In this study, we investigated the mechanisms of focal oncogene amplifications by analyzing the pattern of structural variations (SVs) at the boundary of amplicons. Step-by-step analysis procedures are described in Workflow, and the associated scripts and small data files are deposited in this page.
The somatic variants of 780 breast cancer cases are available through the Park Lab Website.
Related publication: Lee JJ et al. ERɑ-associated translocations underlie oncogene amplifications in breast cancer. Nature (2023) doi:/10.1038/s41586-023-06057-w