-
Notifications
You must be signed in to change notification settings - Fork 7
Commit
This commit does not belong to any branch on this repository, and may belong to a fork outside of the repository.
- Loading branch information
1 parent
6de3e2a
commit a3bbc57
Showing
9 changed files
with
4,305 additions
and
0 deletions.
There are no files selected for viewing
Large diffs are not rendered by default.
Oops, something went wrong.
This file contains bidirectional Unicode text that may be interpreted or compiled differently than what appears below. To review, open the file in an editor that reveals hidden Unicode characters.
Learn more about bidirectional Unicode characters
Original file line number | Diff line number | Diff line change |
---|---|---|
@@ -0,0 +1,52 @@ | ||
$PROBLEM Space in $INPUT - CYCLE =DROP | ||
|
||
;; One variable is dropped, BBW is a new name. | ||
;| Variables 15/20 |; | ||
$INPUT ROW ID NOMTIME TIME EVID CMT AMT DV FLAG STUDY | ||
BLQ CYCLE =DROP DOSE PART PROFDAY PROFTIME BBW eff0 | ||
|
||
$DATA ../data/xgxr1.csv IGNORE=@ IGNORE=(FLAG.NE.0) | ||
|
||
$SUBROUTINE ADVAN4 TRANS4 | ||
|
||
$PK | ||
KA=THETA(1)*EXP(ETA(1)) | ||
V2=THETA(2)*(BBW/75)*EXP(ETA(2)) | ||
CL=THETA(3)*EXP(ETA(3)) | ||
V3=THETA(4)*EXP(ETA(4)) | ||
Q=THETA(5)*EXP(ETA(5)) | ||
|
||
$ERROR | ||
IPRED=F | ||
IRES=DV-IPRED | ||
|
||
IF (IPRED.GT.1) THEN | ||
W = SQRT(IPRED**2*SIGMA(1,1)**2 + SIGMA(2,2)**2) | ||
ELSE | ||
W=1 | ||
ENDIF | ||
|
||
IWRES=IRES/W | ||
Y=F+F*ERR(1)+ERR(2) | ||
|
||
;-----------------------INITIAL ESTIMATES--------------------------------- | ||
$THETA (0,0.9) ; POPKA | ||
$THETA (0,4.2) ; POPCL | ||
$THETA (0,3.6) ; POPV2 | ||
$THETA (0,5.81) ; POPV3 | ||
$THETA (0,3.44) ; POPQ | ||
|
||
$OMEGA 0.1 | ||
$OMEGA 0.1 | ||
$OMEGA 0.1 | ||
$OMEGA 0 FIX | ||
$OMEGA 0 FIX | ||
|
||
$SIGMA .2 | ||
$SIGMA .2 | ||
|
||
$ESTIMATION METHOD=1 POSTHOC INTER MAXEVAL=9999 NSIG=2 SIGL=9 | ||
PRINT=10 NOABORT | ||
|
||
|
||
$TABLE ROW KA V2 CL V3 Q FILE=xgxr030_res.txt |
Large diffs are not rendered by default.
Oops, something went wrong.
Binary file not shown.
Binary file not shown.
Binary file not shown.
Binary file not shown.
Binary file not shown.
Binary file not shown.