNP_FULL_2016_with_polyketides_fingerprints_len100k_distance_matrix.npy',
# force_recalculate=True, algo='loop', fp_colname='fp_ECFP6_bv')
tsne_params = {'n_components': 2, 'verbose': 2, 'random_state': 138,
'metric': 'precomputed',
'early_exaggeration': 1, 'perplexity': 300, 'init': 'random',
'n_iter': 50000, 'learning_rate': 1000,
'n_iter_without_progress': 1000, 'method': 'barnes_hut',
'n_jobs': 1}
for perplexity in [100]:#[1000, 3000]:#, [1000, 3000, 10000, 30000, 100000, 300]:
for learning_rate in [70000]:
logging.info(f'learning_rate={learning_rate}, perplexity={perplexity}')
db_filepath = 'data/DNP_FULL_2016_with_polyketides_fingerprints_len100k.pickle'
tsne_params['learning_rate'] = int(round(learning_rate / 283 * 100))
tsne_params['perplexity'] = int(round(perplexity / 283 * 100))
filepath_without_extension = db_filepath.split('.')[0]
distmatrix_cache_filename = f'{filepath_without_extension}_distance_matrix.npy'
compute_tsne_with_distmatrix_and_save(db_filepath=db_filepath,
distmatrix_cache_filename=distmatrix_cache_filename,
output_filename=f'{filepath_without_extension}_tsne_px{tsne_params["perplexity"]}_lr{tsne_params["learning_rate"]}_'
f'{int(round(tsne_params["n_iter"]/1000))}kiter.hdf',
memmap_mode='r', tsne_params=tsne_params)
######### FOR ONLY PK
# df_filename = 'data/only_polyketides_fingerprints_len100k.pickle'
# df = pd.read_pickle(df_filename)
# distance_matrix(df, cache_filename=f'data/only_polyketides_fingerprints_len100k_distance_matrix.npy',
# force_recalculate=True, algo='loop', fp_colname='fp_ECFP6_bv')
#
# tsne_params = {'n_components': 2, 'verbose': 2, 'random_state': 137,
# 'metric': 'precomputed',
# 'early_exaggeration': 1, 'perplexity': 300, 'init': 'random',
# 'n_iter': 50000, 'learning_rate': 1000,
# 'n_iter_without_progress': 1000, 'method': 'barnes_hut',
# 'n_jobs': 1}
#
# for perplexity in [1000, 3000]:#, [1000, 3000, 10000, 30000, 100000, 300]:
# for learning_rate in [70000]:
# logging.info(f'learning_rate={learning_rate}, perplexity={perplexity}')
# db_filepath = df_filename
# tsne_params['learning_rate'] = int(round(learning_rate / 283 * 7.5))
# tsne_params['perplexity'] = int(round(perplexity / 283 * 7.5))
# filepath_without_extension = db_filepath.split('.')[0]
# distmatrix_cache_filename = f'{filepath_without_extension}_distance_matrix.npy'
# compute_tsne_with_distmatrix_and_save(db_filepath=db_filepath,
# distmatrix_cache_filename=distmatrix_cache_filename,
# output_filename=f'{filepath_without_extension}_tsne_px{tsne_params["perplexity"]}_lr{tsne_params["learning_rate"]}_'
# f'{int(round(tsne_params["n_iter"]/1000))}kiter.hdf',
# memmap_mode='r', tsne_params=tsne_params)
# ##### for only PK that have a-methyl-b-hydroxy
# df_filename = 'data/only_ab_polyketides_fingerprints.pickle'
# df = pd.read_pickle(df_filename)
# distance_matrix(df, cache_filename=f'data/only_ab_polyketides_fingerprints_distance_matrix.npy',
# force_recalculate=True, algo='loop', fp_colname='fp_ECFP6_bv')
#
# tsne_params = {'n_components': 2, 'verbose': 2, 'random_state': 137,
# 'metric': 'precomputed',
# 'early_exaggeration': 1, 'perplexity': 300, 'init': 'random',
# 'n_iter': 50000, 'learning_rate': 1000,
# 'n_iter_without_progress': 10000, 'method': 'barnes_hut',
# 'n_jobs': 1}
#
# for perplexity in [3000]:#, [1000, 3000, 10000, 30000, 100000, 300]:
# for learning_rate in [70000]:
# logging.info(f'learning_rate={learning_rate}, perplexity={perplexity}')
# db_filepath = df_filename
# tsne_params['learning_rate'] = int(round(learning_rate / 283 * 2.86))
# tsne_params['perplexity'] = int(round(perplexity / 283 * 2.86))
# filepath_without_extension = db_filepath.split('.')