v2.2.0

New Features

• Algebraic mu referencing has been implemented in nlme and saem.

• New estimation method "nlm" has been added to estimate population
  only likelihoods using stats::nlm and possibly return a
  standardized nlmixr2 fit.

• New estimation method "nls" has been added to estimate population
  only problems. This uses minpack.lm::nlsNM by default if
  present, or the stats::nls

• New estimation method "optim" has been added to estimate population
  only likelihoods. This uses stats::optim and returns a
  standardized nlmixr2 fit.

• New estimation method "nlminb" has been added to estimate population
  only likelihoods. This uses stats::nlminb and returns a
  standardized nlmixr2 fit.

• New estimation methods from the minqa package: "bobyqa", "uobyqa"
  and "newuoa" have been added to estimate population only
  likelihoods. These methods returns a standardized nlmixr2 fit.

• New estimation method "lbfgsb3c" to estimate population only
  likelihoods. This returns a standardized nlmixr2 fit.

• New estimation method "n1qn1" to estimate population only
  likelihoods. This returns a standardized nlmixr2 fit.

• Added new feature for vpcSim() where a minimum number of subjects
  are simulated from the model when trying to fill in ODEs that were
  not solved successfully. By default this is 10. This also
  works-around a bug when there is only one subject simulated and the
  data.frame has a slightly different output.

Breaking changes

• Removed fit$saemTransformedData since it isn't actually used in
  saem anymore (but will break anyone's code who is using it)

• Now the internal function .foceiPreProcessData() requires the
  rxode2 control rxControl() because some of the new steady state
  lag features need to translate the data differently based on
  rxControl() options.

Bug fixes

• Printing models with correlated omega values and omega values fixed
  to zero no longer fails (#359)

• Add back values for $parHistData (#368)

• This requires a new rxode2 which will fix multiple endpoint issues observed (#394)

• Manual back-transformed values in $parFixed are now displaying
  correctly and are calculated based on the confidence interval in the
  control instead of 95% confidence no matter what (#397)

Other changes

• An as.rxUi() method was added for fit models (#377)

What's Changed

• Add mu2 processing by @mattfidler in #354
• Fix #359 by @billdenney in #360
• Return fit without table if table step fails by @mattfidler in #364
• Fix 366 by @billdenney in #367
• Only keep $parHistData and calc $parHist and $parHistStacked by @mattfidler in #370
• Clarify keep argument to vpcSim() by @billdenney in #380
• Quieter compile by @billdenney in #381
• 376 make sure and test that fit$eta are non zero by @mattfidler in #383
• With a zero gradient always reset by @mattfidler in #384
• 387 sslag ettrans rxcontrol update by @mattfidler in #388
• 394 error drugmetabolite modeing after zero oder absorption by @mattfidler in #395
• V2.1.7 by @mattfidler in #396
• Fix for #397, needs test still by @mattfidler in #398
• add as.rxUi() method for fit objects by @billdenney in #378
• V2.1.8 by @mattfidler in #401
• 402 nlm by @mattfidler in #403
• 404 nls by @mattfidler in #405
• 406 optim by @mattfidler in #407
• Fix lbfgsb3c documentation by @mattfidler in #408
• Udf by @mattfidler in #409
• 411 cran requests by @mattfidler in #413

Full Changelog: v2.1.8...v2.2.0