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# CRAN Comments | ||
# CRAN Comments for nlmixr2est 3.0.1 | ||
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- Bug fixes and version to support new rxode2 without binary linkage | ||
to it (only api not abi) | ||
## New features | ||
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- Now when optimizing only a single parameter with `focei`-family, | ||
will change to use `stats::optimize()` for the outer problem (#481) | ||
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- When estimating with all fixed population parameters, do a posthoc | ||
estimation. | ||
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- Internally removed `assignInMyNamespace()` replacing with | ||
`nlmixr2global`, which fixes some edge case bugs where the nlmixr2 | ||
environment was not reset properly. | ||
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- Treated edge case where all initial parameters are zero and change | ||
scaling from scaled to unscaled (#486) | ||
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- Added `mu`4 referencing that will change string expressions to | ||
`rxode2` numeric values. This allows derived strings to also be | ||
treated as `mu` expressions (#484) | ||
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## Bug Fixes | ||
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- Fix `focei` covariance step when many `omega` values are fixed #482 |