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Minor documentation updates.
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daemontus committed Mar 22, 2024
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25 changes: 15 additions & 10 deletions balm/control.py
Original file line number Diff line number Diff line change
@@ -1,3 +1,8 @@
"""
This module implementes methods for permanent target control of Boolean networks
based on the structure of a succession diagram.
"""

from __future__ import annotations

from itertools import combinations, product
Expand Down Expand Up @@ -25,7 +30,7 @@ def __init__(
which returns a list of `Intervention` objects. Manipulating the
contents of these objects is only recommended for advanced use cases.
Typically, it is sufficient to print this object to see a human-readable
an explanation of how to interpret the intervention.
explanation of how to interpret the intervention.
Note that two interventions are considered to be equal if they act on the same succession with
equal controls applied to each subspace in the succession. Thus, two
Expand Down Expand Up @@ -142,12 +147,12 @@ def __str__(self):
)
if self.strategy == "internal":
return succession_string + " and then\n".join(
f"({' or '.join(map(str,motif_control))})"
f"({' or '.join(map(str, motif_control))})"
for motif_control in self.control
)
elif self.strategy == "all":
return succession_string + " temporarily, and then\n".join(
f"({' or '.join(map(str,motif_control))})"
f"({' or '.join(map(str, motif_control))})"
for motif_control in self.control
)
else:
Expand All @@ -174,7 +179,7 @@ def succession_control(
The target subspace.
strategy : str, optional
The searching strategy to use to look for driver nodes. Options are
'internal' (default), 'all'.
'internal' (default) and 'all'.
max_drivers_per_succession_node: int | None = None,
The maximum number of drivers that will be tested for a succession
diagram node. If `None`, then a number of drivers up to the size of the
Expand Down Expand Up @@ -382,11 +387,11 @@ def drivers_of_succession(
A list of sequentially nested trap spaces that specify the target.
strategy: str
The searching strategy to use to look for driver nodes. Options are
'internal' (default), 'all'.
'internal' (default) and 'all'.
max_drivers_per_succession_node: int | None = None,
The maximum number of drivers that will be tested for a succession
diagram node. If `None`, then a number of drivers up to the size of the
succession diagram node's stable motif will be tested
succession diagram node's stable motif will be tested.
forbidden_drivers: set[str] | None
A set of forbidden drivers that will not be overridden for control. If
`None`, then all nodes are candidates for control.
Expand Down Expand Up @@ -449,13 +454,13 @@ def find_drivers(
The trap space we want to find drivers for.
strategy: str
The searching strategy to use to look for driver nodes. Options are
'internal' (default), 'all'.
'internal' (default) and 'all'.
assume_fixed: dict[str,int] | None
A dictionary of fixed variables that should be assumed to be fixed.
max_drivers_per_succession_node: int | None = None,
The maximum number of drivers that will be tested for a succession
diagram node. If `None`, then a number of drivers up to the size of the
succession diagram node's stable motif will be tested
succession diagram node's stable motif will be tested.
forbidden_drivers: set[str] | None
A set of forbidden drivers that will not be overridden for control. If
`None`, then all nodes are candidates for control.
Expand Down Expand Up @@ -522,8 +527,8 @@ def controls_are_equal(a: ControlOverrides, b: ControlOverrides) -> bool:
objects are equal.
Two `ControlOverrides` objects are equal if they contain the same
:class:`BooleanSpace<balm.types.BooleanSpace>` objects, without respect to
order.
:class:`BooleanSpace<balm.types.BooleanSpace>` objects, regardless of their
ordering.
Parameters
----------
Expand Down
9 changes: 8 additions & 1 deletion balm/drivers.py
Original file line number Diff line number Diff line change
@@ -1,3 +1,7 @@
"""
A module which provides functions for processing the stable motif driver nodes of a Boolean network.
"""

from __future__ import annotations

from biodivine_aeon import AsynchronousGraph, BooleanNetwork
Expand Down Expand Up @@ -40,7 +44,10 @@ def find_single_node_LDOIs(
Example
_______
>>> import balm
>>> sd = balm.SuccessionDiagram.from_rules('A, A\\nB, A')
>>> sd = balm.SuccessionDiagram.from_rules(\"\"\"
>>> A, A
>>> B, A
>>> \"\"\")
>>> ldois = balm.drivers.find_single_node_LDOIs(sd.network)
>>> for k in sorted(ldois):
... print(f'{k} ==> {sorted(ldois[k].items())}')
Expand Down
12 changes: 9 additions & 3 deletions balm/interaction_graph_utils.py
Original file line number Diff line number Diff line change
@@ -1,3 +1,8 @@
"""
A utility module which provides several methods for manipulating the influence graph
of a Boolean network.
"""

