DallphinAtoM v0.9.9.5

Official release site:
http://pipet.or.kr/board/apps_view.asp?curPage=1&keyword=&idx=1050

DallphinAtoM v0.9.9

Release Notes

1. Bug fixes: fixed several issues where calculation was inaccurate

• Official release site:
  http://pipet.or.kr/board/apps_view.asp?curPage=1&keyword=&idx=1050

DallphinAtoM v0.9.8.5

Release Notes

1. Minor changes (default uncheck status and order of data input) in the Basic Info tab were given to avoid confusion.

• Official release site:
  http://pipet.or.kr/board/apps_view.asp?curPage=1&keyword=&idx=1050

DallphinAtoM v0.9.8

Release Notes

1. The error in the PBPK method section in the Distribution tab was corrected.

• Official release site:
  http://pipet.or.kr/board/apps_view.asp?curPage=1&keyword=&idx=1050

DallphinAtoM v0.9.7

Release Notes

1. The calculation and simulation speed has been improved.
2. In NCA tab, the digit of numbers is fixed.
3. Minor bugs are corrected.

• Official release site:
  http://pipet.or.kr/board/apps_view.asp?curPage=1&keyword=&idx=1050

DallphinAtoM v0.9.6

Release Notes

1. Noncompartmental analysis is possible (NCA tab).
2. In distribution tab, more Kp calculation methods can be selected.
3. A save/load feature is available using a Microsoft Excel file (xlsx).

• Official release site:
  http://pipet.or.kr/board/apps_view.asp?curPage=1&keyword=&idx=1050

DallphinAtoM v0.9.5

Release Notes

1. In Elimination tab, previously, Hepatic CL of CLh (Method2) based on microsome assay was calculated only with Rat data, now Dog and Monkey data can be used.
2. In Basic info tab, a field to receive the fu_monkey value required for calculation was added.
3. In Elimination tab, the fu_mic and fu_hep values were not properly reflected in the CLh and Fh result values.

• Official release site:
  http://pipet.or.kr/board/apps_view.asp?curPage=1&keyword=&idx=1050

DallphinAtoM v0.9.4

Release Notes

1. Erroneous simulation of i.v. infusion was corrected in the “Conc. Prediction” tab.
2. The unit of Vdss in the “Conc. Prediction” tab was corrected.
3. Both Fa(Caco) and Fa(Caco, ki) are presented in the “Final Parameters” tab.

• Official release site:
  http://pipet.or.kr/board/apps_view.asp?curPage=1&keyword=&idx=1050

DAllPhin-AtoM v0.9.3

Release Notes

1. Notes were added for the details of the parameters.
2. Conc. Prediction Tab: The values of the AUC of a single dosing (AUC_{single dose,tau}) over dosing interval, AUC of steady state over dosing interval (AUC_ss,tau), peak concentration at steady state (Cmax,ss) were added.
3. ‘CLother’ was added in the Elimination tab to allow users to input intrinsic hepatic CL values according to their prior knowledge or information.
4. Some parameter names were changed for clarification. (Check the abbreviation section in manual!)
5. Hepatocyte surface area calculation method used to predict passive diffusion CL was fixed.

• Official release site:
  http://pipet.or.kr/board/apps_view.asp?curPage=1&keyword=&idx=1050

DAllPhin-AtoM v0.9.2

Release Notes

1. Erroneous simulation due to inconsistent units of final parameters was fixed.

• Official release site:
  http://pipet.or.kr/board/apps_view.asp?curPage=1&keyword=&idx=1050