[0]
# distmatrix_cache_filename = f'{filepath_without_extension}_distance_matrix.npy'
# compute_tsne_with_distmatrix_and_save(db_filepath=db_filepath,
# distmatrix_cache_filename=distmatrix_cache_filename,
# output_filename=f'{filepath_without_extension}_tsne_px{tsne_params["perplexity"]}_lr{tsne_params["learning_rate"]}_'
# f'{int(round(tsne_params["n_iter"]/1000))}kiter.hdf',
# memmap_mode='r', tsne_params=tsne_params)
#### OPERATIONS BEFORE CUSTOM POLYKETIDES ADDED MANUALLY BY ANTONIO
###### ECFP6
# distance_matrix(df, cache_filename=f'data/DNP_FULL_2016_with_polyketides_map4fingerprints_distance_matrix.npy',
# force_recalculate=True, algo='two_loops', fp_colname='fp_MAP4_bv')
# df = pd.read_pickle('data/DNP_FULL_2016_with_polyketides_fingerprints_len100k.pickle')
# distance_matrix(df, cache_filename=f'data/DNP_FULL_2016_with_polyketides_fingerprints_len100k_distance_matrix.npy',
# force_recalculate=True, algo='loop')
#
# df = pd.read_pickle('data/DNP_FULL_2016_with_polyketides_fingerprints_len30k.pickle')
# distance_matrix(df, cache_filename=f'data/DNP_FULL_2016_with_polyketides_fingerprints_len30k_distance_matrix.npy',
# force_recalculate=True, algo='loop')
# tsne_params = {'n_components': 2, 'verbose': 2, 'random_state': 137,
# 'metric': 'precomputed',
# 'early_exaggeration': 1, 'perplexity': 300, 'init': 'random',
# 'n_iter': 50000, 'learning_rate': 1000,
# 'n_iter_without_progress': 10000, 'method': 'barnes_hut',
# 'n_jobs': 1}
# #
# # # # for perplexity in [3000, 30000]:
# # # # for perplexity in [10000, 100000]:
# for perplexity in [3000]:#, [1000, 3000, 10000, 30000, 100000, 300]:
# for learning_rate in [70000]:
# logging.info(f'learning_rate={learning_rate}, perplexity={perplexity}')
# if perplexity < 400:
# db_filepath = 'data/DNP_FULL_2016_with_polyketides_map4fingerprints.pickle'
# tsne_params['perplexity'] = perplexity
# tsne_params['learning_rate'] = learning_rate
# else:
# db_filepath = 'data/DNP_FULL_2016_with_polyketides_map4fingerprints_len100k.pickle'
# tsne_params['learning_rate'] = int(round(learning_rate / 283 * 100))
# tsne_params['perplexity'] = int(round(perplexity / 283 * 100))
# filepath_without_extension = db_filepath.split('.')[0]
# distmatrix_cache_filename = f'{filepath_without_extension}_distance_matrix.npy'
# compute_tsne_with_distmatrix_and_save(db_filepath=db_filepath,
# distmatrix_cache_filename=distmatrix_cache_filename,
# output_filename=f'{filepath_without_extension}_tsne_px{tsne_params["perplexity"]}_lr{tsne_params["learning_rate"]}.hdf',
# memmap_mode='r', tsne_params=tsne_params)
### MAP4
# compute_fingerprints_for_df(db_filepath='data/DNP_FULL_2016_with_polyketides.pickle',
# force_recalculate=True, fp_colname='fp_MAP4')
#
# df = pd.read_pickle('data/DNP_FULL_2016_with_polyketides_map4fingerprints.pickle')
# distmat = distance_matrix(df, cache_filename=f'data/DNP_FULL_2016_with_polyketides_map4fingerprints_distance_matrix.npy',
# force_recalculate=True, algo='loop', fp_colname='fp_MAP4_bv')
# print(distmat.shape)
# compute_fingerprints_for_df(db_filepath='data/DNP_FULL_2016_with_polyketides_fingerprints_len100k.pickle',
# force_recalculate=True, fp_colname='fp_MAP4',
# output_filepath='data/DNP_FULL_2016_with_polyketides_map4fingerprints_len100k.pickle')
#
# df = pd.read_pickle('data/DNP_FULL_2016_with_polyketides_map4fingerprints_len100k.pickle')
# distmat = distance_matrix(df, cache_filename=f'data/DNP_FULL_2016_with_polyketides_map4fingerprints_len100k_distance_matrix.npy',
# force_recalculate=True, algo='loop', fp_colname='fp_MAP4_bv')
# print(distmat.shape)