pareto-optimality endoplasmic-reticulum crowd-analysis integer-linear-programming anomalous-events mitotic-inhibitors actin-tropomyosin tubulin-kinesin ibm-ilog-cplex-optimizer monastrol s-trityl-l-cysteine blebbistatin neuronal-axon-growth-cone accident-aversion-system max-flow-min-cost kinesin-like-protein-kif11 dynein-inhibitor shortest-path-and-graph-pruning nuclear-pore multipolar-spindles