scbs 0.5.3 - DMR detection and overhauled matrix generation

This release comes with multiple new features and improvements:

• The new command scbs diff allows you to scan the whole genome for differentially methylated regions (DMRs) between two user-defined groups of cells. This works by sliding a window across the genome, performing a t-test for each window, and merging windows above a threshold. To control the false discovery rate, the same procedure is repeated on permutations of the data which are then used to calculate an adjusted p-value for each DMR.
• scbs matrix now reports the methylation matrix in a more convenient format (wide matrices instead of a huge long table).
• scbs matrix can now use multiple threads, which means it runs much faster when quantifying a large number of genomic intervals.
• scbs prepare now supports biscuit .BED files as input.