Merge pull request #29381 from geneontology/issue-28982

Updated NADH shuttle terms. Fixes #28982

src/ontology/go-edit.obo

@@ -58951,21 +58951,19 @@ replaced_by: GO:0022900
 
 [Term]
 id: GO:0006127
-name: glycerophosphate shuttle
+name: glycerol-3-phosphate shuttle
 namespace: biological_process
-def: "The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesize glycerol 3-phosphate in the cytosol; this compound is then transported into the mitochondria where it is converted to dihydroxyacetone phosphate (DHAP) using FAD; DHAP then returns to the cytosol to complete the cycle." [GOC:jl, GOC:mtg_electron_transport, ISBN:0716720094, PMID:16368075]
+def: "The process of transferring reducing equivalents from NADH in the cytosol into the mitochondria via glycerol-3-phosphate. Cytosolic glycerol-3-phosphate dehydrogenase uses NADH to convert dihydroxyacetone phosphate (DHAP) to glycerol-3-phosphate (G3P) in the cytosol; G3P then diffuses into the mitochondria where mitochondrial glycerol-3-phosphate dehydrogenase uses FAD to convert G3P back to DHAP; the electrons on the reduced FADH2 are then available for use in the electron transport chain, and DHAP returns to the cytosol to complete the cycle." [GOC:sjm, PMID:16368075]
+synonym: "glycerol phosphate shuttle" EXACT []
+synonym: "glycerophosphate shuttle" EXACT []
 xref: MetaCyc:PWY-6118
 intersection_of: GO:0008152 ! metabolic process
 intersection_of: has_part GO:0004368 ! glycerol-3-phosphate dehydrogenase (quinone) activity
 intersection_of: has_part GO:0141152 ! glycerol-3-phosphate dehydrogenase (NAD+) activity
-intersection_of: has_participant CHEBI:57597 ! sn-glycerol 3-phosphate(2-)
-intersection_of: has_participant CHEBI:57642 ! glycerone phosphate(2-)
-intersection_of: has_primary_input CHEBI:132124 ! 1,4-benzoquinones
 intersection_of: has_primary_input CHEBI:57945 ! NADH(2-)
-intersection_of: has_primary_output CHEBI:24646 ! hydroquinones
 intersection_of: has_primary_output CHEBI:57540 ! NAD(1-)
-relationship: part_of GO:0022904 ! respiratory electron transport chain
 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/26974" xsd:anyURI
+property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28982" xsd:anyURI
 
 [Term]
 id: GO:0006128
@@ -247735,13 +247733,19 @@ relationship: negatively_regulates GO:0006401 ! RNA catabolic process
 id: GO:0043490
 name: malate-aspartate shuttle
 namespace: biological_process
-def: "The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesize malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle." [GOC:jl, GOC:mtg_electron_transport, ISBN:0716743663]
+def: "The process of transferring reducing equivalents from NADH in the cytosol to the mitochondria via malate. Cytosolic aspartate aminotransferase converts aspartate to oxaloacetate, and cytosolic malate dehydrogenase uses NADH to convert oxaloacetate to malate in the cytosol; the malate-alpha-ketoglutarate carrier then transports the malate into the mitochondria where mitochondrial malate dehydrogenase uses NAD to convert malate back to oxaloacetate; the electrons on the reduced NADH are then available for use in the electron transport chain; mitochondrial aspartate aminotransferase converts oxaloacetate to aspartate, and the glutamate-aspartate carrier transports the aspartate back to the cytosol to complete the cycle." [GOC:sjm, PMID:16368075]
 synonym: "malate aspartate shuttle" EXACT []
 synonym: "malate/aspartate shuttle" EXACT []
 synonym: "malate:aspartate shuttle" EXACT []
+xref: MetaCyc:MALATE-ASPARTATE-SHUTTLE-PWY
 xref: Wikipedia:Malate-aspartate_shuttle
-is_a: GO:1990542 ! mitochondrial transmembrane transport
-relationship: part_of GO:0022904 ! respiratory electron transport chain
+intersection_of: GO:0008152 ! metabolic process
+intersection_of: has_part GO:0004069 ! L-aspartate:2-oxoglutarate aminotransferase activity
+intersection_of: has_part GO:0030060 ! L-malate dehydrogenase (NAD+) activity
+intersection_of: has_primary_input CHEBI:57945 ! NADH(2-)
+intersection_of: has_primary_output CHEBI:57540 ! NAD(1-)
+relationship: has_part GO:1990542 ! mitochondrial transmembrane transport
+property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28982" xsd:anyURI
 
 [Term]
 id: GO:0043491