from __future__ import annotations

from typing import TYPE_CHECKING, Literal
Expand Down Expand Up @@ -79,7 +84,8 @@ def feedback_vertex_set(
Must be `"positive"`, `"negative"`, or `None` (default). If
`"positive"`, only cycles with an even number of negative edges are
considered. If `"negative"`, only cycles with an odd number of negative
edges are considered. Otherwise, all cycles are considered.
edges are considered. Edges with no monotonicity are counted as both
positive and negative. Otherwise, all cycles are considered.
subgraph : Sequence[str | VariableId] | None, optional
A list of network variables (either string names or AEON `VariableId`
objects are fine). If given, the result is the FVS of the sub-graph induced by
Expand Down Expand Up @@ -118,8 +124,8 @@ def feedback_vertex_set(
def cleanup_network(network: BooleanNetwork) -> BooleanNetwork:
"""
Prepare a `BooleanNetwork` object for use in a `SuccessionDiagram`. This
mainly and fixes any static constraints to ensure that they are actually
correct.
mainly ensures that the network does not use parameters and fixes all static
constraints to ensure that they are actually correct.
Parameters
----------
Expand Down
56 changes: 33 additions & 23 deletions balm/motif_avoidant.py
Original file line number Diff line number Diff line change
@@ -1,5 +1,6 @@
"""
A module responsible for detecting motif-avoidant attractors within terminal restriction space.
A module which provides utility methods for detecting motif-avoidant attractors
within a terminal restriction space.
"""

from __future__ import annotations
Expand Down Expand Up @@ -32,25 +33,32 @@ def make_retained_set(
child_spaces: list[BooleanSpace] | None = None,
) -> BooleanSpace:
"""
Calculate the retained set.
Calculate the retained set for a given `space`.
The retained set is technically a space-like object that describes the
variables which have to be fixed in order for the network to lose all
complex attractors. However, note that this really means changing the update
functions. I.e. this is not a trap space that only contains fixed-points,
but a description of how the network must be modified to eliminate complex
attractors.
functions. This is not a trap space that only contains fixed-points,
but a description of how the network must be modified to eliminate
all complex attractors in the given `space`.
Finally, the construction guarantees that any complex attractor of the old
network will manifest as at least one fixed-point in the new network.
The construction guarantees that any complex attractor of the old
network will manifest as at least one fixed-point in the new network. But this
network modification is not implemented here. This method only generates
the necessary list of variables and values.
Finally, note that the method uses a heuristic to select values
that should lead to the least amount of fixed-points in
the modified network.
Parameters
----------
graph : AsynchronousGraph
The symbolic update functions stored as an `AsynchronousGraph` object
from the `biodivine_aeon` library.
nfvs : list[str]
The list of fixed variables in the current NFVS.
The list of variables in the NFVS that is valid for a network
restricted to the given `space`.
space : BooleanSpace
A :class:`BooleanSpace<balm.types.BooleanSpace>` object describing the
current trap space.
Expand Down Expand Up @@ -122,20 +130,22 @@ def detect_motif_avoidant_attractors(
is_in_an_mts: bool = False,
) -> list[BooleanSpace]:
"""
Determine which candidate seed states correspond to motif-avoidant attractors.
Compute a sub-list of `candidates` which correspond to motif-avoidant
attractors. Other method inputs:
Determine which seed states from the `candidates` list map to true
motif-avoidant attractors.
`graph` and `petri_net` represent the model in which the property
should be checked.
Assumes that all attractors in the `terminal_restriction_space` are
covered by at least one state in `candidates`. Eliminates all states
from `candidates` that are provably not in an attractor, or that correspond
to an attractor that is already covered by some other candidate.
`terminal_restriction_space` is a symbolic set of states which contains
all motif avoidant attractors (i.e. if a candidate state can leave this
set, the candidate cannot be an attractor).
The method consists of two steps: initial pruning, and exact reachability
analysis. As such, the result is always complete. However, some of the
parameters can be used to adjust the initial pruning step.
`max_iterations` specifies how much time should be spent on the simpler
preprocessing before applying a more complete method.
If `is_in_an_mts` is set, the method assumes the `candidates` are members
of a minimal trap space. In such case, a different simulation algorithm
is used for initial pruning. Furthermore, `max_iterations` can be used to
to limit the time spent on the initial pruning step.
Parameters
----------
Expand All @@ -149,14 +159,14 @@ def detect_motif_avoidant_attractors(
describing the candidate seed states.
terminal_restriction_space : Bdd
A symbolic set of states which contains all motif avoidant attractors
(i.e. if a candidate state can leave this set, the candidate cannot be
an attractor).
in question (i.e. if a candidate state can leave this set, the candidate
cannot be an attractor).
max_iterations : int
Specifies how much time should be spent on the simpler preprocessing methods.
is_in_an_mts : bool, optional
By default `False`. If `True`, the the we assume that the candidates lie
By default `False`. If `True`, then we assume that the candidates lie
within a minimal trap space, enabling certain optimizations. If
incorrectly set to `True`, correct behaviour is not guaranteed.
incorrectly set to `True`, the result is undefined.
Returns
-------
Expand Down
10 changes: 5 additions & 5 deletions balm/petri_net_translation.py
Original file line number Diff line number Diff line change
Expand Up @@ -116,7 +116,7 @@ def variable_to_place(variable: str, positive: bool) -> str:

def place_to_variable(place: str) -> tuple[str, bool]:
"""
Extract the variable name and state from a Peteri net place name.
Extract the variable name and state from a Petri net place name.
Parameters
----------
Expand Down Expand Up @@ -200,9 +200,9 @@ def restrict_petrinet_to_subspace(
Creates a copy of the given Petri net, but with the variables given in
`sub_space` fixed to their respective values.
Note that this completely eliminates the constant variables from the {etri
Note that this completely eliminates the constant variables from the Petri
net, but it does not perform any further constant propagation or
percolation. Variables that are fixed in the sub_space but do not exist in
percolation. Variables that are fixed in the `sub_space` but do not exist in
the Petri net are ignored.
Parameters
Expand Down Expand Up @@ -261,7 +261,7 @@ def network_to_petrinet(
"""
Convert a Boolean network to a Petri net.
Converts a `BooleanNetwork` to a `DiGraph` representing a Petri net encoding
Converts a `biodivine_aeon.BooleanNetwork` to a `DiGraph` representing a Petri net encoding
of the original network. For details about the encoding, see module
description.
Expand All @@ -270,7 +270,7 @@ def network_to_petrinet(
The operation uses translation through `biodivine_aeon.Bdd` to generate a
disjunctive normal form of the network's update functions. This is
facilitated by `biodivine_aeon.SymbolicContext`. If such context already
facilitated by `biodivine_aeon.SymbolicContext`. If a suitable context already
exists, it can be provided as the second argument. Otherwise it will be
created.
Expand Down
36 changes: 21 additions & 15 deletions balm/space_utils.py
Original file line number Diff line number Diff line change
Expand Up @@ -2,7 +2,8 @@
Some basic utility operations on spaces (partial assignments of BN variables).
Each space is represented as a dictionary with a subset of variable names as
keys and values `0`/`1` assigned to fixed variables.
keys and values `0`/`1` assigned to fixed variables. See also
:class:`BooleanSpace<balm.types.BooleanSpace>`.
"""

