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Diabetic Retinopathy Feature Extraction and Binary Diagnosis

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Segmentation of Blood Vessels, Optic Disc Localization, Detection of Exudates and Diabetic Retinopathy Diagnosis from Digital Fundus Images

Soham Basu, Sayantan Mukherjee, Ankit Bhattacharya, Anindya Sen

PWC

paper paper dataset dataset slides

Abstract: Diabetic Retinopathy (DR) is a complication of long-standing, unchecked diabetes and one of the leading causes of blindness in the world. This paper focuses on improved and robust methods to extract some of the features of DR, viz. Blood Vessels and Exudates. Blood vessels are segmented using multiple morphological and thresholding operations. For the segmentation of exudates, k-means clustering and contour detection on the original images are used. Extensive noise reduction is performed to remove false positives from the vessel segmentation algorithm's results. The localization of Optic Disc using k-means clustering and template matching is also performed. Lastly, this paper presents a Deep Convolutional Neural Network (DCNN) model with 14 Convolutional Layers and 2 Fully Connected Layers, for the automatic, binary diagnosis of DR. The vessel segmentation, optic disc localization and DCNN achieve accuracies of 95.93%, 98.77% and 75.73% respectively.


Proposed Methods

1. Blood Vessel Segmentation


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(a) Original Image, (b) Green channel component of (a), (c) CLAHE applied image, (d) Background estimated after Alternate Sequential Filtering, (e) Image (d) subtracted from (c) and CLAHE applied again, (f) Median blur and thresholding, (g) Final segmentation output.



Blood vessel segmentation algorithm


2. Optic Disc Localization


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(a) Original image, (b) Grayscale of (a), (c) Result of k-means clustering, (d) Generated Template, (e) Template Matching result (using NCCOEFF; notice the OD region has highest similarity), (f) Marking OD and its center, (g) Masking OD region.



Optic Disc Localization algorithm


3. Detection of Exudates


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(a) Original Image, (b) K-means clustering result, (c) Extracting the exudates from (b) and thresholding, (d) Logical OR of (c) and the images containing the smallest exudates, (e) Final segmentation result after OD masking.



Exudates Detection algorithm


4. Binary Diagnosis of Diabetic Retinopathy using a Deep Convolutional Neural Network

Proposed Neural Network architecture with the corresponding kernel/Filter sizes (k), number of feature maps (n) and strides (s) specified for each convolutional layer.


Results

1. Blood Vessel Segmentation

The DRIVE dataset was used for the evaluation of the proposed method.

The segmentation result for the best case (left) with ground truth (right)




2. Optic Disc Localization

The proposed method had an accuracy of 98.77% on the IDRiD Segmentation Dataset.

Optic Disc masked image (left) with the original image (right)



3. Detection of Exudates

We used the IDRiD Segmentation Dataset for testing our proposed exudates detection algorithm.


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(a), (b) Result of proposed exudates detection method (left) with original image (right).



4. Binary Diagnosis of DR using Deep CNN

The IDRiD Disease Grading dataset was used to train and evaluate the proposed network. It had an accuracy of 75.73% on a test set comprising 25% of the entire dataset.

DCNN training results with Training Accuracy, Test Accuracy and Training Loss




Cite our work

Basu, S., Mukherjee, S., Bhattacharya, A., Sen, A. (2021). Segmentation of Blood Vessels, Optic Disc Localization, Detection of Exudates, and Diabetic Retinopathy Diagnosis from Digital Fundus Images. In: Pan, I., Mukherjee, A., Piuri, V. (eds) Proceedings of Research and Applications in Artificial Intelligence. Advances in Intelligent Systems and Computing, vol 1355. Springer, Singapore. https://doi.org/10.1007/978-981-16-1543-6_16

Contact

For any queries, please contact: soham.basu07@gmail.com