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 <title data-rh="true">Unraveling Anesthesia&#x27;s Effect on Brain Activity | DANDI</title><meta data-rh="true" name="viewport" content="width=device-width,initial-scale=1"><meta data-rh="true" name="twitter:card" content="summary_large_image"><meta data-rh="true" property="og:image" content="https://catalystneuro.github.io/dandi-docusaurus-example/img/docusaurus-social-card.jpg"><meta data-rh="true" name="twitter:image" content="https://catalystneuro.github.io/dandi-docusaurus-example/img/docusaurus-social-card.jpg"><meta data-rh="true" property="og:url" content="https://catalystneuro.github.io/dandi-docusaurus-example/blog/2024/09/09/data_reuse_000458"><meta data-rh="true" property="og:locale" content="en"><meta data-rh="true" name="docusaurus_locale" content="en"><meta data-rh="true" name="docusaurus_tag" content="default"><meta data-rh="true" name="docsearch:language" content="en"><meta data-rh="true" name="docsearch:docusaurus_tag" content="default"><meta data-rh="true" property="og:title" content="Unraveling Anesthesia&#x27;s Effect on Brain Activity | DANDI"><meta data-rh="true" name="description" content="Data Reuse Highlight: This blog entry is part of an ongoing series that showcases examples of data reuse and reanalysis using publicly available data on DANDI."><meta data-rh="true" property="og:description" content="Data Reuse Highlight: This blog entry is part of an ongoing series that showcases examples of data reuse and reanalysis using publicly available data on DANDI."><meta data-rh="true" property="og:type" content="article"><meta data-rh="true" property="article:published_time" content="2024-09-09T00:00:00.000Z"><meta data-rh="true" property="article:tag" content="reuse showcase"><link data-rh="true" rel="icon" href="/dandi-docusaurus-example/img/favicon.ico"><link data-rh="true" rel="canonical" href="https://catalystneuro.github.io/dandi-docusaurus-example/blog/2024/09/09/data_reuse_000458"><link data-rh="true" rel="alternate" href="https://catalystneuro.github.io/dandi-docusaurus-example/blog/2024/09/09/data_reuse_000458" hreflang="en"><link data-rh="true" rel="alternate" href="https://catalystneuro.github.io/dandi-docusaurus-example/blog/2024/09/09/data_reuse_000458" hreflang="x-default"><script data-rh="true" type="application/ld+json">{"@context":"https://schema.org","@type":"BlogPosting","@id":"https://catalystneuro.github.io/dandi-docusaurus-example/blog/2024/09/09/data_reuse_000458","mainEntityOfPage":"https://catalystneuro.github.io/dandi-docusaurus-example/blog/2024/09/09/data_reuse_000458","url":"https://catalystneuro.github.io/dandi-docusaurus-example/blog/2024/09/09/data_reuse_000458","headline":"Unraveling Anesthesia's Effect on Brain Activity","name":"Unraveling Anesthesia's Effect on Brain Activity","description":"Data Reuse Highlight: This blog entry is part of an ongoing series that showcases examples of data reuse and reanalysis using publicly available data on DANDI.","datePublished":"2024-09-09T00:00:00.000Z","author":{"@type":"Person","name":"Paul Adkisson"},"keywords":[],"isPartOf":{"@type":"Blog","@id":"https://catalystneuro.github.io/dandi-docusaurus-example/blog","name":"Blog"}}</script><link rel="alternate" type="application/rss+xml" href="/dandi-docusaurus-example/blog/rss.xml" title="DANDI RSS Feed">
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@@ -44,7 +44,7 @@ <h2 class="anchor anchorWithStickyNavbar_LWe7" id="a-new-perspective-zooming-in-
 By reanalyzing this data and manipulating a computational network model, they found that setting the E<sub>GABA<sub>A</sub>R</sub> parameter to the shunting regime (-60mV) reproduced spiking responses similar to those seen in awake mice (Figure 2 B&amp;F left).
 Conversely, setting it to the hyperpolarizing regime (-80mV) mimicked the responses seen in anesthetized mice (Figure 2 B&amp;F right).
 This data provides evidence for the hypothesized bidirectional relationship.</p>
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 <p><em><strong>Figure 2: Shunting inhibition promotes local network desynchronization and response flexibility.</strong>
 (A) High-density Neuropixels (NPXs) recordings were used to compare spiking activity in the same cortical neurons under awake and anesthetized conditions.
 (B) Example raster plots show the spiking activity of a population of neurons in somatosensory cortex (SS). Spiking activity is shown across three stimulation trials for each condition.

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