feat(#638): show influence of active drugs

app/lib/common/models/drug/drug_inhibitors.dart

@@ -5,6 +5,10 @@
 
 // structure: gene symbol -> drug name -> overwriting lookupkey
 
+import 'package:dartx/dartx.dart';
+
+import 'drug.dart';
+
 const Map<String, Map<String, String>> drugInhibitors = {
   'CYP2D6': {
     // 0.0 is a lookupkey for a type of poor metabolizer
@@ -22,3 +26,15 @@ const Map<String, Map<String, String>> drugInhibitors = {
     'mirabegron': '1.0',
   }
 };
+
+
+bool isInhibitor(Drug drug) {
+  final influencingDrugs = drugInhibitors.keys.flatMap(
+    (gene) => drugInhibitors[gene]!.keys);
+  return influencingDrugs.contains(drug.name);
+}
+
+List<String> inhibitorFor(Drug drug) {
+  return drugInhibitors.keys.filter(
+    (gene) => drugInhibitors[gene]!.containsKey(drug.name)).toList();
+}

app/lib/common/pages/drug/widgets/annotation_cards/drug.dart

@@ -34,35 +34,48 @@ class DrugAnnotationCard extends StatelessWidget {
               ]
             ]),
             SizedBox(height: 4),
+            if (isInhibitor(drug)) ...[
+              SizedBox(height: 8),
+              Text(context.l10n.drugs_page_is_inhibitor(
+                drug.name,
+                inhibitorFor(drug).join(', '),
+              )),
+            ],
             Divider(color: PharMeTheme.borderColor),
             SizedBox(height: 4),
             SubHeader(context.l10n.drugs_page_header_active),
             CheckboxListTile(
               activeColor: PharMeTheme.primaryColor,
               title: Text(context.l10n.drugs_page_active),
               value: isActive,
-              onChanged: (newValue) => showCupertinoModalPopup(
-                context: context,
-                builder: (context) => CupertinoAlertDialog(
-                  title: Text(context.l10n.drugs_page_active_warn_header),
-                  content: Text(context.l10n.drugs_page_active_warn),
-                  actions: <CupertinoDialogAction>[
-                    CupertinoDialogAction(
-                      isDefaultAction: true,
-                      onPressed: () => Navigator.pop(context, 'Cancel'),
-                      child: Text(context.l10n.action_cancel),
+              onChanged: (newValue) => {
+                if (isInhibitor(drug)) {
+                  showCupertinoModalPopup(
+                    context: context,
+                    builder: (context) => CupertinoAlertDialog(
+                      title: Text(context.l10n.drugs_page_active_warn_header),
+                      content: Text(context.l10n.drugs_page_active_warn),
+                      actions: <CupertinoDialogAction>[
+                        CupertinoDialogAction(
+                          isDefaultAction: true,
+                          onPressed: () => Navigator.pop(context, 'Cancel'),
+                          child: Text(context.l10n.action_cancel),
+                        ),
+                        CupertinoDialogAction(
+                          isDestructiveAction: true,
+                          onPressed: () {
+                            Navigator.pop(context, 'OK');
+                            setActivity(newValue);
+                          },
+                          child: Text(context.l10n.action_continue),
+                        ),
+                      ],
                     ),
-                    CupertinoDialogAction(
-                      isDestructiveAction: true,
-                      onPressed: () {
-                        Navigator.pop(context, 'OK');
-                        setActivity(newValue);
-                      },
-                      child: Text(context.l10n.action_continue),
-                    ),
-                  ],
-                ),
-              ),
+                  )
+                } else {
+                  setActivity(newValue)
+                }
+              },
               controlAffinity: ListTileControlAffinity.leading,
             ),
           ],

