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Merge pull request #29453 from geneontology/issue-29033a
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Added xrefs to ecdysteroid hydroxylase terms and made consistent. Fix…
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sjm41 authored Dec 17, 2024
2 parents 96d4268 + c490889 commit 469022b
Showing 1 changed file with 21 additions and 3 deletions.
24 changes: 21 additions & 3 deletions src/ontology/go-edit.obo
Original file line number Diff line number Diff line change
Expand Up @@ -212581,9 +212581,14 @@ is_a: GO:0140535 ! intracellular protein-containing complex
id: GO:0035302
name: ecdysteroid 25-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the hydroxylation of an ecdysteroid at carbon position 25. Ecdysteroids are a group of polyhydroxylated ketosteroids which initiate post-embryonic development, particularly metamorphosis, in insects and other arthropods." [ISBN:0198506732, PMID:15350618]
def: "Catalysis of the hydroxylation of an ecdysteroid at carbon position 25." [PMID:15350618]
comment: Note that in the ecdysteroidogenic pathway, this activity catalyzes the conversion of 2,22,25-trideoxyecdysone (3-beta,5-beta-ketodiol) to 2,22-dideoxyecdysone (3-beta,5-beta-ketotriol).
xref: MetaCyc:RXN-14677 {source="skos:narrowMatch"}
xref: MetaCyc:RXN-14680 {source="skos:narrowMatch"}
xref: RHEA:82347 {source="skos:narrowMatch"}
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/29033" xsd:anyURI

[Term]
id: GO:0035303
Expand Down Expand Up @@ -240432,15 +240437,28 @@ name: ecdysteroid 22-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the hydroxylation of an ecdysteroid at carbon position 22." [PMID:12177427]
comment: Note that in the ecdysteroidogenic pathway, this activity catalyzes the conversion of 2,22-dideoxyecdysone (ketotriol) to 2-deoxyecdysone.
synonym: "3-dehydro-2,22-dideoxyecdysone 22-hydroxylase activity" NARROW [EC:1.14.15.44]
xref: MetaCyc:RXN-14678 {source="skos:narrowMatch"}
xref: MetaCyc:RXN-14681 {source="skos:narrowMatch"}
xref: MetaCyc:RXN-24931 {source="skos:narrowMatch"}
xref: RHEA:82055 {source="skos:narrowMatch"}
xref: RHEA:83295 {source="skos:narrowMatch"}
xref: RHEA:83299 {source="skos:narrowMatch"}
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/29033" xsd:anyURI

[Term]
id: GO:0042768
name: ecdysteroid 2-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-deoxyecdysone + 2 reduced adrenodoxin + O2 + 2 H+ = ecdysone + 2 oxidized adrenodoxin + H2O." [MetaCyc:RXN-14679, PMID:12177427]
def: "Catalysis of the hydroxylation of an ecdysteroid at carbon position 2." [PMID:12177427]
comment: Note that in the ecdysteroidogenic pathway, this activity catalyzes the conversion of 2-deoxyecdysone to ecdysone. It can also catalyze the conversion of 2,22-dideoxyecdysone (ketotriol) to 22-deoxyecdysone.
xref: MetaCyc:RXN-14679
xref: MetaCyc:RXN-14679 {source="skos:narrowMatch"}
xref: MetaCyc:RXN-14682 {source="skos:narrowMatch"}
xref: MetaCyc:RXN-24932 {source="skos:narrowMatch"}
xref: RHEA:82351 {source="skos:narrowMatch"}
xref: RHEA:83255 {source="skos:narrowMatch"}
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/29033" xsd:anyURI
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