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Welcome to the tabula-sapiens wiki!

Tabula Sapiens will be a benchmark, first-draft human cell atlas of two million cells from 25 organs of eight normal human subjects.

The goal of the project is to deliver annotated and analyzed high-quality transcriptomic data that will be integrated in the data coordination platform of the Human Cell Atlas. We will build directly on our unique skills, experience, and data infrastructure from Tabula Muris, Tabula Muris Senis and Tabula Microcebus to create a high-quality human reference dataset and portal at a 10-fold larger scale from these prior efforts.

One critical factor in the Tabula projects was our large collaborative network of PI’s with deep expertise at preparation of diverse organs, enabling all organs from a subject to be successfully processed within a single day. We have built the logistics and infrastructure capable of tracking hundreds of samples and thousands of 384-well plates from tissue through sample prep, library construction and on to sequencing and ultimately computational and expert cell annotation with tight quality control. We will supplement our network with human tissue expertise and use our experience to balance and assign cell types from each tissue compartment and optimally mix high-quality plate-seq data and high-volume droplet-based data to provide a broad and deep benchmark atlas.

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