A new perspective for mitigation of SARS-CoV-2 infection: priming the innate immune system for viral attack

Oren Kolodny, Michael Berger, Marcus W. Feldman, and Yoav Ram

Open Biology 2020

This repository contains a Jupyter notebook used to produce the Figure in the paper. The notebook contains the model implementation.

The following equation system describes the model:

with these variables and parameters (all rates are in 1/day):

• S: susceptible
• E: exposed
• I1: infected without priming
• I2: infected with priming
• H: hospitalized
• R: recovered
• N: total population size (constant)
• β (beta): transmission rate
• δ (delta): incubation rate
• α (alpha): fraction of population receiving priming
• r: clearance rate infected
• ρ (rho): increase in clearance rate due to priming
• h: hospitalization rate of infected
• γ (gamma): clearance rate of hospitalized

License

CC-BY-SA 4.0