1 Departamento de Física, Facultad de Ciencias, Universidad Nacional Autónoma de México
2 Laboratorio de Dinámica, Biofísica y Fisiología de Sistemas, Departamento de Matemáticas, Facultad de Ciencias, Universidad Nacional Autónoma de México
3 Department of Psychology, Wilfrid Laurier University
4 McKnight Brain Institute, University of Arizona
We developed a biophysical mathematical model to study age-related changes in ion channel expression and electrical activity in pyramidal cells (PCs) of the CA1 region of the hippocampus. This repository contains Python code embedded in a Jupyter notebook, simulation figures, and the manuscript files arising from this project. All of the content is openly licensed for reuse (see license file).
For more information on this project, please see our preprint:
McKiernan E.C., Herrera-Valdez, M.A. & Marrone, D.F.. A biophysical, minimal model to investigate age-related changes in CA1 pyramidal cell electrical activity. bioRxiv. https://doi.org/10.1101/2022.07.01.498486.
This work was supported by grants from the Natural Sciences and Engineering Research Council of Canada, as well as the Ontario Mental Health Foundation, awarded to DFM. This work was also supported by DGAPA-UNAM-PAPIIT IA209817 awarded to ECM; and by DGAPA-UNAM-PAPIIT IA208618, DGAPA-UNAM-PAPIIT IN228820, and DGAPA-UNAM-PAPIME PE114919 awarded to MAH-V.