from __future__ import annotations
Expand Down Expand Up @@ -85,6 +86,9 @@ def dnf_function_is_true(dnf: list[BooleanSpace], state: BooleanSpace) -> bool:
"""
Checks if a DNF function evaluates to `1` for the given state (or space).
The DNF function is represented as a list of spaces, such that each space represents
exactly one DNF clause.
Parameters
----------
dnf : list[BooleanSpace]
Expand All @@ -110,9 +114,9 @@ def remove_state_from_dnf(
dnf: list[BooleanSpace], state: BooleanSpace
) -> list[BooleanSpace]:
"""
Removes all conjunctions that are True in the state.
Removes all clauses (conjunctions) that are `True` in the given `state` from a DNF function.
Returns a modified copy (i.e., it does not modify the original list).
The result is a new list (i.e., it does not modify the original list).
Parameters
----------
Expand Down Expand Up @@ -203,7 +207,7 @@ def percolate_space(
Percolates a space through a Boolean network.
Takes a symbolic `AsynchronousGraph` and a `BooleanSpace`. It then percolates
any values that are effectively constant with the `network` assuming the variables
any values that are effectively constant within the `network` assuming the variables
from `space` are fixed accordingly.
If the argument is a trap space, then the result is a subspace of the
Expand Down Expand Up @@ -377,11 +381,12 @@ def restrict_expression(
The space to restrict to.
symbolic_context : BddVariableSet | SymbolicContext | None
An optional symbolic context to use to perform the percolation. If not given,
a temporary one will be created. If given, it can be either a
`biodivine_aeon.SymbolicContext` or a `biodivine_aeon.BddVariableSet`.
If the former is given, it is converted to the latter. The context is
used to ensure compatibility between BDDs by ensuring that the same
variable names and ordering are used.
a temporary one will be created.
This is a `biodivine_aeon.BddVariableSet` or a `biodivine_aeon.SymbolicContext`
(which is automatically converted to `biodivine_aeon.BddVariableSet`).
The context object ensures compatibility between BDDs by
maintaining a shared collection of variable names and their ordering.
Returns
-------
Expand Down Expand Up @@ -410,7 +415,7 @@ def expression_to_space_list(
symbolic_context: BddVariableSet | SymbolicContext | None = None,
) -> list[BooleanSpace]:
"""
Convert a Boolean expression to a list of subspaces on which it is true.
Convert a Boolean expression to a list of subspaces for which it is true.
Equivalent to a disjunctive normal form. Convert a `BooleanExpression` to a
list of subspaces whose union represents an equivalent set of the network
Expand All @@ -429,11 +434,12 @@ def expression_to_space_list(
The expression to convert.
symbolic_context : BddVariableSet | SymbolicContext | None
An optional symbolic context to use to perform the percolation. If not given,
a temporary one will be created. If given, it can be either a
`biodivine_aeon.SymbolicContext` or a `biodivine_aeon.BddVariableSet`.
If the former is given, it is converted to the latter. The context is
used to ensure compatibility between BDDs by ensuring that the same
variable names and ordering are used.
a temporary one will be created.
This is a `biodivine_aeon.BddVariableSet` or a `biodivine_aeon.SymbolicContext`
(which is automatically converted to `biodivine_aeon.BddVariableSet`).
The context object ensures compatibility between BDDs by
maintaining a shared collection of variable names and their ordering.
Returns
-------
Expand Down
10 changes: 5 additions & 5 deletions balm/succession_diagram.py
Original file line number Diff line number Diff line change
Expand Up @@ -76,7 +76,7 @@ class SuccessionDiagram:
threshold, we find a feedback vertex set (without consideration of cycle
sign) for reachability preprocessing. There is a trade-off between the speed
gains from a smaller node set to consider and the cost of determining which
FVS nodes only intersect negative cycles to find an NFVS subset. Typcially,
FVS nodes only intersect negative cycles to find an NFVS subset. Typically,
for smaller networks, the trade-off is in favor of computing a smaller NFVS.
"""

Expand All @@ -103,7 +103,7 @@ def __init__(self, network: BooleanNetwork):

self.petri_net: nx.DiGraph = network_to_petrinet(network)
"""
The Petri net representation of the network.
The Petri net representation of the network (see :mod:`petri_net_translation<balm.petri_net_translation>`).
"""

if DEBUG:
Expand Down Expand Up @@ -306,7 +306,7 @@ def node_ids(self) -> Iterator[int]:

def stub_ids(self) -> Iterator[int]:
"""
Iterator over all node IDs that are currently not expanded.
Iterator over all node IDs that are currently *not* expanded.
"""
for i in range(len(self)):
if not self.node_data(i)["expanded"]:
Expand Down Expand Up @@ -430,8 +430,8 @@ def node_data(self, node_id: int) -> NodeData:
Returns a `NodeData` object with the following attributes:
- `depth`: The depth of the node.
- `attractors`: The attractors of the node.
- `petri_net`: The Petri net representation of the node.
- `attractors`: The attractors of the node (if computed).
- `petri_net`: The Petri net representation of the node (if computed).
- `space`: The sub-space of the node.
- `expanded`: Whether the node is expanded or not.
Expand Down
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