CoV_PLE_concept_sets

covid PLE concept sets for Exposures

Currents sets to be developed

DMARDs

(Got it mostly from BCN studyathon)

Ts:

• Hydroxychloroquine (ingredient)
• Tocilizumab (ingredient)
• Sarilumab
• Baricitinib (ingredient)

Cs:

• Methotrexate (ingredient)
• Sulfasalazine (ingredient)

Anti-HIV antiviral therapies

Ts:

• Protease inhibitors [-navir]
• Protease inhibitors (Only HIV)
• Protease inhibitors - combination therapies
• Lopinavir (ingredient)
• Ritonavir (ingredient)

Cs:

• Integrase inhibitors (class) (includes

• raltegravir,

• elvitegravir,

• dolutegravir,

• bictegravir)

• Non-nucleoside reverse transcriptase inhibitors (class) (included

• efavirenz,

• nevirapine,

• delavirdine,

• etravirine,

• rilpivirine,

• doravirine)

Anti-Hepatitis C antiretroviral therapies

Ts:

• Hepatitis C virus NS3/4A protease inhibitors [–previr] (class)
• Asunaprevir (ingredient)
• Boceprevir (ingredient)
• Grazoprevir (ingredient)
• Glecaprevir (ingredient)
• Paritaprevir (ingredient)
• Simeprevir (ingredient)
• Telaprevir (ingredient)

Cs:

• Pegylated interferon (ingredient)
• Ribavirin (ingredient)

Drugs targeting the renin–angiotensin system

Ts:

• ACE inhibitors (class)
• ARBs (class)

Cs:

• Thiazides and thiazide-like diuretics (class)
• calcium channel blockers (class)

Other Drugs - We need to identify Comparators

• Eculizumab

• Oseltamivir

• Umifenovir (Arbidol)

• Favipiravir - Not yet in atlas demo

• Favilavir - Experimental

• APN01 - Experimental

• Umifenovir (ingredient)

• Remdesivir (ingredient) - Not yet in atlas demo

• Sildenafil citrate

• A lipoic acid

• Chloroquine phosphate

• Ebastine

• Interferon a

• Dyprimamole

• Bevacizumab

• Recombinant ace2

• Danoprevir

• Bromhexine hydrochloride

• Methyproednisolone

• Thalidomide

• Dihydroartemisinin/piperaquine