app/lib/common/widgets/drug_list/builder.dart

@@ -4,6 +4,7 @@ List<Widget> buildDrugList(
   BuildContext context,
   DrugListState state, {
   String? noDrugsMessage,
+  bool? showInfluenceOnOtherDrugs,
 }) =>
     state.when(
       initial: () => [Container()],
@@ -13,6 +14,7 @@ List<Widget> buildDrugList(
         drugs,
         filter,
         noDrugsMessage: noDrugsMessage,
+        showInfluenceOnOtherDrugs: showInfluenceOnOtherDrugs,
       ),
       loading: () => [loadingIndicator()],
     );
@@ -22,6 +24,7 @@ List<Widget> _buildDrugCards(
   List<Drug> drugs,
   FilterState filter, {
   String? noDrugsMessage,
+  bool? showInfluenceOnOtherDrugs,
 }) {
   final filteredDrugs = filter.filter(drugs);
   if (filteredDrugs.isEmpty && noDrugsMessage != null) {
@@ -49,7 +52,10 @@ List<Widget> _buildDrugCards(
                   onTap: () => context.router
                       .push(DrugRoute(drug: drug))
                       .then((_) => context.read<DrugListCubit>().search()),
-                  drug: drug)),
+                  drug: drug,
+                  showInfluenceOnOtherDrugs: showInfluenceOnOtherDrugs ?? false,
+              )
+          ),
           SizedBox(height: 12)
         ]))
   ];
@@ -59,14 +65,20 @@ class DrugCard extends StatelessWidget {
   const DrugCard({
     required this.onTap,
     required this.drug,
+    required this.showInfluenceOnOtherDrugs
   });
 
   final VoidCallback onTap;
   final Drug drug;
+  final bool showInfluenceOnOtherDrugs;
 
   @override
   Widget build(BuildContext context) {
     final warningLevel = drug.userGuideline()?.annotations.warningLevel;
+    var drugName = drug.name.capitalize();
+    if (showInfluenceOnOtherDrugs) {
+      if (isInhibitor(drug)) drugName = '$drugName *';
+    }
 
     return RoundedCard(
       onTap: onTap,
@@ -84,7 +96,7 @@ class DrugCard extends StatelessWidget {
                   Icon(warningLevel?.icon ?? indeterminateIcon),
                   SizedBox(width: 4),
                   Text(
-                    drug.name.capitalize(),
+                    drugName,
                     style: PharMeTheme.textTheme.titleMedium!
                         .copyWith(fontWeight: FontWeight.bold),
                   ),

app/lib/l10n/app_en.arb

@@ -32,8 +32,23 @@
   "search_page_filter_yellow": "Yellow warning level",
   "search_page_filter_red": "Red warning level",
   "search_page_filter_gray": "No warning level",
+  "search_page_asterisk_explanation": "Drugs with an asterisk (*) influence results for other drugs",
 
   "drugs_page_disclaimer": "This assessment is ONLY based on your genetics. Important factors like weight, age and pre-existing conditions are not considered.",
+  "drugs_page_is_inhibitor": "Taking {drugName} influences your results for guidelines based on the following gene(s): {geneSymbols}",
+  "@drugs_page_is_inhibitor": {
+    "description": "Disclaimer for when the phenotype has been adjusted based on a current drug",
+    "placeholders": {
+        "drugName": {
+            "type": "String",
+            "example": "bupropion"
+        },
+        "geneSymbols": {
+          "type": "String",
+          "example": "CYP2D6, CYP2C19"
+        }
+    }
+  },
   "drugs_page_overwritten_phenotype": "adjusted based on you taking {drugName}",
   "@drugs_page_overwritten_phenotype": {
       "description": "Disclaimer for when the phenotype has been adjusted based on a current drug",
@@ -63,7 +78,7 @@
   "drugs_page_header_active": "Usage status",
   "drugs_page_active": "I am currently taking this drug.",
   "drugs_page_active_warn_header": "Are you sure you want to change the drug usage status?",
-  "drugs_page_active_warn": "This may adjust the guidelines you receive for other drugs.",
+  "drugs_page_active_warn": "This may influence the guidelines you receive for other drugs.",
   "drugs_page_header_guideline": "Clinical Guideline",
   "drugs_page_header_recommendation": "Recommendation",
   "drugs_page_no_guidelines_for_phenotype_implication": "More information is needed to comment on your DNA's influence on {drugName}.",
@@ -129,6 +144,7 @@
   "gene_page_affected_drugs": "Affected drugs",
   "gene_page_affected_drugs_tooltip": "The drugs listed here are affected by your variant of this gene.",
   "gene_page_no_affected_drugs": "Your variant of this gene has no known effect on any drug.",
+  "gene_page_inhibitor_drugs": "Guidelines based on this gene are influenced by taking the following drugs:",
 
