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Perl script to accumulate unique ports and targets from an input file and launch one nmap scan against all of them (@bonsaiviking)
perl -lanE'END{$,="\n";open$i,">ips";say$i keys%h;exec"nmap -iL ips -p".join(",",keys%p)}$h{$F[0]}=$p{$F[1]}=1' input.txt