   "pdf_pgx_report": "PGx Report",
   "pdf_heading_user_data": "User data",

app/lib/report/pages/gene.dart

@@ -31,21 +31,38 @@ class GenePage extends HookWidget {
                   ),
                   SizedBox(height: 12),
                   RoundedCard(
-                    child: Table(
-                      columnWidths: Map.from({
-                        0: IntrinsicColumnWidth(),
-                        1: IntrinsicColumnWidth(flex: 1),
-                      }),
+                    child: Column(
+                      crossAxisAlignment: CrossAxisAlignment.start,
                       children: [
-                        _buildRow(
-                            context.l10n.gene_page_genotype, phenotype.genotype,
-                            tooltip: context.l10n.gene_page_genotype_tooltip),
-                        _buildRow(context.l10n.gene_page_phenotype,
-                            UserData.phenotypeFor(phenotype.geneSymbol)!,
-                            tooltip: context.l10n.gene_page_phenotype_tooltip),
-                      ],
-                    ),
-                  ),
+                        Table(
+                          columnWidths: Map.from({
+                            0: IntrinsicColumnWidth(),
+                            1: IntrinsicColumnWidth(flex: 1),
+                          }),
+                          children: [
+                            _buildRow(
+                                context.l10n.gene_page_genotype,
+                                phenotype.genotype,
+                                tooltip: context.l10n.gene_page_genotype_tooltip
+                            ),
+                            _buildRow(context.l10n.gene_page_phenotype,
+                                UserData.phenotypeFor(phenotype.geneSymbol)!,
+                                tooltip:
+                                  context.l10n.gene_page_phenotype_tooltip
+                            ),
+                          ],
+                        ),
+                        if (drugInhibitors.containsKey(phenotype.geneSymbol))
+                          ...[
+                            SizedBox(height: PharMeTheme.smallSpace),
+                            Text(context.l10n.gene_page_inhibitor_drugs),
+                            SizedBox(height: PharMeTheme.smallSpace),
+                            Text(drugInhibitors[phenotype.geneSymbol]!.keys
+                              .join(', ')
+                            ),
+                          ],
+                    ],
+                  )),
                   SizedBox(height: 12),
                   SubHeader(context.l10n.gene_page_affected_drugs,
                       tooltip: context.l10n.gene_page_affected_drugs_tooltip),

app/lib/search/pages/search.dart

@@ -39,8 +39,19 @@ class SearchPage extends HookWidget {
               TooltipIcon(context.l10n.search_page_tooltip_search),
               buildFilter(context),
             ]),
-            body: buildDrugList(context, state,
-                noDrugsMessage: context.l10n.err_no_drugs),
+            body: [
+              Padding(
+                padding: EdgeInsets.symmetric(
+                  vertical: PharMeTheme.smallSpace,
+                  horizontal: PharMeTheme.mediumSpace
+                ),
+                child: Text(context.l10n.search_page_asterisk_explanation),
+              ),
+              ...buildDrugList(context, state,
+                noDrugsMessage: context.l10n.err_no_drugs,
+                showInfluenceOnOtherDrugs: true
+              ),
+            ],
           );
         }));
   }